A5040615684- Thyroid Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Dialysis and Renal Disease Management
- Growth Hormone and Insulin-like Growth Factors
- Folate and B Vitamins Research
- Thyroid Cancer Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Nutrition and Health in Aging
- Iron Metabolism and Disorders
- Pharmacological Effects and Toxicity Studies
- Nutritional Studies and Diet
- Bone and Joint Diseases
- Cardiovascular and Diving-Related Complications
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Genetic Associations and Epidemiology
- Metabolism and Genetic Disorders
- Neurological and metabolic disorders
- Inflammatory Biomarkers in Disease Prognosis
- Bone health and osteoporosis research
- Pituitary Gland Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Diabetes Treatment and Management
- Blood groups and transfusion
University Medical Center Groningen
2016-2024
University of Groningen
2016-2024
Anemia is highly prevalent, especially in older individuals. In selected populations, anemia has been reported to be associated with impaired survival and health-related quality of life. However, data on this impact the general population are rare. Furthermore, discussions optimal definition have not conclusive. We investigated these issues using data, scores from a life questionnaire (RAND-36), hemoglobin concentration 138670 subjects, aged 18-93 years, participating Lifelines cohort. was...
Introduction: The presence of the Thr92Ala polymorphism deiodinase-2 (D2) has been thought to have several effects. It may influence its enzymatic function, is associated with increased expression genes involved in oxidative stress brain tissue, and predict favorable response combination levothyroxine (LT4) plus triiodothyronine (T3) therapy. was hypothesized that homozygous carriers D2-92Ala allele different thyroid hormone parameters, reduced health-related quality life (HRQoL) cognitive...
The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported relationship between thyroid function some MetS components or suggested that serum free thyroxine (FT4) triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how relates to prevalence in large population-based study....
Abstract Erythrocytosis is a common reason for referral to hematology services and usually secondary in origin. The aim of this study was assess clinical characteristics clonal hematopoiesis (CH) individuals with erythrocytosis the population-based Lifelines cohort (n = 147 167). defined using strict (World Health Organization [WHO] 2008/British Committee Standards Hematology) wide (WHO 2016) criteria. Individuals (strict criteria) concurrent leukocytosis and/or thrombocytosis were 1:2...
Background Thyroid hormone plays a pivotal role in human metabolism. In epidemiologic studies, adequate registration of thyroid disorders is warranted. We examined the prevalence disorders, reported medication use, levels, and validity data obtained from questionnaires Lifelines Cohort Study. Methods evaluated baseline all 152180 subjects (aged 18–93 years) At baseline, participants were asked about previous surgery current use. follow-up (n = 136776, after median 43 months), incident could...
Red blood cell transfusions (RBCT) remain the cornerstone of supportive care in lower-risk myelodysplastic syndrome (LRMDS) [1]. Transfusion dependency LRMDS patients is associated with inferior outcomes, mainly attributed to severe bone marrow failure [2]. However, iron toxicity, due frequent RBCT or ineffective erythropoiesis, may be an additional negative prognostic factor [3,4,5,6]. Recently, much progress has been made unraveling metabolism. The peptide hormone hepcidin key regulator by...
Abstract Myelodysplastic syndromes (MDS) are in the majority of cases characterized by anemia. Both anemia and MDS per se may directly contribute to impairments health-related quality life (HRQoL). In this study, we aimed investigate anemia-independent impact on HRQoL. We evaluated participants (≥ 50 years) from large population-based Lifelines cohort ( N = 44,694, mean age 59.0 ± 7.4 years, 43.6% male) European Registry (EUMDS) 1538, 73.4 9.0 63.0% male), which comprises a lower-risk...
Hypothyroidism is associated with a decreased health-related quality of life (HRQoL). We hypothesized that individuals hypothyroidism (defined as use thyroid hormone (TH)) and especially those having an impaired HRQoL are characterized by high prevalence comorbid disorders the impact comorbidity on synergistic. Presence was based data obtained using structured questionnaires, physical examination, biochemical measurements verified medication use. Single morbidities were clustered into 14...
Complete blood cell counts, including differentials, are widely available and change on aging. Peripheral counts outside the normal range have previously been associated with increased mortality rates a number of comorbid conditions. However, data about association between count abnormalities, other than anemia, health-related quality life (HRQoL) scarce. We investigated abnormalities in (differential) HRQoL 143 191 community-dwelling individuals from prospective population-based Lifelines...
Anaemia is highly prevalent in the general population, particularly elderly.1-3 Diminished haemoglobin concentrations, a marker of anaemia, are known to strongly impact health-related quality life, most prominently impairing physical functioning.4, 5 This negative on perceived functioning pronounced among older individuals, (i.e. ≥60 years)5. Indeed, previous studies have revealed that low concentrations associated with less performance and muscle strength patient population.6, 7 Although...
Abstract Background: Measurement of thyroid peroxidase autoantibodies (TPOAb) is used to confirm a diagnosis Hashimoto’s hypothyroidism. Presence TPOAb may predict future dysfunction, and also associated with adverse pregnancy outcomes worse quality life. Methods: We evaluated the performance four two thyroglobulin antibodies (TgAb) assays in 71 patients presumed or established disorder large variety concentrations (range < 33-3204 IU/ml, originally measured Thermo Fisher Phadia Cap...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Advanced glycation end products (AGEs) are formed by and oxidation of proteins other molecules.1,2 Tissue AGE accumulation may be assessed the non-invasive method skin autofluorescence (SAF).2 levels have previously been linked to diabetes, diabetic (micro)vascular complications cardiovascular morbidity mortality.1,3 Accumulation AGEs increases with advancing age. It has suggested that contribute a multi system decline aging, including anemia.4 As one major hallmarks hematopoietic anemia is...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Abstract Background and Aims Post-transplant anemia is highly prevalent in kidney transplant recipients (KTRs). It known that impairs health-related quality of life, especially physical functioning. Although surmised, data about the latter are scarce. Hence, we aimed to investigate association between muscle mass strength KTRs. Method We used TransplantLines Biobank Cohort study, a prospective cohort study among all types solid organ recipients. For current stable KTRs with functional graft...