A5061375305- Inflammatory Bowel Disease
- Microscopic Colitis
- Appendicitis Diagnosis and Management
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Intestinal Malrotation and Obstruction Disorders
- Anorectal Disease Treatments and Outcomes
- Pregnancy and Medication Impact
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Diagnosis and treatment of tuberculosis
- IL-33, ST2, and ILC Pathways
- Colorectal and Anal Carcinomas
- Hidradenitis Suppurativa and Treatments
- Autoimmune and Inflammatory Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Infant Nutrition and Health
- Endometriosis Research and Treatment
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Ovarian cancer diagnosis and treatment
Amsterdam University Medical Centers
2019-2025
University of Amsterdam
2019-2025
University of Otago
2022
Amsterdam UMC Location University of Amsterdam
2022
Intestinal ultrasound [IUS] is an accurate, patient-centreed monitoring tool that objectively evaluates Crohn's disease [CD] activity. However no current, widely accepted, reproducible activity index exists to facilitate consistent IUS identification of inflammatory The aim this study identify key parameters CD inflammation on IUS, evaluate their reliability, and develop reflecting segmental
Intestinal ultrasound [IUS] is a promising and non-invasive cross-sectional imaging modality in the diagnosis monitoring of ulcerative colitis [UC]. Unlike endoscopy, where standardized scoring for evaluation disease activity widely used, UC with IUS currently unavailable. Therefore, we conducted study to assess reliability among expert sonographists order identify robust parameters.Thirty patients both clinically active [25] quiescent [five] were included. Six sonographers first agreed upon...
To assess treatment response, objective measures are superior to clinical improvement in Crohn's disease [CD]. Intestinal ultrasound [IUS] is an attractive, non-invasive alternative endoscopy, demonstrating early transmural changes after initiation. Therefore, we investigated IUS and contrast-enhanced [CEUS] predict [early] endoscopic response.Consecutive patients with endoscopically active CD, starting anti-TNFα therapy, were included. Clinical, biochemical, IUS, CEUS parameters at baseline...
Intestinal ultrasound [IUS] is useful for assessment of inflammation, complications, and treatment follow-up in inflammatory bowel disease [IBD] patients. We aimed to study outcomes impact on management point-of-care [POC] IUS IBD patients.Two patient cohorts undergoing POC [January 2016-July 2018 October 2019-December 2019] were included retrospectively. Disease after was analysed compared with symptoms, biomarkers, additional imaging within 8 weeks from IUS. To differences use over time,...
Active disease in inflammatory bowel patients during pregnancy is associated with poor maternal and fetal outcomes. Objective evaluation of activity a core strategy IBD, noninvasive modalities are preferred. We aimed to evaluate feasibility accuracy intestinal ultrasound (IUS) objectify throughout pregnancy.Pregnant known IBD were included followed for clinical activity, fecal calprotectin (FCP) IUS every trimester. Feasibility was assessed all colonic segments terminal ileum (TI)....
Objectives: Currently, there is no consensus on how to score Crohn disease (CD) activity assessed by intestinal ultrasound (IUS) in children. This study aimed design an easy-to-use IUS for pediatric CD. Methods: Children undergoing ileo-colonoscopy CD assessment underwent the day before ileo-colonoscopy, with simple endoscopic (SES-CD). features were compared SES-CD segmental level. Multiple regression analyses, separately terminal ileum (TI) and colon, done assess predictors of develop a...
Abstract Background The submucosa is the most responsive wall layer in monitoring of treatment response ulcerative colitis (UC) with intestinal ultrasound (IUS).1 However, persistent submucosal thickening, often seen combination hyperechogenicity, could be associated non-response.2 We aimed to understand these transmural changes UC by correlating IUS findings histopathology colectomy specimens. Methods In total, 118 patients were included: (cohort 1) 19 and 52 controls without inflammatory...
Abstract Background Endoscopic healing (EH) is recognised as a long-term treatment goal for patients with ulcerative colitis (UC).1 We investigated whether transmural (TH) in UC assessed by intestinal ultrasound (IUS) associated improved outcomes compared to EH alone. Methods performed retrospective study on left-sided or extensive stable maintenance who had (Mayo Sub score [MES] ≤1) and an within six months of endoscopy no alterations between IUS endoscopy. Patients proctitis...
Abstract Background Crohn’s disease (CD) strictures exhibit varying levels of inflammation and chronicity. Treatment decisions are likely to improve when the predominant phenotype is known1. Intestinal ultrasound (IUS) allows transmural evaluation with potential characterize this phenotype2. Here, we evaluated whether conventional intestinal in combination advanced modalities (contrast-enhanced (CEUS) shear-wave elastography (SWE)) accurate characterizing CD strictures. Methods patients a...
Intestinal ultrasound (IUS) is an emerging modality in monitoring disease activity ulcerative colitis (UC). Here, we aimed to identify early IUS predictors of treatment response as evaluated by endoscopy and assessed the kinetics changes.This prospective, longitudinal study included UC patients with endoscopic (endoscopic Mayo score [EMS] ≥2) starting anti-inflammatory treatment. Clinical scores, biochemical parameters were at baseline (W0), week 2 (W2), W6(W6), time second (W8-W26). Per...
Abstract Background and Aims Previous literature suggests that faecal calprotectin (FC) discriminates Crohn's disease perianal fistulas from cryptoglandular fistulas, irrespective of luminal disease. This study aims to prospectively validate this analyse if increased local fistula levels are associated with characteristics. Methods In prospective study, all consecutive patients an active undergoing examination under anaesthesia were included. Faecal tract scraping determined. The primary...
Abstract Background A primary objective in the management of Crohn's disease (CD) is prevention bowel tissue damage. The Lémann index (LI) characterizes structural damage based on magnetic resonance enterography (MRE) or computed tomography (CTE) and, for colonic CD, colonoscopy. Intestinal ultrasonography (IUS) provides a non-invasive imaging alternative, though its role LI assessment remains unexplored. This study aimed to establish consensus parameters and standardized acquisition scoring...
Abstract Background Up to 40% of patients with acute severe ulcerative colitis (ASUC) do not respond infliximab (IFX)(1). Insufficient drug exposure low IFX serum concentrations is associated non-response (1, 2). We investigated whether personalised TDM-driven induction dosing was superior standard dosing. Methods In this prospective open-label, multi-centre randomised controlled trial (Netherlands, Norway and Ireland), hospitalised adult IFX-naïve steroid-refractory ASUC were 1:1 (SD) or...
Abstract Objectives The histopathological composition of a stricture impacts clinical treatment choice. Therefore, imaging biomarkers that can distinguish predominantly inflammatory from chronic (ie non-inflammatory) are highly relevant. aim our study was to determine whether it is possible and mixed) strictures using quantified motility measured on cine-MRI in CD patients. Methods In this prospective cross-sectional consecutive patients scheduled for small bowel resection underwent 2D prior...
Abstract Background There is currently no consensus on the definition of an abnormal intestinal ultrasound (IUS) for children with ulcerative colitis (UC). This cross-sectional study aimed to externally validate and compare 2 existing IUS indices in UC. Methods Children undergoing colonoscopy UC assessment underwent day before colonoscopy, assessed Mayo endoscopic subscore. The UC-IUS index Civitelli were compared score ascending, transverse, descending colon. area under receiver-operating...
ABSTRACT Objectives: Training healthcare physicians to perform intestinal ultrasound (IUS) during outpatient visits with equal accuracy as radiologists could improve clinical management of IBD patients. We aimed assess whether a healthcare‐physician can be trained IUS, compared experienced in children iBD, and inter‐observer agreement. Methods: Consecutive children, 6 18 years or suspicion IBD, who underwent ileo‐colonoscopy were enrolled. iUS was performed independently by radiologist 1...