A5065326160- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
- Peripheral Nerve Disorders
- Pelvic and Acetabular Injuries
- Heavy Metal Exposure and Toxicity
- Genetic factors in colorectal cancer
- Orthopedic Surgery and Rehabilitation
- Trace Elements in Health
- Bone health and osteoporosis research
- Nerve Injury and Rehabilitation
- Management of metastatic bone disease
- Bone health and treatments
- Cancer Genomics and Diagnostics
- Digestive system and related health
- Trauma Management and Diagnosis
- Pharmacological Effects of Medicinal Plants
- Pluripotent Stem Cells Research
- Myofascial pain diagnosis and treatment
- Spinal Cord Injury Research
- Health, Work, and Social Studies in Poland
- Cervical and Thoracic Myelopathy
- Bone Tumor Diagnosis and Treatments
Poznan University of Medical Sciences
2016-2025
National Institute of Geriatrics, Rheumatology and Rehabilitation
2016
Ischemic heart disease, also known as coronary artery disease (CAD), poses a challenge for regenerative medicine. iPSC technology might lead to breakthrough due the possibility of directed cell differentiation delivering new powerful source human autologous cardiomyocytes. One factors supporting proper maturation is in vitro culture duration. In this study, primary skeletal muscle myoblasts were selected myogenic type reservoir genetic reprogramming. Skeletal have similar ontogeny...
Background and objectives: The course of SARS-CoV-2 (COVID-19) is still under analysis. majority complications arising from the infection are related to respiratory system. adverse effect viral on bone joint tissue has also been observed. Materials Methods: We present a group 10 patients with degeneration large joints adjacent epiphyses long bones spine, background infarctions avascular necrosis (AVN) immediately after COVID-19 virus. In MR imaging, changes in characteristics AVN were...
Abstract Familial adenomatous polyposis (FAP) is a well-defined autosomal dominant predisposition to the development of in colon and rectum at unusually early ages. The first symptoms FAP are diarrhea blood stool. Weight loss weaknesses occur after advanced tumour. incidence disorder one per 10000 newborns. There high levels heterogeneity with regard number timing occurrence polyps. classical form characterized by presence more than 100 polyps, which appear second decade life. average time...
Degenerative changes are characterized by the formation of vertebral osteophytes, hypertrophy facet joints, and narrowing intervertebral space. This study aimed to investigate concentrations trace elements (Al, As, Se, Zn, Fe, Mo, Cu) in spinal tissues (intervertebral discs, muscle, bone) patients with degenerative lumbar spine disease (DLSD) their potential associations disease. The research involved 13 undergoing surgery for symptomatic element were analyzed using chemical radiographic...
Background: S1 nerve roots are difficult to approach during percutaneous procedures for the diagnostic and treatment of low back pain with radicular symptoms. This is harder in older patients obscure anatomies, due bone density overimposing degenerative changes facets deformations. The otherwise straightforward procedure lumbar roots, placing needle proximity under fluoroscopic guidance, becomes quite a challenge. Case presentation: In proposed technique, initial target lower part facet...
The aim of the study was to determine content particular elements Ca, Mg, P, Na, K, Zn, Cu, Fe, Mo, Cr, Ni, Ba, Sr, and Pb in proximal femur bone tissue (cancellous cortical bone) 96 patients undergoing total hip replacement for osteoarthritis using ICP-AES FAAS analytical techniques. interdependencies among these their correlations depended on factors including age, gender, place residence, tobacco consumption, alcohol exposure environmental pollution, physical activity, type degenerative...
The prevalence of lower back pain and radicular in the population requires more accurate diagnostic methods to effectively prevent treat patients with these ailments. In this paper, we focused on one causes pain—lumbar foraminal stenosis (LFS). aim study is assess morphometry intervertebral canals lumbar spine at levels L4/L5 L5/S1 motor segments. obtained results showed correlations between circumference surface area individual cross-sections determined approximate shape root canal its...
Hamartomas are tumour-like malformations, consisting of disorganized normal tissues, typical the site tumour manifestation. Familial manifestation hamartomatous polyps can be noted in juvenile polyposis syndrome (JPS), Peutz-Jeghers' (PJS), hereditary mixed (HMPS) and PTEN hamartoma (PHTS). All aforementioned syndromes inherited an autosomal dominant manner form a rather heterogenous group both respect to number localization risk cancer development alimentary tract other organs. Individual...
Trace element (TE) analysis in human tissue has the dual purpose of assessing environmental pollution and metabolism. In literature, bone TE is common, but studies intervertebral disc (IVD) are lacking. The aim study was evaluation difference concentration patients with degenerative changes. comparison tissues differing metabolism, blood perfusion, or separateness from adjoining playing similar biomechanical role presenting some common morphological traits may shed new light on metabolism...
The study was carried out to determine the content of mercury in bone tissue proximal femur (head and neck bone) 95 patients undergoing total hip replacement due osteoarthritis, using CF-AFS analytical technique. Furthermore, investigations were aimed at assessing impact selected factors, such as age, gender, tobacco smoking, alcohol consumption, exposure chemical substance work, type degenerative changes, clinical evaluation radiological parameters, medications, on concentration head femur,...
Chronic non-bacterial osteomyelitis (CNO) has been known for over of 40 years. It is an underrecognized entity due to the low number described cases and poor propagation awareness problem. usually confused with infectious spondylodiscitis or malignant lesions, both primary metastatic. Failing consider CNO as one possible lesions spine among array differential diagnoses may lead a prolonged ineffective treatment increasing treatment-related morbidity. In this paper authors describe these two...
Although trace elements are regarded crucial and their content has been determined in number of tissue there only few papers addressing this problem intervertebral disc humans. Most the important substrates enzymes influencing metabolism senescence process. Others markers environmental pollution. Therefore aim research was to analyzed element disc, which may be a vital argument recognizing background degenerative changes effect environment or metabolic factors.Material consist 18 from 15...
Abstract Background Peutz-Jeghers syndrome (PJS) is a rare hereditary characterized by the occurrence of hamartomatous polyps in gastrointestinal tract, mucocutaneous pigmentation and increased risk cancer multiple internal organs. Depending on studied population, its incidence has been estimated to range from 1:200 000 even up 1:50 births. Being an autosomal disease, PJS caused most cases mutations STK11 gene. Methods The majority causative DNA changes identified patients with are small...
There is a growing body of evidence concerning the significant role silicon in development and composition both connective bone tissue. Bio-essential shows strong chemical biological affinity to aluminum, which toxic biologically inessential element. The presence was confirmed variety tissues; however, it has never been examined intervertebral disc tissue, neither healthy nor degenerated one. In this paper, for first time literature, we present content We also compared results analysis with...
Patient reported outcome measures play an increasingly important role in the outcomes research. The Core Outcome Measures Index (COMI) is a short, multidimensional instrument initially developed for use by patients with low back pain. This study evaluation of Polish version COMI adapted neck One hundred twenty-three complaining pain were enrolled. All them completed questionnaire booklet containing COMI-neck, Neck Disability and Likert-type questions regarding frequency medications...
Efficient and cost-effective screening for DNA sequence changes, both small mutations copy number variations (CNVs), is a crucial aspect routine genetic diagnostics as well basic research. In this study we present development evaluation of comparative-high resolution melting (C-HRM), new approach the simultaneous changes gene CNVs. contrast to other methods, relative quantification in C-HRM based on results obtained during process calculations peak height ratio multiplex reaction. Validation...
The work is designed to uncover the pattern of mutual relation among trace elements and epidemiological data in degenerated intervertebral disk tissue humans. Hitherto reason degenerative process not fully understood. Trace are basic components biological compound related both its metabolism as well environmental exposure. occurs gives new perspective solving cause disease.We have analysed content 30 disc from 22 patients with disease. concentrations Al, Cu, Cd, Mo, Ni Pb were determined...
The risk of disc herniation in the thoracic spine is much less common than cervical and lumbar segments. It occurs about 0.25 to 0.75% reported cases [1]. Osteoarthritis intervertebral most between 30 50 years age. Unlike case spine, classic anterior access spinal canal not possible due vascular structures thorax. A modified posterior approach similar procedures applied area used decompress discopathy i.e., a hernia located laterally. An important problem, however, hernias that compress cord...