A5009467989- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Bee Products Chemical Analysis
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Agriculture, Plant Science, Crop Management
- Plant chemical constituents analysis
- Advanced Drug Delivery Systems
- Biochemical and biochemical processes
- Seaweed-derived Bioactive Compounds
- Flavonoids in Medical Research
- Inflammatory Bowel Disease
- Pharmacology and Nanomedicine Research
- Nanocomposite Films for Food Packaging
- Light effects on plants
- Salivary Gland Disorders and Functions
- Advancements in Transdermal Drug Delivery
- Wound Healing and Treatments
- Folate and B Vitamins Research
- Complementary and Alternative Medicine Studies
- Radioactivity and Radon Measurements
- Plant Pathogens and Fungal Diseases
- Natural Antidiabetic Agents Studies
- T-cell and B-cell Immunology
- Nanoparticles: synthesis and applications
Poznan University of Medical Sciences
2013-2024
Heliodor Swiecicki Clinical Hospital
2015-2021
Three species from the Eryngium L. genus—E. campestre, E. maritimum, and planum, plants with a rich chemical composition, were selected for phytochemical biological studies. The applied biotechnological methods allowed to obtain biomass of these rare or protected in form multiplied shoots (stationary system) roots cultured liquid medium (agitated system). In extracts raw material obtained under vitro conditions, content phenolic acids flavonoids (HPLC-DAD method) as well total polyphenols...
The objective of this study was to evaluate the usefulness a hydroalcoholic extract from Galinsoga parviflora herb (GP) in some aspects endothelial cell function necessary for anti-inflammatory activity and wound healing relate these GP phytochemical profile. This demonstrated that caused dose-dependent reduction IL-6 secretion on IL-1β-stimulated cells. release decreased 33% ± 9% while did not influence without stimulation. Additionally, exhibited an anti-hyaluronidase (IC50 = 0.47 mg/mL),...
Calendulae flos is a valued plant material with known anti-inflammatory and antimicrobiological properties. The limitation for its use in the treatment of chronic wounds lack adhesion to required site action. Obtaining lyophilized extract from water-ethanolic allowed prepare valuable whose biological activity wound healing process was confirmed by positive result scratch test. standardized contents chlorogenic acid narcissin. significant potency pharmacological has become reason studies on...
As a systemic disease, diabetes mellitus (DM) is characterized by the disruption of many glucose metabolic pathways. Therefore, it seems critical to study new therapies support treatment develop therapeutic systems that can operate across broad spectrum. The current state knowledge indicates an essential role gut microbiota in development and course disease. Cornus mas fruits have demonstrated rich biological activity profile potential for application DM. part preliminary analysis, four...
Chelidonium majus (also known as celandine) contains pharmacologically active compounds such isoquinoline alkaloids (e.g., chelidonine, sanguinarine), flavonoids, saponins, carotenoids, and organic acids. Due to the presence of alkaloids, Chelidonii herba extracts are widely used an antibacterial, antifungal, antiviral (including HSV-1 HIV-1), anti-inflammatory agent in treatment various diseases, while chitosan is a biocompatible biodegradable carrier with valuable properties for...
Scutellaria baicalensis root displays anti-inflammatory and antibacterial properties due to the presence of flavonoids, particularly baicalin, baicalein, wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary mixture S. radix lyophilized extract chitosan as novel approach for periodontal diseases treatment. Two types were employed in preliminary studies on mixtures with standardized Thermosensitive prepared poloxamer 407, alginate sodium, cellulose derivatives...
, as a flavone-rich source, exhibits antibacterial, antifungal, antioxidant, and anti-inflammatory activity. It may be used therapeutic agent to treat various diseases, including vaginal infections. In this study, six binary mixtures of chitosan with stable
The human leukocyte antigen (HLA) allele group HLA-DQA1*05 predisposes to ulcerative colitis (UC) and is associated with the development of antibodies against infliximab in patients inflammatory bowel disease (IBD). Therefore, we hypothesized that presence correlates characteristics pediatric IBD. Within a multi-center cohort Poland, phenotype at diagnosis worst flare was established status assessed enabling genotype-phenotype analyses. present 221 (55.1%) out 401 children IBD (UC n = 188,...
Summary Coltsfoot leaves (Farfarae folium) are used in the European medicine respiratory tract diseases, for cough, bronchitis and asthmatic disorders, while traditional Chinese only flower buds flos) have been recognized as a medicine. A short literature review shows that most data concern chemical composition of coltsfoot flowers. During carried out studies we isolated identified (UV, 1 H 13 C NMR, analysis acid enzymatic hydrolyze products) six known flavonols from leaves: kaempferol its...
Recently, cellular senescence has been of great interest due to its pleiotropic nature and association with both physiological (e.g., aging) pathological conditions. Excessive accumulation reactive oxygen species (ROS) can induce inflammation, which accelerates skin aging (also premature may cause several dermatoses. It postulated that plant-derived antioxidants, especially plant stem cells, prevent cell damage by preserving stemness reducing ROS targeting. Therefore, this paper aims review...
Hepcidin is a protein responsible for maintaining iron (Fe) homeostasis. Data regarding the role of hepcidin in pathomechanism Fe balance disturbances associated with acromegaly (AG) are scarce. The aim study was to assess impact alterations complete blood count parameters, homeostasis, gonadal status and GH/IGF-1 on level AG patients. evaluated differences concentration homeostasis between patients newly diagnosed comparison healthy control subjects (CS). We prospectively enrolled 25 adult...
Abstract This work initiates the original and updated literature review of current state research on Saniculoideae subfamily, emphasizing selected genera Saniculeae , namely Sanicula Hacquetia Astrantia, Eryngium . Various parts these plants, especially aerial roots, have an immense range medicinal uses in traditional medicine for a number ailments. Phytochemical studies conducted species indicate that plants synthesize metabolites belonging to diverse groups compounds. These include...
The article presents the actual knowledge of chemistry and pharmacological activity fumitory (Fumaria officinalis L.). genus Fumaria (latin fumus – smoke) includes about 55 species annual plants, occuring in Asia, North Africa, Europe. In Poland, F. overgrows fields, wastelands, roadsides, gardens. Fumariae herba contains numerous isoquinoline indenobenzazepine alkaloids, flavonoids (derivatives quercetin kaempferol), organic acids mineral salts. results research, including clinical trials,...
In recent years, natural antioxidants are often investigate because of synthetic have an adverse effect on human health. Scientific research in the food industry focused search for that would be similarly effective to antioxidants. For this purpose, commonly known and used compounds (e.g. carotenoids), spices herbs particularly rich chemical with strong antioxidant properties rosemary, thyme, sage, oregano, garlic, cloves) as well green tea extracts, fruit extracts plums, apricots,...
Introduction. Mother of thousands (Kalanchoe daigremontiana) in folk medicine is applied the form compresses fresh, crushed leaf, or juice leaves inflammation skin, burns and wound healing. Aim. The aim study was to compare anti-inflammatory antioxidant properties juices obtained from K. daigremontiana, as well determine content polyphenols flavonoids. Material methods. Compared anti-hyaluronidase activity potential (DPPH FRAP) daigremontiana using a spectrophotometric Moreover, total...