A5002720106- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Pharmaceutical studies and practices
- Gastrointestinal motility and disorders
- Helicobacter pylori-related gastroenterology studies
- Health Systems, Economic Evaluations, Quality of Life
- Neonatal Respiratory Health Research
- Pediatric Pain Management Techniques
- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Immune responses and vaccinations
- Parasitic Infections and Diagnostics
- Parasites and Host Interactions
- Colorectal Cancer Screening and Detection
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Pediatric Hepatobiliary Diseases and Treatments
- Amoebic Infections and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Appendicitis Diagnosis and Management
- Gallbladder and Bile Duct Disorders
- Childhood Cancer Survivors' Quality of Life
- Asthma and respiratory diseases
- Infant Health and Development
University Medical Center Groningen
2015-2023
General Department of Preventive Medicine
2020
University of Groningen
2015-2019
Emma Kinderziekenhuis
2014
Background & AimsAn increasing number of physicians use repeated measurements stool calprotectin to monitor intestinal inflammation in patients with inflammatory bowel diseases (IBDs). A lateral flow-based rapid test allows measure their own values at home. The comes a software application (IBDoc; Bühlmann Laboratories AG, Schönenbuch, Switzerland) that turns smartphone camera into results reader. We compared from this method those the hospital-based reader (Quantum Blue; AG) and...
Conventional follow-up of teenagers with inflammatory bowel diseases [IBD] is done during scheduled outpatient visits regardless how well the patient feels. We designed a telemonitoring strategy for early recognition flares and compared its efficacy conventional follow-up.We used multicentre randomized trial in patients aged 10-19 years IBD clinical remission at baseline. Participants assigned to received automated alerts complete symptom score send stool sample measurement calprotectin....
To study the association between
Background: We designed a telemonitoring strategy for teenagers with inflammatory bowel disease to prevent an anticipated flare and avert unplanned office visits day care procedures. The was evaluated in randomized controlled trial that involved 11 Dutch pediatric gastroenterology centers, each using repeated symptom scores stool calprotectin measurements. In the arm of trial, (n=84) as well their health providers were alerted out-of-range results, suggestions change therapy offered....
To prevent clinical relapse in teenagers with inflammatory bowel disease (IBD) there is a need to monitor activity continuously. Timely optimisation of medical treatment may nip preclinical the bud and change natural course IBD. Traditionally, monitoring done during scheduled visits, but this when most report full control. IBD care could be more efficient if patients were seen at times need. This study aims examine effectiveness web-assisted calprotectin-based algorithm (IBD-live) compared...
Objective Calgranulin-C (S100A12) is a new faecal marker of inflammation that potentially more specific for inflammatory bowel disease (IBD) than calprotectin, since it only released by activated granulocytes. We compared calgranulin-C and calprotectin to see which the two tests best predicted IBD in children with chronic abdominal pain diarrhoea. Design Delayed-type cross-sectional diagnostic study. Setting patients Previously undiagnosed aged 6–17 years, who were seen paediatric clinics...
In children with suspected inflammatory bowel disease, adding calprotectin stool testing to the screening strategy has been recommended distinguish organic from nonorganic disease. this cohort study historical controls, we could not confirm that improves diagnostic yield (ratio disease-positive endoscopies and total number of endoscopies); however, in patients normal fecal levels (<50 μg/g) endoscopic histological abnormalities were seen. We propose refrain endoscopy when are normal.
Introduction The introduction of the faecal calprotectin (FC) test to screen children with chronic gastrointestinal complaints has helped clinician decide whether or not subject patient endoscopy. In spite this, a considerable number patients without inflammatory bowel disease (IBD) is still scoped. Faecal calgranulin C (S100A12) marker intestinal inflammation that potentially more specific for IBD than FC, as it exclusively released by activated granulocytes. Objective To determine...
We evaluated 4 diagnostic strategies to predict the presence of inflammatory bowel disease (IBD) in children who present with chronic nonbloody diarrhea and abdominal pain.We conducted a prospective cohort study including 193 patients aged 6 18 years underwent standardized workup secondary or tertiary care hospitals. Each patient was assessed for symptoms, C-reactive protein (>10 mg/L), hemoglobin (<-2 SD age sex), fecal calprotectin (≥250 μg/g). Patients rectal bleeding perianal were...
Introduction Children often present to primary care with functional abdominal pain (FAP) or irritable bowel syndrome (IBS), and around half still have complaints 1 year later. Hypnotherapy is an evidence-based treatment that used in specialist care, but it lacks evidence care. This study will investigate the (cost) effectiveness of home-based guided hypnotherapy for children FAP IBS Methods analysis We report design a pragmatic randomised controlled trial among aged 7–17 years, diagnosed by...
Abstract Background: Calgranulin C (S100A12) is an emerging marker of inflammation. It exclusively released by activated neutrophils which makes this potentially more specific for inflammatory bowel disease (IBD) compared to established stool markers including calprotectin and lactoferrin. We aimed establish a reference value S100A12 in healthy children investigated whether levels can discriminate with IBD from controls. Methods: In prospective community-based interval study we collected 122...
Background: For 8 years we have been following patients with inflammatory bowel disease by periodically measuring calprotectin levels in their sent-in stool samples an enzyme-linked immunosorbent assay (ELISA). Levels below 250 μg/g confirmed remission, above 500 indicated a flare, and indecisive values between required retesting after 1 month. Physicians found repeated testing of helpful to guide therapy, but both wished receive the results without delay. BÜHLMANN Laboratories recently...
<sec> <title>BACKGROUND</title> We designed a telemonitoring strategy for teenagers with inflammatory bowel disease to prevent an anticipated flare and avert unplanned office visits day care procedures. The was evaluated in randomized controlled trial that involved 11 Dutch pediatric gastroenterology centers, each using repeated symptom scores stool calprotectin measurements. In the arm of trial, (n=84) as well their health providers were alerted out-of-range results, suggestions change...