A5037545952- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- CRISPR and Genetic Engineering
- Appendicitis Diagnosis and Management
- Pluripotent Stem Cells Research
- Intraperitoneal and Appendiceal Malignancies
- Minimally Invasive Surgical Techniques
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- Dermatological and COVID-19 studies
- Child Development and Digital Technology
- Mitochondrial Function and Pathology
- Hormonal Regulation and Hypertension
- Cancer Immunotherapy and Biomarkers
- Adolescent and Pediatric Healthcare
- Rheumatoid Arthritis Research and Therapies
- Ion Transport and Channel Regulation
- Medication Adherence and Compliance
- Eosinophilic Esophagitis
- Infant Development and Preterm Care
- Liver Disease and Transplantation
- Inflammatory Bowel Disease
- Metabolism and Genetic Disorders
- Microscopic Colitis
- Ion channel regulation and function
Agency for Science, Technology and Research
2009-2023
Singapore Institute for Clinical Sciences
2023
Singapore General Hospital
2021
Bioprocessing Technology Institute
2009-2010
University of California, San Francisco
2006-2007
The University of Texas Southwestern Medical Center
2006
University of California, Davis
2006
Center for Human Genetics
2006
Cancer Research Center
2006
University of Hong Kong
1999
Importance Research evidence is mounting for the association between infant screen use and negative cognitive outcomes related to attention executive functions. The nature, timing, persistence of time exposure on neural functions are currently unknown. Electroencephalography (EEG) permits elucidation correlates associated with impairments. Objective To examine associations time, EEG markers, school-age using mediation analysis structural equation modeling. Design, Setting, Participants This...
Cytochrome P450 (P450) eicosanoids regulate vascular tone, renal tubular transport, cellular proliferation, and inflammation. Both the CYP4A ω-hydroxylases, which catalyze 20-hydroxyeicosatetraenoic acid (20-HETE) formation, soluble epoxide hydrolase (sEH), catalyzes epoxyeicosatrienoic (EET) degradation to dihydroxyeicosatrienoic acids (DHETs), are induced upon activation of peroxisome proliferator-activated receptor α (PPARα) by fatty fibrates. In contrast, CYP2C epoxygenases, responsible...
Abstract Human embryonic stem cells (hESCs) have the capacity to remain pluripotent and self-renew indefinitely. To discover novel players in maintenance of hESCs, we previously reported generation monoclonal antibodies that bind cell surface markers on not mouse or differentiated embryoid bodies. In this study, identified antigen target one such antibody as epithelial adhesion molecule (EpCAM). undifferentiated EpCAM is localized Octamer 4 (OCT4)-positive cells, its expression...
Abstract Introduction Mobile Inpatient Care at Home (MIC@Home) is an alternative acute care model that offers within patients' homes instead of in traditional hospital settings. This qualitative study seeks to investigate existing perspectives on MIC@Home and the challenges associated specifically with its provision pharmacy services, propose suitable recommendations for enhancement upscaling such services projected timelines. Methods Data was collected using semi‐structured interviews eight...
1 The role of cyclo-oxygenase (COX) in the regulation anion secretion (measured as short- circuit current, Isc) cultured epididymal epithelia from immature rats was investigated. 2 COX inhibitors attenuated increase caused by bradykinin (LBK) but had no effect on that PGE2, suggesting prostaglandin synthesis mediates secretory response tissues to LBK. 3 apparent IC50 values for indomethacin, piroxicam and L-745,337 inhibiting LBK-induced Isc were 0·14, 1·34 15·7 μM, respectively. This order...
Proliferation of smooth muscle cells is implicated in cardiovascular complications. Previously, a urea-based soluble epoxide hydrolase inhibitor was shown to attenuate cell proliferation. We examined the possibility that alkanoic acids activate nuclear receptor peroxisome proliferator-activated alpha (PPARalpha) and role PPARalpha proliferation.Alkanoic transactivated PPARalpha, induced binding its response element, significantly expression PPARalpha-responsive genes, showing their function...
The saturated C20 isoprenoid phytanic acid is physiologically derived from phytol released in the degradation of chlorophyll. presence a C-3 methyl group this substrate blocks normal β-oxidation, so primarily occurs by initial peroxisomal α-oxidation to shift register group. However, individuals with Refsum9s disease are genetically deficient required phytanoyl-CoA α-hydroxylase and suffer neurological pathologies caused accumulation acid. Recent work has shown that can also be catabolized...
Dietary γ-linolenic acid (GLA), a ω-6 polyunsaturated fatty found in borage oil (BOR), lowers systolic blood pressure spontaneously hypertensive rats (SHRs). GLA is converted into arachidonic (AA) by elongation and desaturation steps. Epoxyeicosatrienoic acids (EETs) 20-hydroxyeicosatetraenoic (20-HETE) are cytochrome P450 (P450)-derived AA eicosanoids with important roles regulating pressure. This study tested the hypothesis that pressure-lowering effect of GLA-enriched diet involves...
The seminal report from Takahashi and Yamanka in 2006 describing the reprogramming of somatic cells to induced pluripotent stem (iPS) [1] marked beginning a new field research, resulting hundreds publications short 3 years.Among other things, promise iPS cell therapy circumvents many ethical concerns associated with embryonic (ES) autologous patient-specific can be generated.Nonetheless, jury is still out on extent which ES are functionally equivalent.This review focuses genetic functional...
Abstract Background Immunomodulators (IMs) such as azathioprine are the cornerstone in treatment of inflammatory bowel disease (IBD). However, they associated with significant toxicity and requires close monitoring for side effects, which puts a stretch on our physician clinics. The pharmacist-run Immuno Clinic (IMC) was set up 2016 to assist stable patients initial titration phase IMs so that physicians able focus their time energy more complex diseases. objective this study is demonstrate...