A5027086260- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Porphyrin and Phthalocyanine Chemistry
- Pharmacological Effects of Natural Compounds
- Photodynamic Therapy Research Studies
- Crystal structures of chemical compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Luminescence and Fluorescent Materials
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Metal-Catalyzed Oxygenation Mechanisms
- Magnetism in coordination complexes
- Photochemistry and Electron Transfer Studies
- Nanoplatforms for cancer theranostics
- Synthesis and Reactions of Organic Compounds
- Drug Solubulity and Delivery Systems
- Plant biochemistry and biosynthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Medicinal Plants and Neuroprotection
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Photocatalysis Techniques
- Chromatography in Natural Products
- TiO2 Photocatalysis and Solar Cells
- Chemical Synthesis and Analysis
Poznan University of Medical Sciences
2016-2025
Adam Mickiewicz University in Poznań
1991-2003
University of South Carolina
1986-1990
Three 2-(morpholin-4-yl)ethoxy substituted phthalocyanines were synthesized and characterized. Phthalocyanine derivatives revealed moderate to high quantum yields of singlet oxygen production depending on the solvent applied (e.g., in DMF ranging from 0.25 0.53). Their photosensitizing potential for photodynamic therapy was investigated an vitro model using cancer cell lines. Biological test results found particularly encouraging zinc(II) phthalocyanine derivative possessing two substituents...
This study aimed at obtaining hesperidin (Hed) and hesperetin (Het) systems with HP-β-CD by means of the solvent evaporation method. The produced were identified using infrared spectroscopy (FT-IR), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC). Moreover, in silico docking molecular dynamics studies performed to assess most preferable site interactions between tested compounds HP-β-CD. changes physicochemical properties (solubility, dissolution rate, permeability)...
The objective of this study was to obtain co-amorphous systems poorly soluble sinapic acid using amino acids as co-formers. In order assess the probability interaction acids, namely, arginine, histidine, lysine, tryptophan, and proline, selected co-formers in amorphization acid, silico studies were carried out. Sinapic with a molar ratio 1:1 1:2 obtained ball milling, solvent evaporation, freeze drying techniques. X-ray powder diffraction results confirmed loss crystallinity regardless...
In this study, amorphous solid dispersions (ASDs) of pterostilbene (PTR) with polyvinylpyrrolidone polymers (PVP K30 and VA64) were prepared through milling, affirming the dispersion PTR via X-ray powder diffraction (XRPD) differential scanning calorimetry (DSC). Subsequent analysis DSC thermograms, augmented using mathematical equations such as Gordon–Taylor Couchman–Karasz equations, facilitated determination predicted values for glass transition (Tg), PTR’s miscibility PVP, strength...
Apigenin (APG), a bioactive flavonoid with promising therapeutic potential, suffers from poor water solubility, which limits its bioavailability. To address this, solid dispersions of APG were prepared using ball milling sodium alginate (SA), Pluronic® F-68 (PLU68), F-127 (PLU127), PVP K30, and VA64 as polymeric excipients. These screened for apparent solubility in buffers pH 1.2, 5.5, 6.8. Based on improved after 60 min, APG-PLU68 APG-PLU127 selected further study. DSC FT-IR analysis...
Abstract Cancer remains one of the most significant health issues worldwide. By designing compounds with anticancer activity characterized by high selectivity towards cancer cells, medicinal chemistry focuses on protection healthy cells and tissues. In this study, we present hybrid pharmacophore approach, which afforded a series new pyrrole flavones. The synthetic strategy was based Paal-Knorr synthesis, starting from aminoflavones through their condensation 1,4-diketones leading to 6-...
The nutraceutical system of curcumin-piperine in 2-hydroxypropyl-β-cyclodextrin was prepared by using the kneading technique. Interactions between components were defined X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR). Application hydroxypropyl-β-cyclodextrin as a carrier-solubiliser improved solubility system, its permeability through biological membranes (gastrointestinal tract, blood-brain barrier)...
The present study reports amorphous solid dispersions (ASDs) of hesperidin (Hes) prepared by ball milling to improve its solubility and apparent over the unmodified compound. carriers were Soluplus® (Sol), alginate sodium (SA), hydroxypropylmethylcellulose (HPMC). XRPD analysis confirmed full amorphization all binary systems in 1:5 w/w ratio. One glass transition (Tg) observed DSC thermograms hesperidin:Soluplus® (Hes:Sol) hesperidin:HPMC (Hes:HPMC) complete miscibility. mathematical model...
The aim of our research was to improve the solubility and antioxidant activity pterostilbene (PTR) by developing a novel amorphous solid dispersion (ASD) with Soluplus® (SOL). DSC analysis mathematical models were used select three appropriate PTR SOL weight ratios. amorphization process carried out low-cost green approach involving dry milling. An XRPD confirmed full systems in 1:2 1:5 One glass transition (Tg) observed thermograms complete miscibility systems. indicated strong...
Poor bioavailability hampers the use of curcumin and piperine as biologically active agents. It can be improved by enhancing solubility well using bioenhancers to inhibit metabolic transformation processes. Obtaining an amorphous system lead overcoming these limitations. Hot-melt extrusion successfully produced their systems, shown XRPD DSC analyses. Additionally, presence intermolecular interactions between components systems was investigated FT-IR/ATR technique. The were able produce a...
In this study, binary amorphous solid dispersions (ASDs, fisetin-Eudragit®) and ternary inclusions (ASIs, fisetin-Eudragit®-HP-β-cyclodextrin) of fisetin (FIS) were prepared by the mechanochemical method without solvent. The nature FIS in ASDs ASIs was confirmed using XRPD (X-ray powder diffraction). DSC (Differential scanning calorimetry) full miscibility multicomponent delivery systems. FT-IR (Fourier-transform infrared analysis) interactions that stabilize FIS's state identified...
The first structural characterization of glycyrrhizic acid, its monoammonium salt (AGA), and the complex with p-aminobenzoic acid in solid state is reported. X-ray crystallography reveals that neutral ionic forms GA have similar supramolecular organization, aglycon groups protruding from 2D hydrogen-bonded sugar platform. Interpenetration these assemblies leads to generation intersecting channels where solvent guest molecules are enclosed. It worth noting small or cations can functionally...
Rosmarinic acid (RA) is a natural antioxidant with neuroprotective properties; however, its preventive and therapeutic use limited due to slight solubility poor permeability. This study aimed improve RA physicochemical properties by systems formation cyclodextrins (CDs): hydroxypropyl-α-CD (HP-α-CD), HP-β-CD, HP-γ-CD, which were prepared the solvent evaporation (s.e.) method. The interactions between components determined X-ray powder diffraction (XRPD), differential scanning calorimetry...
Our research aimed to develop an amorphous solid dispersion (ASD) of myricetin (MYR) with Polyvinylpyrrolidone K30 (PVP30) enhance its solubility, dissolution rate, antioxidant, and neuroprotective properties. Employing a combination solvent evaporation freeze drying, we successfully formed MYR ASDs. XRPD analysis confirmed complete amorphization in 1:8 1:9 MYR-PVP weight ratios. DSC thermograms exhibited single glass transition (Tg), indicating full miscibility. FT-IR results molecular...
The health benefits of resveratrol have been proven to inhibit the development numerous diseases. A frequent limitation in its use is a low bioavailability stemming from poor solubility and fast enterohepatic metabolism. Thus, aim research was investigate possibility formulate mucoadhesive cyclodextrin- xanthan gum-based buccal tablets order increase eliminate bypass Systems with α-cyclodextrin (α-CD), β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD) 2-hydroxypropyl-β-cyclodextrin (HP-β-CD)...
Attenuated total reflection-Mid-Fourier transform-infrared (ATR-Mid-FT-IR) spectroscopy combined with principal component analysis (PCA) has been applied for the discrimination of amorphous solid dispersion (ASD) kaempferol different types Eudragit (L100, L100-55, EPO). The ASD samples were prepared by ball milling. Training and test sets PCA consisted a pure compound, physical mixture, incomplete/complete dispersion. obtained results confirmed that range 400–1700 cm−1 was major contributor...
This study aimed to investigate changes in the solubility and antimicrobial efficacy of cefuroxime axetil (CA) when incorporated into cyclodextrin (CD). While choosing CD, validated silico model was used. A theoretical based on docking molecular mechanics/generalized born surface area using a curated dataset API (active pharmaceutical ingredient)-CD stability constants. The library commonly used cyclodextrins virtually screened, indicating CA -hydroxypropyl-βCD (HPβCD) as most...
Progressive increase in bacterial resistance has caused an urgent need to introduce new antibiotics, one of them being oxazolidinones with their representative tedizolid. Despite the broad spectrum activity parent tedizolid, it is characterized by low water solubility, which limits its use. The combination active molecule a multifunctional excipient, cyclodextrins, allows preservation pharmacological and modification physicochemical properties. Therefore, aim study was change dissolution...