A5006099132- Colorectal Cancer Treatments and Studies
- Cancer Research and Treatments
- Cell death mechanisms and regulation
- Immunotoxicology and immune responses
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Genomics and Diagnostics
- Genetic and phenotypic traits in livestock
- Gut microbiota and health
- Carcinogens and Genotoxicity Assessment
- Neonatal Respiratory Health Research
- Cancer Cells and Metastasis
- Effects of Radiation Exposure
- Food composition and properties
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- ATP Synthase and ATPases Research
- 3D Printing in Biomedical Research
- Birth, Development, and Health
- Lipid metabolism and disorders
- Pancreatic and Hepatic Oncology Research
- Pregnancy and preeclampsia studies
- RNA Interference and Gene Delivery
The Maria Sklodowska-Curie National Research Institute of Oncology
2011-2024
The evaluation of spontaneous lesions in classical inbred strains mice has become increasingly important because genetically engineered (GEMs) are created on these backgrounds. Novel strains-genetically diverse from classic strains-are valuable both as a new background for GEM and to increase the genetic variation found laboratory mice. Newly arising alterations commonly used may also lead mouse models disease. This report evaluates gross histological relatively new, classic, rarely explored...
Colorectal cancer (CRC) is the second most common in Europe and a leading cause of death worldwide. Patient-derived xenograft (PDX) models maintain complex intratumoral biology heterogeneity therefore remain platform choice for translational drug discovery. In this study, we implanted 37 primary CRC tumors five cell lines into NU/J mice to develop models. Primary established xenografts were histologically assessed surveyed genetic variants gene expression using panel 409 cancer-related genes...
Abstract The treatment of many aggressive cancers remains a significant unmet medical need. An aberrant dependence tumors on mitochondrial oxidative phosphorylation pathways has been well characterized in mediating the progression pancreatic cancers, as some other malignancies. However, discovery and development new therapeutic strategies targeting or manipulating this pathway relatively slow when compared with limiting current options for treating patients. One key technical challenge...
Background: The study investigated the impact of starch degradation products (SDexF) as prebiotics on obesity management in mice and overweight/obese children. Methods: A total 48 a normal diet (ND) Western (WD) were divided into subgroups with or without 5% SDexF supplementation for 28 weeks. In human study, 100 children randomly assigned to prebiotic control groups, consuming fruit vegetable mousse 10 g 24 Stool samples analyzed microbiota using 16S rRNA gene sequencing, short-chain fatty...
TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein capable of selectively inducing apoptosis in cancer cells by binding to its cognate receptors. Here, we examined the anticancer efficacy recently developed chimeric AD-O51.4 protein, TRAIL fused VEGFA-originating peptide. We tested activity against human colorectal (CRC) models and investigated resistance mechanism non-responsive CRC models. The quantitative comparison apoptotic between native nine cell lines...
The genetic basis of the peripheral blood cell parameters is not fully elucidated. Thus, it essential to research correlation between counts levels and genome in laboratory animals subsequently humans. In present study, we examined 288 F2 mice from a cross BALB/cW C57BL/6J-Mplhlb219/J. C57BL/6J-Mpl hlb219/J strain mouse model thrombocytopenia. We found very strong correlations for PLT revealed some highly significant RBC counts. On obtained results, presume that control erythrocyte divided...
SN-38, an active metabolite of irinotecan, exhibits toxicity to all proliferating cells, causing dose-limiting and potentially life-threatening side effects. Newly established water-soluble derivatives 7-ethyl-9-(N-morpholinyl)methyl-10-hydroxycamptothecin (BN-MOA) 7-ethyl-9-(N-methylamino)methyl-10-hydroxycamptothecin (BN-NMe), exhibit a unique mechanism spontaneous alkylation aromatic bases in DNA show greater vitro activity on cancer cell lines than SN-38. The aim this study was compare...