A5085115626- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Cell Adhesion Molecules Research
- S100 Proteins and Annexins
- Vasculitis and related conditions
- Inflammatory Bowel Disease
- Orthopedic Infections and Treatments
- Hormonal Regulation and Hypertension
- Health Systems, Economic Evaluations, Quality of Life
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Sepsis Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Pituitary Gland Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cutaneous Melanoma Detection and Management
- Growth Hormone and Insulin-like Growth Factors
- Neonatal Respiratory Health Research
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Electrolyte and hormonal disorders
- Vitamin D Research Studies
- Gestational Diabetes Research and Management
- Total Knee Arthroplasty Outcomes
- Thyroid and Parathyroid Surgery
University of Groningen
2016-2025
University Medical Center Groningen
2016-2025
Rijksmuseum
2020
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2017
Research Network (United States)
2017
RELX Group (United States)
2017
Boston University
2016
Weatherford College
2010
Isala
2010
Abstract. de Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, Gilst WH, Hillege HL, Bakker SJL, der Harst P (University of Groningen). The fibrosis marker galectin‐3 and outcome in the general population. J Intern Med 2012; 272 : 55–64. Objective. Galectin‐3 is involved inflammation plays a role heart failure, renal disease, obesity cancer. We aimed to establish relationship between cardiovascular (CV) risk factors mortality Design subjects. This study included 7968 subjects from...
The clustering of metabolic and cardiovascular risk factors is known as syndrome (MetS). having MetS strongly associated with increased adiposity can be further modified by smoking behavior. Apolipoproteins (apo) low-density lipoprotein-cholesterol (LDL-C) high-density (HDL-C) may altered in MetS. This study aimed to examine the association between following parameters: its components, levels apolipoproteins estimated lipoprotein particle size, separately for men women, different body mass...
Biomarkers can be used for diagnosis, risk stratification, or management of patients with heart failure (HF). Knowledge about the biological variation is needed proper interpretation serial measurements. Therefore, we aimed to determine and compare a large panel biomarkers in healthy subjects chronic HF.The variability established [NT-proBNP high-sensitivity troponin T (hsTnT)], novel [galectin-3, suppression tumorigenicity 2 (ST2), growth differentiation factor 15 (GDF-15)],...
Background The prevalence of obesity, an important cardiometabolic risk factor, is rising in women. Lifestyle improvements are the first step treatment but success depends on factors like timing and motivation. Women especially receptive to advice about lifestyle before during pregnancy. Therefore, we hypothesize that pre-pregnancy period provides perfect window opportunity improve health quality life obese infertile women, by means a intervention. Methods findings Between 2009–2012, 577...
Obesity is a risk factor for SARS-CoV-2 infected patients to develop respiratory failure. Leptin produced in visceral fat might play role the deterioration mechanical ventilation. A cross sectional study was performed. The mean BMI 31 kg/m2 (range 24.8–48.4) ventilated and 26 22.4–33.5) 8 critically ill non-infected control patients. with similar as appear have significantly higher levels of serum leptin. leptin level 21.2 (6.0–85.2) vs 5.6 (2.4–8.2) ug/L controls respectively (p = 0.0007)....
Introduction: The presence of the Thr92Ala polymorphism deiodinase-2 (D2) has been thought to have several effects. It may influence its enzymatic function, is associated with increased expression genes involved in oxidative stress brain tissue, and predict favorable response combination levothyroxine (LT4) plus triiodothyronine (T3) therapy. was hypothesized that homozygous carriers D2-92Ala allele different thyroid hormone parameters, reduced health-related quality life (HRQoL) cognitive...
A model based on the soluble Fms-like tyrosine kinase-1/placental growth factor ratio, gestational age, and urinary protein-to-creatinine ratio (PRERISK calculator) has been developed to predict preeclampsia-related maternal-fetal complications. Here, we tested whether this can reduce hospital admissions without increasing complication rates among women with suspected or confirmed preeclampsia. In multicenter, open-label, randomized controlled trial conducted at 5 Dutch medical centers,...
The transition from stable to progressive disease is unpredictable in patients with biochemical evidence of medullary thyroid carcinoma (MTC). Calcitonin and carcinoembryonic antigen (CEA) doubling times are currently the most reliable markers for progression, but accurate determination, serial measurements, which need time, required. We compared <sup>18</sup>F-FDG PET <sup>18</sup>F-dihydroxyphenylanaline (<sup>18</sup>F-DOPA) parameters survival assess whether these imaging modalities...
Outcome of rhythm control in atrial fibrillation (AF) is still poor due to various mechanisms involved the initiation and perpetuation AF. Differences timing AF recurrence may depend on different types mechanisms. The aim this study was assess early patients with short-lasting Patients persistent undergoing (n= 100) were included. Markers assessed, including clinical factors, echocardiographic parameters, biomarkers. Primary endpoint (recurrence <1 month). Secondary progression permanent...
Introduction The development of metabolic syndrome (MetS) is influenced by environmental factors such as smoking and alcohol consumption. We determined the combined effects on MetS its individual components. Methods 64,046 participants aged 18–80 years from LifeLines Cohort study were categorized into three body mass index (BMI) classes (BMI<25, normal weight; BMI 25–30, overweight; BMI≥30 kg/m2, obese). was defined according to revised criteria National Cholesterol Education Program's Adult...
Background Vitamin B 12 deficiency occurs frequently, especially among the elderly. However, screening for vitamin is hampered by poor sensitivity of existing total assay. Methylmalonic acid (MMA) considered as most representative indicator metabolic and used such in this study. The aim study was to validate clinical usefulness holotranscobalamin (holoTC) an initial assay a mixed patient population. Methods Three hundred sixty blood samples were collected five Dutch hospitals. holoTC serum...
Background & AimsAn increasing number of physicians use repeated measurements stool calprotectin to monitor intestinal inflammation in patients with inflammatory bowel diseases (IBDs). A lateral flow-based rapid test allows measure their own values at home. The comes a software application (IBDoc; Bühlmann Laboratories AG, Schönenbuch, Switzerland) that turns smartphone camera into results reader. We compared from this method those the hospital-based reader (Quantum Blue; AG) and...
Vitamin D deficiency is common in renal transplant recipients (RTR). The long-term implications of vitamin RTR remain unclear. We investigated whether 25(OH) or 1,25(OH)2 levels are associated with mortality, function decline, and graft failure stable RTR. Observational study longitudinal design. Followup was 7.0, interquartile range (IQR) 6.2–7.5 years. Single-center outpatient clinic. 435 (51% men, mean age 52 ± 12 years) were included at a median [IQR] 6 [3–12] years after kidney...
Higher plasma concentrations of vitamin B12 have been associated with mortality in elderly and hospitalized populations, including patients chronic kidney disease, but the association general population remains unclear.To investigate all-cause mortality.This longitudinal cohort study used post hoc analysis to examine data from participants Prevention Renal Vascular End-stage Disease Study Groningen, Netherlands. Participants included individuals who completed second screening visit beginning...
Abstract Background Obesity is a risk factor for adverse outcomes in COVID-19, potentially driven by chronic inflammatory state due to dysregulated secretion of adipokines and cytokines. We investigated the association between plasma COVID-19 severity, systemic inflammation, clinical parameters, outcome patients. Methods In this multi-centre prospective cross-sectional study, we collected blood samples data from The severity was classified as mild (no hospital admission), severe (ward...
It is not clear why some anovulatory women with polycystic ovary syndrome (PCOS) and obesity resume ovulation others remain after weight loss. The objective of this study was to compare the changes in body fat distribution specifically intra-abdominal (IAF) subcutaneous abdominal (SAF) between a group PCOS who (RO+) those (RO−) during lifestyle program. In prospective pilot cohort study, underwent 6 month program tertiary fertility clinic. Body assessed by anthropometrics, dual-energy X-ray...
The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported relationship between thyroid function some MetS components or suggested that serum free thyroxine (FT4) triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how relates to prevalence in large population-based study....
Recently, several synovial biomarkers have been introduced into the algorithm for diagnosis of a prosthetic joint infection (PJI). Alpha defensin is promising biomarker, with high sensitivity and specificity, but it expensive. Calprotectin protein that present in cytoplasm neutrophils, released upon neutrophil activation exhibits anti-microbial activity. Our aim, this study, was to determine diagnostic potential calprotectin PJI.In pilot we prospectively collected fluid from hip, knee,...
<h3>Background</h3> Lifetime risk for cardiovascular (CV) disease is high but predicting incident events on an individual level remains difficult. Single measurements of galectin-3, a marker tissue fibrosis, predict mortality and new-onset heart failure (HF). Persistently elevated levels may indicate clinically silent process. <h3>Objectives</h3> Our aim was to establish the value serial galectin-3 CV outcomes in general population. <h3>Methods</h3> Plasma measured Prevention REnal Vascular...
Abstract Purpose The extent to which smoking is associated with thyroid stimulating hormone (TSH), free thyroxine (FT4), and triiodothyronine (FT3) when taking account of clinical variables including alcohol consumption unclear. We aimed determine associations TSH, FT4, FT3 levels current smoking. Methods A cross-sectional study was performed in 5766 euthyroid participants (Prevention Renal Vascular End-Stage Disease cohort). Current determined by self-report, categorized as never, former,...
Conventional follow-up of teenagers with inflammatory bowel diseases [IBD] is done during scheduled outpatient visits regardless how well the patient feels. We designed a telemonitoring strategy for early recognition flares and compared its efficacy conventional follow-up.We used multicentre randomized trial in patients aged 10-19 years IBD clinical remission at baseline. Participants assigned to received automated alerts complete symptom score send stool sample measurement calprotectin....