A5085045793- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Diagnosis and treatment of tuberculosis
- Pharmaceutical studies and practices
- Hepatitis B Virus Studies
- Biosimilars and Bioanalytical Methods
- Neurogenetic and Muscular Disorders Research
- Neurological diseases and metabolism
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal motility and disorders
- Child Nutrition and Feeding Issues
- Bone health and treatments
- Hepatitis C virus research
- Obesity and Health Practices
- Gastrointestinal disorders and treatments
- Nutrition and Health in Aging
- Craniofacial Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Diverticular Disease and Complications
- Cancer, Hypoxia, and Metabolism
Singapore General Hospital
1992-2025
Universiti Putra Malaysia
2024
Changi General Hospital
2019
St Mary's Hospital
2017
Imperial College Healthcare NHS Trust
2017
St. Mary's Hospital
2017
Imperial College London
2017
Abstract Background Suboptimal control of inflammatory bowel disease (IBD) can lead to clinical relapse and progression. The STRIDE-II consensus in 2021 encompasses recommendations for short term, intermediate, long-term targets involving clinical, biochemical endoscopic remission respectively a ‘Treat Target’ strategy improve IBD-related outcome . We aim assess the rates endoscopy assessments our cohort. Methods This was multi-center retrospective study four hospitals Singapore. Between 1...
Abstract Background Endoscopic healing (EH) is recognised as a long-term treatment goal for patients with ulcerative colitis (UC).1 We investigated whether transmural (TH) in UC assessed by intestinal ultrasound (IUS) associated improved outcomes compared to EH alone. Methods performed retrospective study on left-sided or extensive stable maintenance who had (Mayo Sub score [MES] ≤1) and an within six months of endoscopy no alterations between IUS endoscopy. Patients proctitis...
Background: Chronic hepatitis B (CHB) infection and nonalcoholic fatty liver disease (NAFLD) are diseases which may lead to hepatocellular carcinoma (HCC) formation. Both entities have been attributed independently increase risk of HCC development. While concomitant hepatic steatosis in patients with CHB becoming more frequent view increasing NAFLD prevalence, there is no conclusive evidence linking presence increased infection. This study explores the association among CHB-infected...
Abstract Background Dietary beliefs and behaviors in IBD patients may affect both clinical outcome psychosocial aspect of patients’ lives. New emerging studies have shown varying efficacy different diets inducing maintaining remission patients. This study aims to investigate the dietary beliefs, barriers, acceptability diet among Asia-Pacific region. Methods A multi-centre survey was conducted across 4 countries Asia-Pacific. An anonymized online electronic disseminated at 10 participating...
Abstract Background Ustekinumab (UST) is an effective biologic for treatment of Inflammatory Bowel Disease (IBD). However, some patients treated with UST have suboptimal clinical response standard induction and maintenance doses. In patients, strategies such as dose intensification (DI) reinduction been used to improve response. The aims this study are identify factors associated DI our IBD cohort also effectiveness during DI. Methods This was a retrospective on Crohn’s disease (CD)...
Abstract Background Elderly onset inflammatory bowel disease (EOIBD) has variable characteristics in the published literature. We performed this study to report characteristics, treatment exposure, and clinical outcomes of EOIBD compared adult IBD (AOIBD) Singapore. Methods This is a retrospective involving patients seen at two tertiary hospitals Singapore from January 2020 September 2023. Patients were identified National registry. Those with missing data on age diagnosis excluded. Data...
What is already known on this topic?• IGSF1 mutation the most common cause of X-linked recessive mild to moderate isolated central hypothyroidism.• It associated with macroorchidism delayed pubertal testosterone rise, large birth weight, increased body mass index, low prolactin and transient growth hormone deficiency study adds?• A novel c.3467T>A variant was found in 2 siblings hypothyroidism macroorcidism, first report South East Asia.• Genetic evaluation for important patients unexplained...
Abstract Background and Aims Ustekinumab (UST) is an effective biologic for treatment of inflammatory bowel disease (IBD). However, some patients treated with UST have suboptimal clinical response standard dosing. The aims this study were to determine the effectiveness dose intensification (DI), identify factors associated DI, cumulative incidence DI persistence among patients. Methods Clinical data Crohn's (CD) ulcerative colitis (UC) who received from September 2017 October 2022 in...
Abstract Background The expanding therapeutic armamentarium for inflammatory bowel disease (IBD) has drastically improved the clinical outcomes of patients with both Crohn’s Disease (CD), and Ulcerative Colitis (UC). However, data in newly diagnosed IBD era biologics recent decades remains limited. We aim to compare Singapore between conventional (originator Anti-TNF) those during newer over a 14-year period. Methods This is multi-centre retrospective observational cohort study. Baseline...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
INTRODUCTION: Meckel's diverticulum is a common congenital abnormality of the small intestine secondary to vitello-intestinal duct. It commonly presents as hematochezia and abdominal pain in young children particularly those less than 2 years old. CASE DESCRIPTION/METHODS: A 26 old lady presented Emergency Department with history for days. The was mainly paraumbilical colicky nature it present intermittently past 6 months. One day prior this visit, she treated acute gastroenteritis by...
INTRODUCTION: The recommended infusion time for infliximab inflammatory bowel disease (IBD) is 2 hours or more. Time spent on receiving infusions in the hospital disrupts school and work activities. Significant nursing also which increases healthcare costs. Shortening to over 1 hour has been shown be safe potential decrease hospital. This study aims determine safety effectiveness of this accelerated protocol patients with IBD Southeast Asia. METHODS: We conducted a retrospective Crohn's (CD)...
Inflammatory bowel disease (IBD) is a chronic, idiopathic, inflammatory disorder of the gastrointestinal tract that typically categorised into Crohn’s and ulcerative colitis. Traditionally, IBD was regarded as western world. Newer epidemiological studies suggest that, with turn 21st century, has become global rising incidence in newly industrialised countries Asia, Africa, South America. There are also advances diagnostics therapeutic armamentarium IBD. In this review, we provide an update...