A5027160995- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Child Nutrition and Feeding Issues
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Adolescent and Pediatric Healthcare
- Immunodeficiency and Autoimmune Disorders
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Autoimmune and Inflammatory Disorders Research
- Obesity, Physical Activity, Diet
- Celiac Disease Research and Management
- Childhood Cancer Survivors' Quality of Life
- Family and Disability Support Research
- Intestinal and Peritoneal Adhesions
- Pharmaceutical studies and practices
- Esophageal and GI Pathology
- Infant Nutrition and Health
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Foreign Body Medical Cases
- Child Nutrition and Water Access
- Gastrointestinal motility and disorders
- Microbial Metabolites in Food Biotechnology
Emma Kinderziekenhuis
2015-2024
University of Amsterdam
2013-2024
Amsterdam University Medical Centers
2019-2024
Amsterdam UMC Location University of Amsterdam
2007-2019
Vrije Universiteit Amsterdam
2019
Fundación Juan March
2017
Erasmus MC - Sophia Children’s Hospital
2017
Keio University
2014
Boston Children's Hospital
2013
Wroclaw Medical University
2013
Serious and fatal complications after button battery ingestion are increasing worldwide. The aim of this study is to describe serious in children the Netherlands.All pediatric gastroenterologists Netherlands performing upper endoscopies were asked report all (0-18 years) between 2008 2016 retrospectively.Sixteen reported: death massive bleeding through esophageal-aortal fistula (n = 1), esophageal-tracheal 5), stenosis (suspected) perforation mediastinitis 3), vocal cord paralysis required...
Abstract A nutritional intervention, exclusive enteral nutrition (EEN) can induce remission in patients with pediatric Crohn’s disease (CD). We characterized changes the fecal microbiota and metabolome to identify mechanism of EEN. Feces 43 children were collected prior, during after Microbiota metabolites analyzed by 16S rRNA gene amplicon sequencing NMR. Selected evaluated relevant model systems. CD controls different at all time points. Amino acids, primary bile salts, trimethylamine...
For the choice of treatment in children with inflammatory bowel disease (IBD), it is important to make a distinction between Crohn (CD) and ulcerative colitis (UC). To look for pathognomonic features CD, upper gastrointestinal tract (UGT) endoscopy has become part routine evaluation suspected IBD; however, pathological changes can also be found UGT patients UC. The aims present study were establish role involvement diagnostic assessment IBD detect histopathological mucosa, which distinguish...
The 13C-urea breath test for diagnosis of Helicobacter pylori infection has not been validated in infants and young children. influence age on the results was studied by conventional validation against invasive methods mathematical estimation a large pediatric population.The performed 1499 children aged 2 months to 18 years. After fasting period 4 hours or more, 75 mg ingested with cold apple juice, samples were taken at baseline 15 30 minutes. distribution natural logarithms delta-over...
Infliximab is effective for induction and maintenance of remission in children with moderately to severely active Crohn's disease (CD).To evaluate the long-term efficacy infliximab treatment paediatric CD.In this observational, multicentre study, all CD patients The Netherlands treated from October 1992 November 2009 minimal follow-up 3 months since start infliximab, were studied.One hundred fifty-two [81M; median age at 15.0 years (IQR 13.1-16.4)] received a number 10.5 infusions 6-21)....
Conventional follow-up of teenagers with inflammatory bowel diseases [IBD] is done during scheduled outpatient visits regardless how well the patient feels. We designed a telemonitoring strategy for early recognition flares and compared its efficacy conventional follow-up.We used multicentre randomized trial in patients aged 10-19 years IBD clinical remission at baseline. Participants assigned to received automated alerts complete symptom score send stool sample measurement calprotectin....
Pathological food refusal (PFR) is not rare in young children with chronic conditions requiring prolonged tube feeding. We investigated whether these could be weaned from feeding a multidisciplinary hunger provocation program.The study included younger than 2 years PFR who had been dependent on for at least 3 months. They followed in-hospital program. During step 1, only 50% of the normal allowance was given by tube. 2, oral offered and completed up to afterwards. 3, supplementary night. 4,...
Journal Article Use of exclusive enteral nutrition in paediatric Crohn's disease The Netherlands Get access Charlotte de Bie, Bie aDepartment Paediatric Gastroenterology, Erasmus MC—Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ, Rotterdam, Search for other works by this author on: Oxford Academic PubMed Google Scholar Angelika Kindermann, Kindermann bDepartment Medical Centre—Emma Meibergdreef 9, 1100 DD, Amsterdam, Johanna Escher ⁎Corresponding author. Tel.: + 31 10 7036076;...
Children with congenital malformations, mental retardation, and complex early medical history frequently have feeding problems. Although tube is effective in providing the necessary energy nutrients, it decreases child's motivation to eat may lead oral aversion. In this study, we sought confirm our previous results, showing that a multidisciplinary clinical hunger provocation program quick resumption of feeding.In crossover 22 children 9 24 months age who were fully dependent on randomly...
Low serum trough levels (TLs) of infliximab (IFX) and antibodies to IFX (ATIs) are associated with the loss therapeutic response in adults inflammatory bowel disease (IBD) receiving IFX. Until now, pediatric data scarce. Therefore, we aimed cross-sectionally investigate association between ATIs TLs, clinical biochemical activity children for IBD.Children aged <18 years maintenance treatment Crohn's (CD) or ulcerative colitis (UC) at three Dutch hospitals were included. Prior two consecutive...
Summary Background A large proportion (25–46%) of adults with inflammatory bowel disease in remission has symptoms irritable syndrome ( IBS ), which are thought to reflect ongoing inflammation. Data on paediatric patients lacking. Aim To investigate (i) the prevalence ‐type and (ii) relationship biochemical markers activity. Methods This cross‐sectional study included all (<18 years) Crohn's or ulcerative colitis attending out‐patient clinic one three Dutch hospitals between March 2014...
Abstract Objective The aim of this study was to compare health related quality life (HRQOL) in infants and children with avoidant restrictive food intake disorder (ARFID) healthy chronically ill controls. Method A cross‐sectional conducted who meet ARFID criteria at our tertiary care pediatric feeding clinic (September 2014 July 2016). Before consultation, parents patients ( n = 100) were asked complete questionnaires determine HRQOL: the TNO‐AZL Preschool Children Quality Life (0–5 years),...
The interrelation between the course of inflammatory bowel disease (IBD) in children and parent's distress, subsequent impact this may have on health-related quality life (HRQOL) child is unclear. Therefore, we investigated patient's HRQOL parental distress association IBD, pediatric patients with IBD.Pediatric IBD (8-18 years) parents were invited. Patients completed Pediatric Quality Life Inventory, Distress Thermometer for Parents, simultaneously. Disease was expressed as current clinical...
Studies on the outcome of ileocecal resection in pediatric Crohn's disease (CD) have a limited follow-up and fail to assign predictors adverse outcomes. Therefore, we aimed investigate (I) complication recurrence rates (II) identify risk factors for these outcomes after CD. This is retrospective cohort analysis all children (<18 years) that underwent as first intestinal CD derived from 7 tertiary hospitals Netherlands (1990–2015). Risk were identified using multivariable analysis. In total,...
The goal of first-line Helicobacter pylori therapy is to reach an eradication rate 90% avoid further investigations, antibiotic use, and spreading resistant strains.To evaluate the high-dose sequential in treatment-naïve children assess factors associated with failure.Prospective data assessed a registry from nine European centers between October 2009 December 2011. Children biopsy-proven infection were prescribed 5 days esomeprazole amoxicillin, followed by esomeprazole, clarithromycin,...
In specialist care, fecal calprotectin (FCal) is a commonly used noninvasive diagnostic test for ruling out inflammatory bowel disease (IBD) in children with chronic gastrointestinal symptoms. The aim of this study was to evaluate the accuracy FCal IBD symptomatic primary care.We studied 2 prospective cohorts diarrhea, recurrent abdominal pain, or both: initially seen care (primary cohort) and referred (referred cohort). (index test) measured at baseline compared 1 reference standards IBD:...
Objectives: Currently, there is no consensus on how to score Crohn disease (CD) activity assessed by intestinal ultrasound (IUS) in children. This study aimed design an easy-to-use IUS for pediatric CD. Methods: Children undergoing ileo-colonoscopy CD assessment underwent the day before ileo-colonoscopy, with simple endoscopic (SES-CD). features were compared SES-CD segmental level. Multiple regression analyses, separately terminal ileum (TI) and colon, done assess predictors of develop a...