A5062257614- Inflammatory Bowel Disease
- Microscopic Colitis
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal motility and disorders
- Autoimmune and Inflammatory Disorders Research
- Pain Management and Placebo Effect
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Neonatal and Maternal Infections
- Gastrointestinal disorders and treatments
- Adolescent and Pediatric Healthcare
- Liver Diseases and Immunity
- Infant Nutrition and Health
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Gastrointestinal Tumor Research and Treatment
- Pharmaceutical studies and practices
- Acute Lymphoblastic Leukemia research
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Foreign Body Medical Cases
- Gut microbiota and health
- Hepatitis Viruses Studies and Epidemiology
- Airway Management and Intubation Techniques
Isala
2015-2024
Máxima Medisch Centrum
2021
Radboud University Nijmegen
2021
Amalia Kinderziekenhuis
2014-2020
Erasmus MC - Sophia Children’s Hospital
2014
Serious and fatal complications after button battery ingestion are increasing worldwide. The aim of this study is to describe serious in children the Netherlands.All pediatric gastroenterologists Netherlands performing upper endoscopies were asked report all (0-18 years) between 2008 2016 retrospectively.Sixteen reported: death massive bleeding through esophageal-aortal fistula (n = 1), esophageal-tracheal 5), stenosis (suspected) perforation mediastinitis 3), vocal cord paralysis required...
Objective In newly diagnosed paediatric patients with moderate-to-severe Crohn’s disease (CD), infliximab (IFX) is initiated once exclusive enteral nutrition (EEN), corticosteroid and immunomodulator therapies have failed. We aimed to investigate whether starting first-line IFX (FL-IFX) more effective achieve maintain remission than conventional treatment. Design this multicentre open-label randomised controlled trial, untreated a new diagnosis of CD (3–17 years old, weighted Paediatric...
Antibiotic treatment is common practice in the neonatal ward for prevention and of sepsis, which one leading causes mortality morbidity preterm infants. Although effect antibiotic on microbiota development well recognised, little attention has been paid to duration. We studied short long intravenous administration intestinal Faecal samples from 15 infants (35 ± 1 weeks gestation 2871 260 g birth weight) exposed no, (≤ 3 days) or (≥ 5 with amoxicillin/ceftazidime were collected during first...
Constipation is a frustrating symptom affecting 3% of children worldwide. A fermented dairy product containing Bifidobacterium lactis strain DN-173 010 was effective in increasing stool frequency constipated women. Our aim to assess the effects this children.In prospective randomized, double-blind, controlled trial, 159 (defecation < 3 times per week) were randomly allocated receive either that contains B (n = 79) or control 80) twice day for weeks. The primary endpoint change from baseline...
<h3>Importance</h3> Individual gut-directed hypnotherapy (HT) is effective in pediatric irritable bowel syndrome (IBS) and functional abdominal pain or (FAP[S]). It is, however, unavailable to many children. <h3>Objective</h3> To compare the effectiveness of HT by means home-based self-exercises using a CD with that individual (iHT) performed qualified therapists. <h3>Design, Setting, Participants</h3> This noninferiority randomized clinical trial follow-up 1 year after end treatment was...
Infliximab is effective for induction and maintenance of remission in children with moderately to severely active Crohn's disease (CD).To evaluate the long-term efficacy infliximab treatment paediatric CD.In this observational, multicentre study, all CD patients The Netherlands treated from October 1992 November 2009 minimal follow-up 3 months since start infliximab, were studied.One hundred fifty-two [81M; median age at 15.0 years (IQR 13.1-16.4)] received a number 10.5 infusions 6-21)....
Conventional follow-up of teenagers with inflammatory bowel diseases [IBD] is done during scheduled outpatient visits regardless how well the patient feels. We designed a telemonitoring strategy for early recognition flares and compared its efficacy conventional follow-up.We used multicentre randomized trial in patients aged 10-19 years IBD clinical remission at baseline. Participants assigned to received automated alerts complete symptom score send stool sample measurement calprotectin....
Objective: The purpose of this study was to describe the clinical experience with anti–tumor necrosis factor chimeric monoclonal antibody, infliximab, in pediatric patients Crohn disease Netherlands. Design: Descriptive. Methods: Clinical response and adverse effects infliximab were recorded for treated from October 1992 January 2003. Results: Thirty (aged 7–18 years) refractory (with or without severe fistulas) infliximab. Patients up 30 infusions. Mean follow-up 25.3 months. A total 212...
Infliximab is effective for induction and maintenance of remission in Crohn's disease. It unknown how long patients should be kept on infliximab therapy. The primary aim this study was to assess duration therapy dependency pediatric CD initially responding therapy.All treated with by gastroenterologists the Netherlands because severe luminal or fistulizing initial response were reviewed. Duration therapy, clinical adverse events recorded.Sixty-six (37 boys) 10 hospitals Mean age at start...
Lipid droplets in human milk have a mode diameter of ∼4 μm and are surrounded by native phospholipid-rich membrane. Current infant formulas (IMFs) contain small lipid (mode ∼0.5 μm) primarily coated proteins. A concept IMF was developed mimicking more closely the structure composition droplets. This randomized, controlled, double-blind equivalence trial evaluates safety tolerance with large, phospholipid–coated 3–5 containing vegetable dairy lipids healthy, term infants. Fully formula-fed...
Irritable bowel syndrome (IBS) and functional abdominal pain (syndrome) (FAP(S)) are common pediatric disorders, characterized by chronic or recurrent pain. Treatment is challenging, especially in children with persisting symptoms. Gut-directed hypnotherapy (HT) performed a therapist has been shown to be effective these children, but still unavailable many due costs, lack of qualified child-hypnotherapists because it requires significant investment time child parent(s). Home-based means...
In specialist care, fecal calprotectin (FCal) is a commonly used noninvasive diagnostic test for ruling out inflammatory bowel disease (IBD) in children with chronic gastrointestinal symptoms. The aim of this study was to evaluate the accuracy FCal IBD symptomatic primary care.We studied 2 prospective cohorts diarrhea, recurrent abdominal pain, or both: initially seen care (primary cohort) and referred (referred cohort). (index test) measured at baseline compared 1 reference standards IBD:...
Summary Background Data on cost‐effectiveness of first‐line infliximab in paediatric patients with Crohn's disease are limited. Since biologics increasingly prescribed and accompanied by high costs, this knowledge gap needs to be addressed. Aim To investigate the compared conventional treatment children moderate‐to‐severe disease. Methods We included from Top‐down Infliximab Study Kids randomised controlled trial. Children newly diagnosed were treated azathioprine maintenance either five...
Adalimumab, a humanised anti-tumour necrosis factor antibody, is an effective treatment in adult patients with refractory Crohn disease (CD). The available literature on its efficacy children remains limited. We aimed to evaluate the real-world paediatric CD and compare between infliximab (IFX) nonresponders who lost response IFX.All Dutch receiving adalimumab before age of 18 years after previous IFX therapy were identified. analysed longitudinal activity, assessed by mathematically...
Abstract Background It is important to understand the consequences of pre-emptive antibiotic treatment in neonates, as disturbances microbiota development during this key developmental time window might affect early and later life health outcomes. Despite increasing knowledge regarding detrimental effect antibiotics on gut microbiota, limited research focussed duration. We determined short long amoxicillin/ceftazidime administration immediate postnatal preterm term infants. Methods Faeces...
Methotrexate [MTX] is an immunomodulating drug that can be used to maintain remission in patients with Crohn's disease [CD], but data on efficacy and tolerability children teenagers are scarce. We evaluated the long-term of MTX monotherapy after thiopurine therapy paediatric CD patients. A multicenter cohort users who stopped thiopurines due ineffectiveness or intolerance between 2002 2012 were included followed for at least 12 months. Relapse-free use was defined as steroid biologics-free...
ABSTRACT Background and Objective: Allowing children with inflammatory bowel disease (IBD) to live subnormal hemoglobin (Hb) levels affects their quality of life. The therapeutic approach normalize Hb varies according the cause IBD‐associated anemia. In exclusive iron‐deficiency anemia (IDA) repletion iron stores is obligatory, whereas controlling inflammation treatment choice for chronic (ACD). daily practice focus on control intestinal inflammation, spontaneous hematological recovery...
Human milk comprises large fat globules enveloped by a native phospholipid membrane, whereas infant formulas contain small, protein-coated lipid droplets. Previous experimental studies indicated that mimicking the architecture of human droplets in formula (IMF) alters metabolism with lasting beneficial impact on later metabolic health. To evaluate follow-up (FU) study randomized, controlled trial whether Concept IMF large, phospholipid-coated enriched dairy lipids beneficially impacts...
No studies have been performed in which therapeutic regimens compared between mild and moderate-to-severe pediatric Crohn's disease (CD) at diagnosis. The aim was to analyze CD activity diagnosis, its influence on pediatrician's prescribing behavior, clinical outcome 5 years later.In a retrospective multicenter study we divided patients diagnosis into or moderate-severe disease. We initial therapies, duration of first remission, number exacerbations, height-for-age weight-for-height...
In children with symptoms suggestive of inflammatory bowel disease (IBD) who present in primary care, the optimal test strategy for identifying those require specialist care is unclear. We evaluated following three strategies to determine which was referring suspected IBD care: 1) alarm alone, 2) plus c-reactive protein, and 3) fecal calprotectin.A prospective cohort study conducted, including chronic gastrointestinal referred pediatric gastroenterology. Outcome defined as confirmed by...
Primary sclerosing cholangitis (PSC) is a rare bile duct disease strongly associated with inflammatory bowel (IBD). Whole-exome sequencing (WES) has contributed to understanding the molecular basis of very early-onset IBD, but protein-altering genetic variants have not been identified for PSC. We performed WES in patients diagnosed PSC ≤ 12 years investigate contribution PSC.In this multicentre study, was on 87 DNA samples from 29 patient-parent trios selected (minor allele frequency < 2%)...