A5085899869- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Acute Lymphoblastic Leukemia research
- Liver Disease Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Nutrition and Health in Aging
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- Colorectal Cancer Screening and Detection
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Pharmacological Effects of Natural Compounds
- Celiac Disease Research and Management
- Diet, Metabolism, and Disease
- Pregnancy and Medication Impact
- Travel-related health issues
- Vaccine Coverage and Hesitancy
- Global Health and Surgery
- Ultrasound in Clinical Applications
- Ultrasound and Hyperthermia Applications
Singapore General Hospital
2015-2024
Parkway East Hospital
2021
University of Calgary
2017-2018
Duke-NUS Medical School
2018
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic and closely related to metabolic syndrome its risk factors. Worldwide, epidemiological studies have reported NAFLD prevalence rates of 5% 30% depending on geographical variations. While data suggest a progressively increasing factors in Singapore, there are limited about per se community. We aim explore perceptions Singapore.Attendees at gastroenterology public forum were enrolled cross-sectional observational study...
Ustekinumab (UST), an anti-IL12/23 inhibitor is indicated for moderate-to-severe Crohn's disease (CD). However, it unclear if patients treated with UST are at increased risk postoperative complications.To evaluate the safety outcomes in UST-treated CD patients.A multicentre cohort study of two tertiary care centres (University Calgary, University Alberta, Canada) undergoing abdominal surgery between 2009 and 2016 was performed. Postoperative were compared against a control anti-TNF-treated...
Background: Genetic variants of TPMT and NUDT15 have been reported to predict the inter-patient variability in response toxicity profiles patients receiving thiopurine therapy. However, clinical utility genotyping guiding doses has questionable, part due underlying differences prevalence both Caucasian Asian populations. Several associated with thiopurine-induced leukopenia, particularly cohorts. So far, none a multiethnic population. Aim: To investigate associations between myelotoxicity...
Maintaining disease remission improves outcomes for pregnant women with Crohn's (CD). As symptoms may correlate poorly activity in the gravid state, we investigated utility of bowel sonography during pregnancy to assess activity.We conducted a prospective observational cohort study CD undergoing between July 1, 2012, and December 2016. Clinically active was defined using standardized clinical indices (Harvey Bradshaw Index >4 disease). Sonographic findings were graded as inactive (normal,...
Abstract Background Dietary beliefs and behaviors in IBD patients may affect both clinical outcome psychosocial aspect of patients’ lives. New emerging studies have shown varying efficacy different diets inducing maintaining remission patients. This study aims to investigate the dietary beliefs, barriers, acceptability diet among Asia-Pacific region. Methods A multi-centre survey was conducted across 4 countries Asia-Pacific. An anonymized online electronic disseminated at 10 participating...
Background and aims: Comorbidities, polypharmacy, malignancies, infections complicate management of elderly patients with inflammatory bowel diseases (IBD). This study assessed gastroenterologists’ preference in the prescription medications or surgery to IBD, factors associated their choices. Methods An international case-based survey was conducted that presented three cases steroid-dependent ulcerative colitis assessing young-age versus elderly-age patients, without comorbidity. Physician...
The introduction of ustekinumab, an interleukin [IL]12/23 p40 inhibitor, to the therapeutic armamentarium Crohn’s disease has provided a much needed treatment option for patients who have failed conventional biologics with anti-tumour necrosis factor [TNF] and anti-integrin agents. Despite targeting two major cytokine pathways, side effect profile ustekinumab appears be favourable in clinical trials. In particular, risk tuberculosis infection was observed lower than received anti-TNF...
Objectives Prevalence of malnutrition among ambulatory inflammatory bowel disease (IBD) patients in Singapore is unknown. We aimed to evaluate the prevalence IBD at risk (ARMN) using Malnutrition Universal Screening Tool (MUST) and its clinical outcomes. Methods were recruited from March June 2018 followed up for 6 months. ARMN defined as having a MUST score 2 or more compared with those not (non‐ARMN). Results Altogether 217 recruited, including 128 (59.0%) ulcerative colitis (UC) 89...
With increasing use of biological therapies and immunosuppressive agents, patients with inflammatory bowel disease[IBD] have improved clinical outcome international travel in this group is becoming common. Adequate pre-travel advice important. We aim to determine the proportion gastroenterologists who provided advice, assess their management strategies for on visiting tuberculosis[TB]-endemic areas.A 57-question survey was distributed IBD physicians 23 countries. collected physicians'...
Real-world clinical data on the use of vedolizumab in patients with inflammatory bowel disease (IBD) is lacking Asian populations. We aim to report efficacy and safety outcomes a nation-wide cohort Singapore. A retrospective study adult IBD from 6 largest local hospitals who completed induction between 2015 2018 was conducted. The primary outcome measure steroid-free remission (SFCR) at 14, 24 54 weeks after initiation therapy. SFCR defined as complete tapering steroids absence symptoms...
Ustekinumab (UST), an anti IL12/23 inhibitor, has been recently approved for the treatment of moderate to severe Crohn's disease (CD) in Europe and United States. In Canada, UST used off-label CD patients failing anti-TNF therapy. We aim review postoperative safety outcomes UST-treated which not previously reported. A retrospective chart at two tertiary care academic centres (University Calgary, University Alberta) who underwent abdominal surgery between April 1, 2013 July 31, 2016 was...
Abstract Background Ustekinumab is the latest therapeutic option for Crohn’s disease (CD). Efficacy and safety outcomes of its use in Asia CD population, however, have not been reported. Methods Patients with who received minimum 14 weeks UST were included. The primary outcome was percentage patients achieved remission by global physician assessment, GPA [defined Steroid Free Remission (Harvey Bradshaw Index ≤4 absence systemic corticosteroid), stool calprotectin <250 μg/g CR p...
Objective There is debate on the best method of colorectal cancer (CRC) surveillance in inflammatory bowel disease (IBD). We aimed to examine how gastroenterologists around world practice CRC and manage dysplastic lesions IBD. Methods A 22‐question survey was emailed from 34 countries. It included questions resources for, frequency mode surveillance, management dysplasia. Fisherʼs exact test logistic regression were used evaluate differences among respondents various domains. Results 217...
Background: There is a considerable overlap between symptoms of irritable bowel syndrome (IBS) and inflammatory disease (IBD). It important to have access non-invasive, safe, low cost diagnostic tools differentiate IBD from functional abdominal such as IBS, avoid unnecessary invasive investigations including endoscopy. Point care ultrasound (POCUS) the not widely accessible in North America, but routinely used Europe. The aim this study was evaluate accuracy POCUS detection luminal...
Data on the natural history of inflammatory bowel disease(IBD) in Asia are limited. We aimed to determine clinical features and outcomes IBD patients from largest centre Singapore. collected data 581 with (334 ulcerative colitis [UC], 245 Crohn’s disease [CD], 2 unclassified) 1970 2017 using hospital administrative records. Disease phenotype, complications, use medications, surgery were analysed. The median age CD UC was 45 (interquartile range (IQR), 30–59) years 56 (IQR, -65) years,...
Background: Although growing evidence suggests that fructose intake contributes to the development of non-alcoholic fatty liver disease (NAFLD), in NAFLD patients has not been documented locally. Objectives: The objectives this study were compare between and controls with chronic hepatitis B, ascertain whether was associated presence NAFLD. Methods: This a cross-sectional, case–control study. Thirty-four diagnosed 34 B participated 2012 2014 Singapore General Hospital outpatient setting....