A5065681889- Hepatitis C virus research
- Immune Cell Function and Interaction
- Sirtuins and Resveratrol in Medicine
- Immune cells in cancer
- Nanoparticles: synthesis and applications
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Bone Tissue Engineering Materials
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Titanium Alloys Microstructure and Properties
- Natural product bioactivities and synthesis
- Inflammation biomarkers and pathways
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Mesenchymal stem cell research
- Bipolar Disorder and Treatment
- Genomics, phytochemicals, and oxidative stress
- Advanced biosensing and bioanalysis techniques
- Immunotherapy and Immune Responses
- Pleural and Pulmonary Diseases
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Synthesis and biological activity
- Sinusitis and nasal conditions
Poznan University of Medical Sciences
2016-2025
Greater Poland Cancer Center
2020-2025
Gdańsk University of Technology
2024
Weatherford College
2022
Frederick National Laboratory for Cancer Research
2008
National Cancer Institute
2008
University of Łódź
2004-2005
Lodz University of Technology
2004-2005
Materials Science & Engineering
2004
The basic goal of this study was to synthesize zinc oxide nanoparticles using the Chelidonium majus extract and asses their cytotoxic antimicrobial properties. synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission (TEM) Atomic Force (AFM). aforementioned methods confirmed that size at range 10 nm. activity Ch. tested against standard strains bacteria...
Three 2-(morpholin-4-yl)ethoxy substituted phthalocyanines were synthesized and characterized. Phthalocyanine derivatives revealed moderate to high quantum yields of singlet oxygen production depending on the solvent applied (e.g., in DMF ranging from 0.25 0.53). Their photosensitizing potential for photodynamic therapy was investigated an vitro model using cancer cell lines. Biological test results found particularly encouraging zinc(II) phthalocyanine derivative possessing two substituents...
The specific characteristics of endometriotic cells are their ability to evade the apoptotic machinery and abnormal response stimuli. Natural-originated compounds may constitute a beneficial strategy in apoptosis modulation endometriosis. We investigated compared potency natural resveratrol analogs, including piceatannol, polydatin, pterostilbene, targeting cell death pathways, apoptosis-related morphologic biochemical processes, alongside critical genes expression. Upon pterostilbene...
Abstract Research has shown that the microbiome can influence how immune system responds to melanoma cells, affecting course of disease and outcome therapy. Here, we used metagenomic approach flow cytometry analyses blood cells discover correlations between gut fungi metastatic patients enrolled in anti-PD-1 therapy lymphocytes their blood. We analyzed patterns associations before first administration (BT, n = 61) third month (T3, 37), allowing us track changes during treatment. To...
Due to the search for new methods of producing bimetallic nanoparticles, in this work, we have conducted a biological synthesis Au-CuO and CuO-ZnO nanoparticles using Cnici benedicti. The synthesized were also analyzed terms their antibacterial activity, as well influence on cell viability, two specific lines: C6 rat brain glioma (ATCC® CCL-107™) T98G human CRL-1690™). studies carried out by means Atomic Force Microscopy helped determine presence whose size was about 13 nm. 28 obtained...
Due to the search for new methods synthesizing nanomaterials, this work proposes biological synthesis of platinum nanoparticles using Ononidis radix extract. The synthesized were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier transform infrared spectroscopy (FTIR), Transmission (TEM) and Atomic Force (AFM). examination conducted means showed presence spherical hexagonal nanoparticles. indicated locally agglomerated whose size was about 4 nm. study also...
Human telomeres were one of the first discovered and characterized sequences forming quadruplex structures. Association these structures with oncogenic tumor suppressor proteins suggests their important role in cancer development therapy efficacy. Since cationic porphyrin TMPyP4 is known as G-quadruplex stabilizer telomerase inhibitor, aim study was to analyze anticancer properties this compound two different human breast-cancer MCF7 MDA-MB-231 cell lines. The cytotoxicity alone or...
Myeloid-derived suppressor cells (MDSC) are a subset of immature myeloid with suppressive activity well described in the context cancer. They inhibit anti-tumour immunity, promote metastasis formation and can lead to immune therapy resistance. In retrospective study, blood probes 46 advanced melanoma patients were analysed before first administration anti-PD-1 immunotherapy third month treatment for MDSC, monocytic (ImMC), MDSC (MoMDSC) granulocytic (GrMDSC) by multi-channel flow cytometry....
So far, a protective influence of phytosterols on the human organism and atherogenesis has been suggested. Most studies have concentrated cytotoxic efficacy cancer cells. However, there are only few reports showing their normal The aim present study was to determine whether dietary plant sterols thermal processing products could viability normal, abdominal endothelial cells that play crucial role in atherogenesis. Thus, we studied effect rapeseed oil-extract components, beta-sitosterol,...
Hypoxia-inducible factor (HIF-1) regulates the expression of genes that facilitate tumor cell survival by making them more resistant to therapeutic intervention. Recent evidence suggests activation other transcription factors, in cooperation with HIF-1 or acting alone, is involved upregulation hypoxia-inducible genes. Here we report high density, a condition might mimic physiologic situation growing and most probably representing nutritional starvation, upregulates This can occur...
In the present work, we report biosynthesis of Au nanoparticles using fruit extract Ribes nigrum. First, synthesis gold was performed, and then structural characteristics, antimicrobial activity cytotoxicity were assessed. The properties biosynthesized characterized by UV–Vis spectroscopy, Atomic Force Microscopy (AFM) measurements, Scanning Electron (SEM), Transmission (TEM) Fourier Transform Infrared Spectroscopy (FTIR). synthesized tested against standard clinical strains bacteria...
Photobiomodulation (PBM), also called low-level laser treatment (LLLT), has been considered a promising tool in periodontal due to its anti-inflammatory and wound healing properties. However, photobiomodulation’s effectiveness depends on combination of parameters, such as energy density, the duration frequency irradiation sessions, wavelength, which shown play key role laser-tissue interaction. The objective study was compare vitro effects two different wavelengths—635 nm 808 nm—on human...
Macrophages are among the infiltrate components of most malignant tumors. Tumor-associated macrophages (TAMs) may secrete a variety humoral factors, which promote or inhibit tumor growth. In general, depending on their activation pathway, exhibit two different patterns phenotype, M1 M2. It is assumed that TAMs comprise pattern pleural effusion, frequent component cytological evaluation. this microenvironment, could be involved in development immunity. The phenotype represented and...
Abstract In screening studies, the cytotoxic activity of four metabolites resveratrol analogue 3,4,5,4′-tetramethoxystilbene (DMU-212) against A-2780 and SKOV-3 ovarian cancer cells was investigated. The most active metabolite, 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214), chosen for further studies. cytotoxicity DMU-214 shown to be higher than that parent compound, DMU-212, in both cell lines tested. Since DMU-212 supposed undergo metabolic activation through its conversion DMU-214,...