A5056067126- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Phytochemicals and Antioxidant Activities
- Electrospun Nanofibers in Biomedical Applications
- Bee Products Chemical Analysis
- Antibiotic Resistance in Bacteria
- Sirtuins and Resveratrol in Medicine
- Oral microbiology and periodontitis research
- Advancements in Transdermal Drug Delivery
- Nanocomposite Films for Food Packaging
- Medicinal Plants and Neuroprotection
- Natural Antidiabetic Agents Studies
- Lichen and fungal ecology
- Phytochemicals and Medicinal Plants
- Phenothiazines and Benzothiazines Synthesis and Activities
- Wound Healing and Treatments
- Pomegranate: compositions and health benefits
- Pesticide Residue Analysis and Safety
- Essential Oils and Antimicrobial Activity
- Botany and Plant Ecology Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Natural product bioactivities and synthesis
Poznan University of Medical Sciences
2015-2025
Heliodor Swiecicki Clinical Hospital
2018-2021
The plant material Scutellariae baicalensis radix, which is rich in flavones (baicalin), possesses antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This work aimed to develop a 3D-printed chitosan-based hydrogel extract as an innovative approach for the personalized treatment of periodontal diseases. Chitosan-based hydrogels were prepared, printability prepared was determined. with 2.5% w/v high molecular-weight chitosan (CS), 2% gelatin (Gel), 10% w/w (Ex) presented...
Blackberry fruits are recognized as functional foods while blackberry leaves outside this classification and they also contain active compounds with health-promoting potential. Therefore, the aim of study was phytochemical analysis varieties (Chester, Loch Ness, Tay Ruczaj) screening their biological activity (antioxidant potential, possibility inhibition enzymes, anti-inflammatory microbial activity). The following from selected groups: phenolic acids (caffeic acid, ellagic gallic syringic...
Orange peel, which is a rich source of polyphenolic compounds, including hesperidin, produced as waste in production. Therefore, optimization the extraction hesperidin was performed to obtain its highest content. The influence process parameters such kind mixture, temperature and number repetitions cycles on content, total content phenolic compounds antioxidant (DPPH scavenging assay) well anti-inflammation activities (inhibition hyaluronidase activity) checked. Methanol were key determining...
Pomegranate peel extract is known for its potent antibacterial, antiviral, antioxidant, anti-inflammatory, wound healing, and probiotic properties, leading to use in treating oral infections. In the first stage of this work, time, using Design Experiment (DoE) approach, pomegranate (70% methanol, temperature 70 °C, three cycles per 90 min) was optimized obtained, which showed optimal antioxidant anti-inflammatory properties. The antibacterial activity against pathogenic bacteria. second part...
This study aimed to obtain and characterize an RU-β-CD complex in the context of investigating possibility changes solubility, stability, antioxidative microbiological activity as well permeability complexated rutin against its free form. The formation via a co-grinding technique was confirmed by using DSC, SEM, FT-IR Raman spectroscopy, geometry assessed through molecular modeling. It found that stability solubility so-obtained were greater compared form; however, slight decrease observed...
Despite the wide pharmacological action of polyphenols, their usefulness is limited due to low oral bioavailability, which solubility and rapid first-pass metabolism. Red vine leaf extract an herbal medicine containing several with resveratrol polydatin as main compounds exhibiting antioxidant anti-inflammatory properties. In first stage work, using Design Experiment (DoE) approach, red (50% methanol, temperature 70 °C, three cycles per 60 min) was obtained, showed optimal order circumvent...
Centella asiatica extract is a valued plant material with known anti-inflammatory and anti-microbiological properties. Using the Design of Experiment (DoE) approach, it was possible to obtain an optimized water/alcoholic from asiatica, which allowed preparation final biological activity in wound healing process. Studies on novel applications conjunction multifunctional chitosan carrier have been motivated by plant's substantial pharmacological need develop new effective methods for treatment...
Photoaging is a process related to an increased level of reactive oxygen species (ROS). Polyphenols can scavenge free radicals in the body, which delay skin aging. Therefore, our work aimed prepare biologically active extract from dry fruits Vaccinium myrtillus or corymbosum and use it for preparation hydrogels topical application. eight different extracts (using V. extraction mixtures: methanol, methanol–water 1:1, water, acetone–water 1:1) were prepared their phytochemical (total...
Sambuci folium (elderberry leaves) have been used in traditional medicine, mainly externally, to treat skin diseases and wounds. Therefore, the aim of this study was screen biological activity elderberry leaves (antioxidant potential possibility inhibition tyrosinase hyaluronidase enzymes) combined with phytochemical analysis. For purpose, a analysis carried out. Elderberry 12 varieties (“Sampo”, “Obelisk”, “Dwubarwny”, “Haschberg”, “Haschberg 1”, “Koralowy”, “Sambo”, “Black Beauty”, Tower”,...
Background/Objectives: This study explores the development of electrospun nanofibers incorporating bioactive compounds from Withania somnifera (Ashwagandha) root extract, focusing on optimizing extraction conditions and nanofiber composition to maximize biological activity application potential. Methods: Using Design Experiment (DoE) approach, optimal parameters were identified as 80% methanol, 70 °C, 60 min, yielding high levels phenolic antioxidant activity. Methanol concentration emerged...
Background: Azithromycin (AZC), a BCS class II/IV antibiotic with broad-spectrum antimicrobial activity, has poor water solubility, limiting its formulation potential. This study aimed to develop and optimize AZC-based soft hydrogels for the first time improved local controlled drug release, dental applications. Methods: AZC nanoparticles (based on polyvinylpyrrolidone) were synthesized via electrospinning enhanced solubility 40-fold. These incorporated into chitosan (CS) varying...
The aim of the study was to establish influence chitosan on preparation systems containing Scutellariae baicalensis radix extract and demonstrate potential anti-inflammatory action for treatment periodontitis. In first stage, impact variables (extraction mixture composition, temperature, number extraction cycles) extracted samples’ biological characteristics analyzed using Design Experiments (DoE) approach. best conditions baicalin, baicalein, wogonin from were 80% methanol in mixture, 70...
Marigold flower is a traditionally used plant material topically applied on the skin due to its anti-inflammatory properties and antibacterial activity. This potential of action justifies implementation marigold extract in nanofiber scaffolds based poly-vinylpyrrolidone/hydroxypropyl-β-cyclodextrin (PVP/HPβCD) polycaprolactone/polyvinylpyrrolidone (PCL/PVP) obtained by electrospinning for wound treatment. Using SEM, morphology electrospun showed fiber diameter range 298-527 nm, with uniform...
B-Lactam antibiotics are still the most common group of chemotherapeutic drugs that used in treatment bacterial infections. However, due to their chemical instability potential apply them as oral pharmacotherapeutics is often limited and so it vital employ suitable non-destructive analytical methods. Hence, order analyze such labile β-lactam analogs, application rapid reliable techniques which do not require transferring solutions or using organic solvents, following current green approach...
A novel approach for drug design based on the oral carbapenem analog tebipenem pivoxil (TP) has been proposed. The formation of pivoxil-β-cyclodextrin (TP-β-CD) complex resulted in changes concerning physicochemical properties TP, which is significant planning development an innovative pharmaceutical formulation as well modifications biological activity profile studied delivery system. inclusion TP into β-cyclodextrin (β-CD) was confirmed by spectral (infrared and Raman spectroscopies)...
Calendulae flos is a valued plant material with known anti-inflammatory and antimicrobiological properties. The limitation for its use in the treatment of chronic wounds lack adhesion to required site action. Obtaining lyophilized extract from water-ethanolic allowed prepare valuable whose biological activity wound healing process was confirmed by positive result scratch test. standardized contents chlorogenic acid narcissin. significant potency pharmacological has become reason studies on...
The health benefits of resveratrol have been proven to inhibit the development numerous diseases. A frequent limitation in its use is a low bioavailability stemming from poor solubility and fast enterohepatic metabolism. Thus, aim research was investigate possibility formulate mucoadhesive cyclodextrin- xanthan gum-based buccal tablets order increase eliminate bypass Systems with α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) 2-hydroxypropyl-β-cyclodextrin (HP-β-CD)...
Chitosan is a valued excipient due to its biocompatibility properties and increasing solubility of poorly water-soluble drugs. The research presented in this paper concerns the preparation binary combinations chitosan (deacetylated chitin) with carvedilol (beta-blocker) develop formulation modified release profile. As part research, six physical mixtures were obtained identified by spectral (PXRD, FT-IR, Raman), thermal (DSC), microscopic (SEM) methods. next stage estimated profile changes...