A5041020752- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Studies on Chitinases and Chitosanases
- Sarcoidosis and Beryllium Toxicity Research
- Neonatal Respiratory Health Research
- Obstructive Sleep Apnea Research
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Pulmonary Hypertension Research and Treatments
- Eosinophilic Esophagitis
- Lung Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Lung Cancer Treatments and Mutations
- Parasites and Host Interactions
- Congenital Diaphragmatic Hernia Studies
- Vascular Malformations and Hemangiomas
- Systemic Sclerosis and Related Diseases
- Occupational exposure and asthma
- Dermatology and Skin Diseases
Medical University of Warsaw
2016-2025
Poznan University of Medical Sciences
2024
The Maria Sklodowska-Curie National Research Institute of Oncology
2020-2021
Centrum Onkologii
2020
Medical University of Lodz
2019
Wroclaw University of Economics and Business
2018
École Polytechnique Fédérale de Lausanne
2013-2015
NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry
2013
Although eosinophilic pleural effusion (EPE) has been a subject of numerous studies, its clinical significance still remains unclear. The aim our study was to evaluate: 1) the relative incidence and aetiology EPE; 2) predictors malignancy in patients with 3) relationship between repeated thoracentesis fluid eosinophilia. A retrospective analysis 2,205 samples from 1,868 treated 1995 2007 performed. We identified 135 EPE (7.2% all effusion) 153 samples. most common condition associated...
The introduction of sulfa drugs for the chemotherapy bacterial infections in 1935 revolutionized medicine. Although their mechanism action is understood, molecular bases most side effects remain obscure. Here, we report that sulfamethoxazole and other interfere with tetrahydrobiopterin biosynthesis through inhibition sepiapterin reductase. Crystal structures reductase bound reveal how structurally diverse achieve specific enzyme. effect on tetrahydrobiopterin-dependent neurotransmitter...
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with different inflammatory phenotypes. Various mediators play a role in these diseases. The aim of this study was to analyze the neutrophilic eosinophilic airway systemic inflammation as phenotypic characterization patients asthma COPD. Twenty-four 33 COPD were enrolled study. All mild-to-moderate stage disease, none them treated inhaled corticosteroids. Concentrations IL-6, neutrophil elastase (NE), matrix...
Abstract Background Patients with idiopathic pulmonary fibrosis (IPF) frequently have multiple comorbidities, which may influence survival but go under-recognised in clinical practice. We therefore report comorbidity, antifibrotic treatment use and of patients IPF observed the multi-national EMPIRE registry. Methods For this prospective cohort, demographics, causes death were analysed. Comorbidities noted by treating physician based on patient’s past medical history or as reported during...
Idiopathic pulmonary fibrosis (IPF) is a progressive and eventually fatal lung disease with complex etiology. Approved drugs, nintedanib pirfenidone, modify progression, but IPF remains incurable there an urgent need for new therapies. We identified chitotriosidase (CHIT1) as driver of in novel therapeutic target. demonstrate that CHIT1 activity expression are significantly increased serum (3-fold) induced sputum (4-fold) from patients. In the lungs expressed distinct subpopulation...
Abstract Cancers present a significant medical problem despite the development of and pharmaceutical sciences leading to search for further therapeutic approaches. One such approach could involve use curcumin or its derivatives. Curcumin reveals interesting antineoplastic effects that help in treatment cancer diseases. However, this natural product possesses some limitations which prevent application medicine. Among limitations, it is characterized by poor water solubility, low stability,...
<h3>BACKGROUND:</h3> Airway remodeling in asthma and COPD results bronchial wall thickening. The thickness of the can be measured high-resolution computed tomography. objectives study were to assess lumen dimensions patients, relation disease severity, compare airway patients with COPD. <h3>METHODS:</h3> Ten subjects 12 stable, mild moderate investigated. All underwent chest tomography (window level − 450 Hounsfield units, window width 1,500 units). Cross-sections bronchi (external diameter...
IL-6 and IL-33 are involved in the inflammatory process obstructive lung diseases. In contrast to IL-6, few data on expression of different biological samples from asthma COPD patients available. The aim was evaluate expressions bronchial mucosa compare these with concentrations both cytokines various respiratory mild-to-moderate COPD. Serum, induced sputum exhaled breath condensate levels, as well their were evaluated 22 33 patients. There significant differences between but not Serum IS...
IntroductIon Asthma is a chronic inflammatory disease with complex immunological background.Eosinophils are the main cells involved in asthma-related airway inflammation; however, there also significant contribution of neutrophils, lymphocytes, and mast cells.As type inflammation has been shown to affect treatment response, determination asthma phenotypes based on predominant strongly advocated.
Abstract Urban particulate matter (UPM) is an important trigger of airway inflammation. The cross-talk between the external and internal matrix in respiratory tract occurs due to transepithelial network macrophages/dendritic cells. This study characterized immune processes induced by epithelium after UPM exposure special regard interactions with monocyte-derived dendritic cells (moDCs) macrophages (moMφs) obstructive lung diseases. A triple-cell co-culture model (8 controls, 10 asthma, 8...
Pathobiology of asthma and chronic obstructive pulmonary disease (COPD) is associated with changes among respiratory epithelium structure function. Increased levels PM2.5 from urban particulate matter (UPM) are correlated enlarged rate COPD morbidity as well acute exacerbation. It has been suggested that pre-existing diseases predispose for different biological response than in healthy airways. The aim this study was to assess the impact on using 3D/spheroid culture model. spheroids 5...
In the respiratory system macrophages and dendritic cells collaborate as sentinels against foreign particulate antigens. The study used a triple-cell co-culture model, utilizing nasal epithelial cells, along with: monocyte derived (moMφs), DCs (moDCs). Cell cultures from 15 controls, 14 asthma 11 COPD patients were stimulated with IL-13 poly I:C for 24 h. Co-cultivation of moMφs moDCs increased TSLP level only in effect stimulation differed all groups. Asthma expressed higher receptors...
Background. The cross-talk between the external and internal environment in respiratory tract involves macrophage/dendritic cell (DC) transepithelial network. Epithelium triggers dendritic cell-mediated inflammation by producing thymic stromal lymphopoietin (TSLP), IL-33, IL-17A. study aimed to evaluate expression of TSLP, IL-17A human monocyte derived cells (moDCs) co-cultured with epithelium macrophages (moMφs) asthma, chronic obstructive pulmonary disease (COPD) healthy controls. Methods....
Sarcoidosis is a systemic disease of unknown etiology characterized by granuloma formation in the affected tissues. The pathologically activated macrophages are causatively implicated pathogenesis and play important role formation. Chitotriosidase (CHIT1), macrophage-derived protein, upregulated sarcoidosis its levels correlate with severity implicating CHIT1 pathology.CHIT1 was evaluated serum bronchial mucosa mediastinal lymph nodes specimens from patients. therapeutic efficacy OATD-01...