A5020156222- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Intracerebral and Subarachnoid Hemorrhage Research
- Immunotherapy and Immune Responses
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Child Nutrition and Water Access
- Antibiotic Resistance in Bacteria
- Alcoholism and Thiamine Deficiency
- Pulmonary Hypertension Research and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Renal and Vascular Pathologies
- Body Composition Measurement Techniques
- Intellectual Property Rights and Media
- Cancer Research and Treatments
- Telomeres, Telomerase, and Senescence
- Growth Hormone and Insulin-like Growth Factors
- CAR-T cell therapy research
- Pneumocystis jirovecii pneumonia detection and treatment
- Toxin Mechanisms and Immunotoxins
- Biochemical Analysis and Sensing Techniques
- Obstructive Sleep Apnea Research
Poznan University of Medical Sciences
2014-2024
Adam Mickiewicz University in Poznań
2020
Centrum Onkologii
2016-2019
University Hospital of Lord’s Transfiguration
2017
Cystic fibrosis (CF) is one of the most common autosomal recessive diseases. Factors contributing to disease exacerbations and survival rate CF patients are type mutation in CFTR gene, poor nutritional status, lung failure, infection development by Pseudomonas aeruginosa. The study aimed evaluate relationship between severity mutation, function, aeruginosa prevalence adult with cystic fibrosis.A 124 (68 ♀ 56 ♂) adults aged 18-51 years were evaluated for (a) (b) status (BMI), (c) function...
Cancer metastatic spread to serous cavity causes malignant pleural effusions (MPEs), indicating dismal prognosis. Tumor microenvironment can implement suppressive activity on host immune responses. Thus, we investigated the prevalence of Tregs and relationship between them TGF- β IL-10 concentrations measured expression FOXP3 , CTLA-4 CD28 GITR genes, as well protein selected genes in benign MPEs. The percentage was determined by means multicolor flow cytometry system. were using human 1...
We aimed to assess a liposomal fat-soluble vitamin formulation containing K2 with standard treatment in cystic fibrosis (CF). A multi-center randomized controlled trial was carried out 100 pancreatic-insufficient patients CF. The contained as retinyl palmitate (2667 IU daily) and beta-carotene (1333 IU), D3 (4000 E (150 K1 (2 mg), menaquinone-7 (400 µg). It compared the preparations closest possible doses (2500 IU, 1428 4000 150 2.14 mg, respectively; no K2) over 3 months. Forty-two finished...
Introduction: Bronchial artery embolisation (BAE) is one of the methods used in massive and recurring haemoptysis. The aim study to determine effectiveness complications bronchial Material methods: analysis included 47 procedures performed on 30 patients treated between 2011 2017 Department Respiratory Medicine, Allergology Pulmonary Oncology due patient’s age ranged 18 71 years, while mean at time BAE was 33.5 years. Patients with tuberculosis constituted 73.33% (n = 22) sample underwent 31...
Several factors could lead to lipid disturbances observed in cystic fibrosis (CF). This study aimed assess sterol homeostasis CF and define potential exogenous endogenous determinants of dysregulation.The involved 55 patients 45 healthy subjects (HS). Sterol concentrations (μg/dL) were measured by gas chromatography/mass spectrometry. was characterised lung function, pancreatic status, liver disease diabetes coexistence, Pseudomonas aeruginosa colonisation BMI. CFTR genotypes classified as...
In recent years, questionnaires were published in English to assess the quality of life patients with PCD (Primary Ciliary Diskinesia) for adults, adolescents aged 13–17 and children 6–12 years their caregivers. This study aimed prepare Polish versions validate them specific age groups participation PCD. The individual translated discussed involvement creator original questionnaire English. Patients completed according affiliation one groups. Validation was based on internal consistency...
We hypothezied that telomere length is considerably altered in cystic fibrosis (CF) patients compared to healthy subjects (HS), and leukocyte variation reflects the severity of CF. Relative (RTL) was assessed by qPCR 70 children aged 5–10 (34 CF; 36 HS) 114 adults 18–45 (53 61 HS). Telomere similar CF HS (median (interquartile range): 0.799 (0.686–0.950) vs. 0.831 (0.707–0.986); p = 0.5283) both adults. In adults, women had longer telomeres than men (0.805 (0.715–0.931) 0.703 (0.574–0.790);...
Interstitial pneumonia with autoimmune features (IPAF) is a term to describe individuals both interstitial lung disease (ILD) and combinations of other clinical, serologic, and/or pulmonary morphologic features, which presumably originate from an underlying systemic condition, but do not meet current rheumatologic criteria for defined connective tissue (CTD). Predominantly, arises in the course established CTD, it so rare ILD be first, possibly one only manifestation latent CTD. Lymphocytic...
The study aimed to assess: (1) differences in nutritional status and lung function between CF patients the control group; (2) body composition groups of with designated by type mutation; (3) relationship patients.
 We studied 37 aged 19 51 years, 41 healthy non-CF volunteers. Nutritional was evaluated based on BMI bioelectrical impedance analysis. described FEV1%. were classified according CFTR genotype five classes mutations.
 lower compared reference group (women: Z = 3.76, p...
Impulse oscillometry (IOS) has been proved to be an interesting alternative for other lung function measurements, as requires only passive cooperation and brings information on mechanical properties of respiratory system. The resistive component IOS studied extensively, however there is little the usefulness reactance, namely X5 (reactance at 5 Hz). We have analyzed data gathered in 55 adult patients with CF (20M; 35F age: 18-49 yrs): impulse oscillometry, spirometry body plethysmography....
We assumed that miRNA expression in exhaled breath condensate (EBC) during pulmonary exacerbation (PE) may reflect pathological changes the airways cystic fibrosis. The aim of this study was to analyse selected genes EBC samples fibrosis and correlate it clinical parameters PE. included 31 patients stable condition. In all subjects we assessed blood morphology, microbiology, lung function chest imaging. Severity symptoms using Schwachman–Kulczycki score. Exhaled were collected TurboDeccs. 5...
The main aim of this study was to evaluate whether selected polymorphic variants in genes from the inflammatory pathway can be predictors pulmonary or digestive manifestation cystic fibrosis, as well severity lung disease.
Urticaria is one of the most common skin disorders. A characteristic feature this disease sudden appearance and rapid regression (up to 24 hours) blisters, angioedema, or both these simultaneously. Often, above changes are accompanied by symptoms itching pain. Chronic urticaria, i.e. that lasts for at least 6 weeks, divided into spontaneous (CSU) induced. CSU, because its unpredictable nature, strongly reduces quality life, especially patient's active professionally socially. Below a...