A5046810443- Digestive system and related health
- Cystic Fibrosis Research Advances
- Child Nutrition and Feeding Issues
- Diet and metabolism studies
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Clinical Nutrition and Gastroenterology
- Diet, Metabolism, and Disease
- Neuroendocrine Tumor Research Advances
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal motility and disorders
- Infant Nutrition and Health
- Pancreatitis Pathology and Treatment
- Metabolism and Genetic Disorders
- Nutrition and Health Studies
- Celiac Disease Research and Management
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Pancreatic function and diabetes
- Child and Adolescent Health
- Neonatal Respiratory Health Research
- Gastrointestinal disorders and treatments
- Childhood Cancer Survivors' Quality of Life
- Microscopic Colitis
- Gut microbiota and health
Uniwersytet Kaliski im. Prezydenta Stanisława Wojciechowskiego
2021-2022
AGH University of Krakow
2022
Poznan University of Medical Sciences
2009-2021
Uniwersytecki Szpital Dziecięcy
2015
University of Oulu
2007
University of Göttingen
1984-1997
Kiel University
1997
Universität Hamburg
1997
Health Center
1984
To evaluate the efficacy of Lactobacillus rhamnosus GG (LGG) supplementation in eliminating gastrointestinal carrier state vancomycin-resistant enterococci (VRE) colonized children, and to affect probiotic on spp. counts tract.A randomized, single-blind, placebo-controlled study. Children (0 18 y old) hospitalized at wards children's hospital who were diagnosed with VRE randomized group receiving 3 billion colony forming unit LGG/day or placebo for 21 consecutive days. A total 61 children...
AbstractBackground: The secretin-cholecystokinin (CCK) test is the gold standard in evaluation of exocrine pancreatic insufficiency. Because its invasive character, it limited value cystic fibrosis (CF) patients, especially those with severe respiratory disease. aim study was to evaluate sensitivity fecal elastase-1 relation secretin-CCK and quantitative fat excretion CF patients. Methods: comprised 28 patients (11 females 17 males) aged 4 20 years. In all determination concentration (with...
The coexistence of cystic fibrosis (CF) and celiac disease (CD) has been reported. To our knowledge there is no study directly comparing the incidence CD in CF patients to that general population at same time. There published data on genetic predisposition either. Therefore, present we aimed assess its it from population.Two hundred eighty-two were enrolled study. In 230 (the presence HLA-DQ2/ DQ8) was assessed. all patients, serological screening for conducted. with positive antiendomysial...
Juvenile polyposis syndrome (JPS) is an autosomal dominant predisposition to the occurrence of hamartomatous polyps in gastrointestinal tract.Diagnosis JPS based on numerous colon and rectum or any number with family history and, case juvenile polyps, their also outside large intestine.The caused by mutations SMAD4 BMPR1A.Products gene are involved signal transduction transforming growth factor β pathway BMPR1A protein a receptor belonging transmembrane serine/threonine kinases.Both proteins...
Cystic fibrosis (CF) is the most common cause of exocrine pancreatic insufficiency in childhood. The aim present study to evaluate correlation between genotype and CF patients. special emphasis was put on analysis mild CFTR mutations.The comprised 394 patients 105 healthy subjects (HS). Elastase-1 concentrations were measured all subjects.Severe associated with presence two gene mutations (DeltaF508, N1303K, dele 2,3 (21kb), G542X, 1717-1G-A, R533X, W1282X, 621GT, 2183AAG, R560T, 2184insA...
Objective. Inflammatory bowel disease (IBD) in children creates diagnostic and clinical challenges. Clinical data, endoscopic appearance the histopathological assessment of biopsies are essential for diagnosis. However, new methods required non-invasive follow-up. Recently, we demonstrated that dimeric isoform pyruvate kinase (PK) detected stool might serve as a potential screening tool inflamed pouch mucosa. The aim this study was to investigate whether test could be used detect intestinal...
Hamartomas are tumour-like malformations, consisting of disorganized normal tissues, typical the site tumour manifestation. Familial manifestation hamartomatous polyps can be noted in juvenile polyposis syndrome (JPS), Peutz-Jeghers' (PJS), hereditary mixed (HMPS) and PTEN hamartoma (PHTS). All aforementioned syndromes inherited an autosomal dominant manner form a rather heterogenous group both respect to number localization risk cancer development alimentary tract other organs. Individual...
Large cell calcifying sertoli tumor (LCCSCT) is an exceptionally rare neoplasm originating from sperm cord cells. The tumors have relatively low malignant potential and unlikely proceed to metastasis formation. lesions may occur in isolated form or ca. 40% of cases be associated with genetic abnormalities, by large Peutz-Jeghers syndrome Carney complex. At presentation, 20% LCCSCT are bilateral and/or multifocal. Owning characteristic skin particular hyperechoic ultrasound image the tumor,...
The genetic background and the determinants influencing disease form, course, onset of inflammatory bowel (IBD) remain unresolved. We aimed to determine NOD2 gene haplotypes their relationship with IBD occurrence, clinical presentation, onset, analyzing a cohort 578 patients IBD, including children, 888 controls. Imaging or endoscopy histopathological confirmation was used diagnose IBD. Genotyping performed assess differences in genotypic allelic frequencies. Linkage disequilibrium analyzed,...
Abstract Background Peutz-Jeghers syndrome (PJS) is a rare hereditary characterized by the occurrence of hamartomatous polyps in gastrointestinal tract, mucocutaneous pigmentation and increased risk cancer multiple internal organs. Depending on studied population, its incidence has been estimated to range from 1:200 000 even up 1:50 births. Being an autosomal disease, PJS caused most cases mutations STK11 gene. Methods The majority causative DNA changes identified patients with are small...
The roles of the many bioactive peptides in pathogenesis celiac disease remain unclear. To evaluate serum concentrations insulin, ghrelin, adiponectin, leptin, leptin receptor, and lipocalin-2 children with who do not adhere to a gluten-free diet (GFD, intermittent adherence).Prepubertal, pubertal, adolescent were included this study (74 girls 53 boys on GFD 80 40 off GFD).Insulin levels prepubertal (9.01±4.43 μIU/mL), pubertal (10.3±3.62 (10.8±4.73 μIU/mL) higher than those (5.88±2.02,...
Tetrahydrobiopterin (BH4) has been recently approved as a treatment of patients with phenylketonuria. However, confirmation BH4-responsiveness, it might require very expensive trial BH4 or prolonged BH4-loading procedures. The selection eligible for BH4-therapy by means genotyping the PAH gene mutations may be recommended complementary approach. A population-wide study was carried out in 1286 Polish phenyloketonuria-patients. aim to estimate demand and cover prospectively National Health...
The presented study assesses levels of specific knowledge the disease among cystic fibrosis (CF) patients and their families, evaluates effectiveness a targeted, education programme.A cross-sectional survey 462 families with CF child evaluated disease. A one year follow up 200 assessed an educational programme developed to correct gaps, errors misconceptions identified in previously administered survey. Self-administered, comprehensive, 5-domains, 45-item multiple-choice Disease Knowledge...
Abstract Background Most methods used for the assessment of severe steatorrhea in cystic fibrosis (CF) are sensitive. In fact, tests show their usefulness a borderline zone results. Yet, existing data related to acid steatocrit (AS) still contradictory. Therefore, present study we have aimed assess CF patients without or with mild steatorhea (<10 g/day) and evaluate applicability AS such subset patients. Patients Methods fifty‐five patients, AS, fecal fat concentration (FFC) excretion...
Pancreatic polypeptide (PP) was measured in 74 patients with normal and 42 abnormal pancreatic function under fasting conditions (before after duodenal intubation) following secretin cholecystokinin (CCK) stimulation. Fasting PP values of severe but not moderate exocrine insufficiency were significantly lower than those controls. Duodenal intubation led to a significant increase values. Both CCK and, lesser extent, an compared controls Therefore, while serum levels low stimulation indicate...