A5071416153- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Nutrition and Health in Aging
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Neonatal Respiratory Health Research
- Advanced Chemical Sensor Technologies
- Metabolomics and Mass Spectrometry Studies
- Congenital Diaphragmatic Hernia Studies
- Body Composition Measurement Techniques
- Healthcare Systems and Public Health
- Systemic Sclerosis and Related Diseases
- Nutrition and Health Studies
- Genomics, phytochemicals, and oxidative stress
- Advanced Computing and Algorithms
- Biomarkers in Disease Mechanisms
- Mining and Industrial Processes
- Advanced Proteomics Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- IL-33, ST2, and ILC Pathways
- Inflammation biomarkers and pathways
- Neuroscience of respiration and sleep
- Chronic Disease Management Strategies
Poznan University of Medical Sciences
2013-2024
Tobacco smoking is the main etiological factor of lung cancer (LC), which can also cause metabolome disruption. This study aimed to investigate whether observed metabolic shift in LC patients was associated with their status. Untargeted metabolomics profiling applied for initial screening changes serum profile between and chronic obstructive pulmonary disease (COPD) patients, selected as a non-cancer group. Differences metabolite profiles current former smokers were tested. Then, targeted...
Abstract Genome-wide association studies have identified loci at 15q25 ( IREB2 ) and 4q22 FAM13A ), associated with lung cancer (LC) chronic obstructive pulmonary disease (COPD). The aim of our research was to determine the SNPs LC severe/very severe COPD patients. We examined variants (rs2568494, rs2656069, rs10851906, rs13180) (rs1903003, rs7671167, rs2869967) among 1.141 participants (468 LC, 149 COPD, 524 smoking controls). frequency minor rs2568494 AA genotype, higher in vs controls P =...
This study aimed to examine the distribution of predefined phenotypes, demographic data, clinical outcomes, and treatment patients who were included in Polish cohort Phenotypes COPD Central Eastern Europe (POPE) study.This was a sub-analysis data from POPE study, an international, multicenter, observational cross-sectional survey European countries. The aged >40 years, with confirmed diagnosis COPD, absence exacerbation for at least 4 weeks before inclusion. A total seven centers...
Chronic obstructive pulmonary disease (COPD) is associated with various comorbidities, which influence the course of COPD and worsen prognosis.The aim this study was to analyze comorbidities in a cohort patients Poland during 12 months observation.A total 444 (median age: 66.1 years) all stages airflow limitation severity were enrolled. Medical histories questionnaire concerning analyzed at baseline after (data 267 available). Anthropometric data, function, body mass index, obstruction,...
Introduction: Taking into account important role of apoptosis in COPD pathogenesis, we wanted to asses the serum levels markers involved regulation, including inducers such as TNF-α, sFasL or p53 protein and inhibitor bcl-2 and, addition, compare these with selected parameters. Material methods: In 181 patients (60 women) (age was 62.2 + 9.37 years; FEV1% 55.2 19.98 %) 29 controls (11 women), sFasL, were evaluated by enzyme-linked immunosorbent assay (ELISA) method. Results: mean level 0.092...
The role of natural killer (NK) cells in chronic obstructive pulmonary disease (COPD) pathogenesis has been discussed but is not yet clearly understood. This current study aimed to evaluate the associations between immunophenotypes, degrees maturity, and expression level functional receptors NK lung environment present bronchoalveolar lavage fluid (BALF), an attempt was made determine their relationship course progression COPD. A total 15 COPD patients 14 healthy smokers were included....
INTRODUCTION Myeloid‑derived suppressor cells (MDSCs) have the potent ability to suppress T‑cell function, and are important in regulation of chronic inflammation carcinogenesis. MDSCs may influence local systemic carcinogenesis COPD; however, their presence bronchoalveolar lavage fluid (BALF) peripheral blood (PB) or relationship with clinical parameters COPD has not been studied yet. OBJECTIVES The aim study was assess BALF PB analyze between COPD. PATIENTS AND METHODS included 64 patients...
Flexible video bronchoscopy (FVB) performed under sedation is a useful procedure in adults with cystic fibrosis (CF). Propofol dosage for CF poorly described, although it of high importance professionals. The study aimed to assess whether propofol should be higher undergoing during FVB.50 adult and non-CF patients FVB were included. Clinical features studied assessed. In group spirometry, liver enzymes, inflammatory biomarkers, albumin, protein concentration, WBC estimated. fentanyl was...
Wstęp: Proces apoptozy może odgrywać ważną rolę w patogenezie przewlekłej obturacyjnej choroby płuc (POChP). Autorzy ocenili stężenie markerów związanych z regulacja apoptozy, tym indukujących apoptozę—TNF-α, sFasL i białka p53 oraz hamujących apoptozę—bcl-2. Ponadto pracy oceniono związek pomiędzy badanymi markerami a parametrami klinicznymi POChP. Materiał metody: Do grupy badanej włączono 181 chorych na POChP (60 kobiet, wiek 62.2 ± 9.37 lat, FEV1% 55.2 19.98%), grupa kontrolna złożona...
Objective. The quality of spirometry manoeuvres is crucial for correctly interpreting the values parameters. A fundamental guideline proper assessment American Thoracic Society and European Respiratory (ATS/ERS) Standards spirometry, updated in 2019, which describe several start-of-test end-of-test criteria can be assessed automatically. However, standards also require a visual evaluation curve to determine spirograms' acceptability or usability. In this study, we present an automatic...