A5021413563- Atrial Fibrillation Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Iron Metabolism and Disorders
- RNA Interference and Gene Delivery
- Acute Myocardial Infarction Research
- Cardiac Health and Mental Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Pregnancy and preeclampsia studies
- Cardiac electrophysiology and arrhythmias
- Erythropoietin and Anemia Treatment
- Hematological disorders and diagnostics
- Blood groups and transfusion
- Clinical Laboratory Practices and Quality Control
- Retinoids in leukemia and cellular processes
- Folate and B Vitamins Research
- DNA and Nucleic Acid Chemistry
Gelre Hospitals
2008-2024
Tergooi
2023
KLE Society Hospital
2018
Sir Ganga Ram Hospital
2018
Erasmus University Rotterdam
1988-1994
Erasmus MC
1990
Rotterdam University of Applied Sciences
1988
There is ambiguity whether frail patients with atrial fibrillation managed vitamin K antagonists (VKAs) should be switched to a non-vitamin oral anticoagulant (NOAC). We conducted pragmatic, multicenter, open-label, randomized controlled superiority trial. Older living frailty (≥75 years of age plus Groningen Frailty Indicator score ≥3) were randomly assigned switch from international normalized ratio-guided VKA treatment an NOAC or continued treatment. Patients glomerular filtration rate...
Screening for a high cardiovascular disease (CVD) risk followed by preventive treatment can potentially reduce coronary heart disease-related morbidity and mortality. ROBINSCA (Risk Or Benefit IN CArdiovascular disease) is population-based randomized controlled screening trial that investigates the effectiveness of CVD in asymptomatic participants using Systematic COronary Risk Evaluation (SCORE) model or artery calcium (CAC) scoring. This study describes distributions trial.Individuals at...
Background Vitamin B 12 deficiency occurs frequently, especially among the elderly. However, screening for vitamin is hampered by poor sensitivity of existing total assay. Methylmalonic acid (MMA) considered as most representative indicator metabolic and used such in this study. The aim study was to validate clinical usefulness holotranscobalamin (holoTC) an initial assay a mixed patient population. Methods Three hundred sixty blood samples were collected five Dutch hospitals. holoTC serum...
Chronic haemodialysis causes blood loss and iron-deficiency. This can be corrected with intravenous preparations, e.g. sodium ferric-gluconate (FeGl). In two patents complaints of hypotension malaise during FeGl infusion coincided high levels serum iron a calculated transferrin saturation above 100%. Iron toxicity could the cause these complaints. Free is known to aggravate free radicals other reactive oxygen products that are constantly formed in body. We compared four rates regard...
Abstract The t(6;9) associated with a subtype of acute myeloid leukemia (AML) was shown to generate fusion between the 3′ part CAN gene on chromosome 9 and 5′ DEK 6. same appeared be involved in case undifferentiated (AUL) as well, where it fused SET gene. Genomic sequences around translocation breakpoint were determined two samples SET‐CAN fusion. Although coexpression markers terminal deoxynucleotidyl transferase one characteristics AML, no addition random nucleotides at could found. In...
Summary. To investigate whether the different pharmacokinetics of acenocoumarol ( t 1/2 = 11 h) and phenprocoumon 140 result in a quality anticoagulation, we studied patients from Leiden anticoagulation clinic treated between 1998 1999 for more than 16 weeks. Two hundred twenty‐eight pairs were closely matched indication oral anticoagulant therapy (OAT), age, sex date start treatment. Four fifty six with 7245 International Normalized Ratio (INR) checks yielded 230 patient‐years. Quality OAT...
The aim of our study was to assess the fetal RBC count in maternal blood during uncomplicated pregnancies from 26 weeks onward. We used a flow cytometric method specifically designed for use routine hematology analyzer. Pregnant women were recruited through midwives. participating laboratories FMH QuikQuant (Trillium Diagnostics, Brewer, ME) CELL-DYN Sapphire analyzer (Abbott Santa Clara, CA). is based on monoclonal antibody hemoglobin F. Flow data analyzed by 2 independent observers. 95th...
Abstract Background Alinity hq (Abbott) is a new high-throughput hematology analyzer that exclusively employs optical principles for detecting and enumerating blood cells. It reports 29 parameters, including six-part white cell (WBC) differential. The aim of this multicenter study was to evaluate the analytical clinical performance hq. Methods Complete count (CBC) results morphological flagging were compared CELL-DYN Sapphire 2 × 200-cell manual differential results, on 1473 whole-blood...
Abstract Background For the improvement of AF care, it is important to gain insight into current anticoagulation prescription practices and guideline adherence. This report focuses on largest Dutch subset AF-patients, derived from GARFIELD-AF registry. Methods Across 35 countries worldwide, patients with newly diagnosed ‘non-valvular’ atrial fibrillation (AF) at least one additional risk factor for stroke were included. enrolled in five, independent, consecutive cohorts 2010 until 2016....
Summary. The choice of treatment malignant lymphoma may vary considerably and is mainly determined by the pathology clinical stage. Ultrasonography currently one most sensitive techniques for evaluation cervical area. We set out to assess value ultrasound imaging when added conventional staging (physical examination, laryngoscopy, computer tomography thorax abdomen, bone marrow cytology histology) maliganant in 47 patients with untreated lymphoma. Hodgkin's disease was present 14...
Patients receiving vitamin K-antagonists are monitored by regular assessment of the International Normalized Ratio (INR). There two popular methods for therapeutic control anticoagulation in patient groups: 1) Time Therapeutic Range (TTR) assessed linear interpolation successive INR measurements; 2) cross-sectional proportion (CSP) all patients' last INRs within range. The purpose present study is to compare using data from 53 Dutch Thrombosis Centres and develop a semi-quantitative model...
Gold-induced pneumonitis is a rare complication of gold salt therapy. We describe patient with rheumatoid arthritis treated salts, who developed bilateral interstitial pulmonary abnormalities and showed dramatic response on corticosteroid Although after 4 weeks treatment corticosteroids the chest X-ray lung function were still abnormal, bronchoalveolar lavage normal cell distribution. Corticosteroid therapy was continued for 8 months since there improvement studies. This case supports view...