A5023091967- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Immune cells in cancer
- Inflammation biomarkers and pathways
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Occupational and environmental lung diseases
- Pituitary Gland Disorders and Treatments
- Airway Management and Intubation Techniques
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Pulmonary Hypertension Research and Treatments
- Iron Metabolism and Disorders
- Cardiac Imaging and Diagnostics
- Immune Response and Inflammation
- Systemic Sclerosis and Related Diseases
- Pleural and Pulmonary Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Childhood Cancer Survivors' Quality of Life
Poznan University of Medical Sciences
2011-2024
Weatherford College
2022
Centrum Onkologii
2019
Abstract Background Patients with idiopathic pulmonary fibrosis (IPF) frequently have multiple comorbidities, which may influence survival but go under-recognised in clinical practice. We therefore report comorbidity, antifibrotic treatment use and of patients IPF observed the multi-national EMPIRE registry. Methods For this prospective cohort, demographics, causes death were analysed. Comorbidities noted by treating physician based on patient’s past medical history or as reported during...
Macrophages are among the infiltrate components of most malignant tumors. Tumor-associated macrophages (TAMs) may secrete a variety humoral factors, which promote or inhibit tumor growth. In general, depending on their activation pathway, exhibit two different patterns phenotype, M1 M2. It is assumed that TAMs comprise pattern pleural effusion, frequent component cytological evaluation. this microenvironment, could be involved in development immunity. The phenotype represented and...
Fat-soluble vitamin deficiency remains a challenge in cystic fibrosis (CF), chronic pancreatitis, and biliary atresia. Liposomes cyclodextrins can enhance their bioavailability, thus this multi-center randomized placebo-controlled trial compared three-month supplementation of fat-soluble vitamins the form liposomes or to medium-chain triglycerides (MCT) pancreatic-insufficient CF patients. The daily doses were as follows: 2000 IU retinyl palmitate, 4000 D3, 200 RRR-α-tocopherol, µg K2...
Damage-associated molecular pattern (DAMP) molecules can initiate an immune response through Toll-like receptors (TLRs). DAMPs are released from cells as a to the extracellular danger and be by-products of tissue damage. In cancer microenvironment necrotic release debris which has potency become DAMPs. Non-small cell lung (NSCLC) is often accompanied by pleural effusion (PE), contains variety Surfactant protein A (SP-A) heat shock 70 (Hsp70) important in respiratory tract. The aim this study...
As life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of disease. We aimed to: compare their concentrations clinically stable CF patients and healthy subjects (HS) verify whether they independently correlate with characteristics. Serum sVCAM-1 sP-selectin levels were measured using ELISA. was characterized using:...
Introduction: Bronchial artery embolisation (BAE) is one of the methods used in massive and recurring haemoptysis. The aim study to determine effectiveness complications bronchial Material methods: analysis included 47 procedures performed on 30 patients treated between 2011 2017 Department Respiratory Medicine, Allergology Pulmonary Oncology due patient’s age ranged 18 71 years, while mean at time BAE was 33.5 years. Patients with tuberculosis constituted 73.33% (n = 22) sample underwent 31...
Myeloid-derived suppressor cells (MDSCs) are present in the human lung microenvironment, and they may be involved local inflammatory process chronic obstructive pulmonary disease (COPD). Chronic inflammation COPD induce immunogenic cell death of structural airway cells, causing release damage-associated molecular patterns (DAMPs). DAMPs activate innate adaptive immune system. The relationship between MDSCs is poorly described available literature. Objectives. (1) Assessment MDSC percentage...
INTRODUCTION Myeloid‑derived suppressor cells (MDSCs) have the potent ability to suppress T‑cell function, and are important in regulation of chronic inflammation carcinogenesis. MDSCs may influence local systemic carcinogenesis COPD; however, their presence bronchoalveolar lavage fluid (BALF) peripheral blood (PB) or relationship with clinical parameters COPD has not been studied yet. OBJECTIVES The aim study was assess BALF PB analyze between COPD. PATIENTS AND METHODS included 64 patients...
Background & Aims: Although indirect methods of assessment the exocrine pancreatic function have become standard care in monitoring status, it still remains a current clinical challenge. Our aim was to compare width duct insufficient (PI) and sufficient (PS) cystic fibrosis (CF) patients using secretin-enhanced magnetic resonance cholangiopancreatography (SE-MRCP).
 Methods: Thirty-seven CF were enrolled for this cross-sectional study, including 21 PI 16 PS, all whom underwent...
Nintedanib is a disease-modifying agent licensed for the treatment of IPF. Data on Polish experience with nintedanib in IPF are lacking. The present study aimed to describe safety and efficacy profiles large real-world cohort patients This was multicenter, retrospective, observational treated between March 2018 October 2021. collection included baseline clinical characteristics, results pulmonary function tests (PFTs), six-minute walk test (6MWT). Longitudinal data PFTs, 6MWT, adverse drug...
In recent years, questionnaires were published in English to assess the quality of life patients with PCD (Primary Ciliary Diskinesia) for adults, adolescents aged 13–17 and children 6–12 years their caregivers. This study aimed prepare Polish versions validate them specific age groups participation PCD. The individual translated discussed involvement creator original questionnaire English. Patients completed according affiliation one groups. Validation was based on internal consistency...
Macrophages in malignant pleural effusions (MPEs) demonstrate a promalignant phenotype. They release mediators, which are source of inflammation within the pleura. We established vitro model proving that macrophages isolated from affect cancer cells their pro- or anti-apoptotic activity via humoral mediators. Additionally, we measured concentrations selected transcription factors cells. Pleural can apoptosis intercellular mediators trigger different signal transductors The observed effect is...
A case of lung adenocarcinoma with metastases in both adrenals and pituitary gland 52-year old patient is presented. Adrenal glands were diagnosed on a base CT scans. Pituitary caused gradual loss vision. MR imaging showed lesion the sella suprasellar areas sugested meningioma. Right frontal craniotomy partial removal tumor was performed. Three days later died. Histopathological results masses revealed adenocarcinoma.