A5018608559- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sarcoidosis and Beryllium Toxicity Research
- Asthma and respiratory diseases
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Eosinophilic Esophagitis
- Medical Imaging and Pathology Studies
- Long-Term Effects of COVID-19
- Occupational exposure and asthma
- Dermatology and Skin Diseases
- Studies on Chitinases and Chitosanases
- COVID-19 Clinical Research Studies
- Skin Protection and Aging
- Pediatric health and respiratory diseases
- Occupational and environmental lung diseases
- Heart Rate Variability and Autonomic Control
- Nail Diseases and Treatments
- Inflammasome and immune disorders
- Oral Health Pathology and Treatment
- Heart rate and cardiovascular health
Medical University of Lodz
2012-2024
Guangzhou Medical University
2019
Bạch Mai Hospital
2019
First Affiliated Hospital of Guangzhou Medical University
2019
Boehringer Ingelheim (China)
2016
National Academy of Medicine
2013
Wojskowy Instytut Medycyny Lotniczej
2011
Kiel University
2008-2009
Centralny Szpital Kliniczny
1990
Bronchopulmonary signs and symptoms are examples of variable extraintestinal manifestations the inflammatory bowel diseases (IBD).These complications Crohn's disease (CD) ulcerative colitis (UC) seem to be underrecognized by both pulmonary physicians gastroenterologists.The objective present review was gather summarize information on this particular matter, basis available up-to-date literature.Tracheobronchial involvement is most prevalent respiratory presentation, whereas IBD-related...
Interleukin(IL)-33 is an epithelial alarmin important for eosinophil maturation, activation and survival. The aim of this study was to examine the association between IL-33, its receptor expression airway eosinophilic inflammation in non-atopic COPD. IL-33 concentrations were measured exhaled breath condensate (EBC) collected from healthy non-smokers, asthmatics COPD subjects using ELISA. Serum sputum samples smokers patients. Based on count, divided into subgroups with (sputum eosinophils >...
The role of mitochondria in post coronavirus disease 2019 (post-COVID-19) complications is unclear, especially the long-term pulmonary complications. This study aims to investigate association between post-COVID-19 and mitochondrial regulatory proteins context oxidative stress.Patients who had recovered from COVID-19 were enrolled. According evidence persistent interstitial lung lesions on computed tomography (CT), patients divided into a group (P(+)) control without (P(-)). We randomly...
(1) Introduction: The role of soluble integrins in post-COVID-19 complications is unclear, especially long-term pulmonary lesions. purpose this study was to investigate the association between ITGa2, ITGaM and ITGb2 integrin subunits long COVID-19 complications. (2) Methodology: Post-COVID-19 patients were enrolled. According evidence persistent interstitial lung lesions on CT, divided into a group (P(+)) control without (P(-)). We randomly selected 80 for further investigation (40 subjects...
Idiopathic pulmonary fibrosis (IPF) is a progressive and inevitably fatal disease with heterogeneous clinical course. This study aimed to evaluate the usefulness of circulating biomarkers in routine IPF practice. We conducted an exploratory cohort 28 subjects qualified for anti-fibrotic therapy up 24 months serial measurements seven biomarkers, including those that are well-established, Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), matrix metalloproteinase 7 (MMP-7), more...
Background Although chitin is absent in humans, chitinases are present healthy subjects and show dysregulated expression a variety of diseases resulting from abnormal tissue injury repair responses. It was shown that chitotriosidase (chitinase 1/CHIT1) structurally-related chitinase 3-like 1 protein (CHI3L1/YKL-40) play important roles the pathobiology idiopathic pulmonary fibrosis (IPF), however little known about their longitudinal serum levels relationship to clinical measures IPF....
Introduction: This document presents the Guideliness of Polish Respiratory Society (PTChP, Polskie Towarzystwo Chorób Płuc) for diagnosis and treatment idiopathic pulmonary fibrosis (IPF), developed by agroup experts. Material methods: The recommendations were in form answers to previously formulated questions concer-ning everyday diagnostic therapeutic challenges. They based on acurrent literature review using Grading Recommendations Assessment, Development Evaluation (GRADE) methodology....
Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPDs) are one the most important clinical aspects disease, and when requiring hospital admission, they significantly contribute to mortality among COPD patients. Our aim was assess role eosinopenia neutrophil-to-lymphocyte count (NLR) as markers in-hospital length hospitalization (LoH) patients with ECOPD hospitalization. We included 275 Eosinopenia associated deaths only coexisted lymphocytopenia, specificity 84.4% (95% CI...
Chronic obstructive lung diseases, such as asthma and COPD, appear to have a more extensive impact on overall functioning than previously believed. The latest data from clinical trials suggests potential link between cognitive deterioration chronic inflammatory disease. This raises the question of whether these diseases affect functions any relevant biomarker may be identified.
Background: Despite the absence of endogenous chitin in humans, chitinases are present serum healthy subjects and their levels increased a variety chronic inflammatory conditions. It has been shown that chitotriosidase structurally related chitinase-like protein-YKL-40 contribute to pathogenesis COPD. However, details regarding relation systemic local airways remain unknown. Objectives: To examine peripheral blood sputum YKL-40 expression smokers patients with Methods: Forty COPD, 20 10...
Abstract COPD has been regarded as a global epidemic due to an increase in pollution and tobacco exposure. Therefore, the study of molecular mechanism basis for modern therapy is important. The aim was assessment gene expression levels, IL-6 , IL-6ST PIAS3 STAT3 miRNAs, miRNA-1, miRNA-106b, miRNA-155, patients with COPD. Induced sputum well PBMC were collected from 40 clinically verified according GOLD 2021 (A–D) classification control group (n = 20). levels miRNA analysed by qPCR. In...
Introduction: Oxidative stress is a non-specific feature of airway inflammation in asthmatics.8-Isoprostane (8-IP), prostaglandin-F 2α isomer, relatively new marker oxidative and may be measured exhaled breath condensate (EBC) patients with asthma.This research study aimed to evaluate the usefulness EBC 8-IP as severity control severe adult asthma.Material methods: Twenty-seven severe, never-smoking asthmatics were studied.According positive or negative reversibility testing, this group was...
Sarcoidosis is a systemic granulomatous disease with variety of presentations. One the known symptoms are altered vitamin D metabolism and hypercalcemia. In our study, we aimed to assess associations between activity, inflammatory parameters, calcium status. The secondary aim was find any dependencies fatigue quality life in patients sarcoidosis. We enrolled 58 sarcoidosis (47 classified as active disease, 11 non-active) compared them 25 healthy volunteers. Calcium concentration...
Antifibrotic therapies reduce lung function decline in patients with idiopathic pulmonary fibrosis (IPF). This single-arm, open-label, nonrandomized study aimed to determine the influence of antifibrotic treatment on patients' reported symptoms and expectations therapy.Fifty-two confirmed IPF at a mean age 65 ± 8.63 years (73% male) completed following surveys baseline after 12 months Pirfenidone treatment: Short Form Healthy Survey (SF-36), St. George's Respiratory Questionnaire (SGRQ),...
Abstract Background Pirfenidone is an antifibrotic agent approved for the treatment of idiopathic pulmonary fibrosis (IPF). The drug available Polish patients with IPF since 2017. PolExPIR study aimed to describe real-world data (RWD) on experience pirfenidone therapy in respect safety and efficacy profiles. Methods This was a multicentre, retrospective, observational collecting clinical receiving from January 2017 September 2019 across 10 specialized centres Poland. Data collection included...
<b>Proximity extension assay proves feasible for multiplex analysis of proteins in bronchoalveolar lavage. Small exploratory study found multiple inflammatory that differed between patients with sarcoidosis and idiopathic pulmonary fibrosis.</b>https://bit.ly/3nW14nF
Recently, epithelial alarmins have been shown to play important roles in non-allergen driven respiratory diseases like idiopathic pulmonary fibrosis (IPF). Little is known about the expression of IPF. This study aimed prospectively examine interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) levels serum exhaled breath condensate (EBC) patients with IPF before after one-year antifibrotic treatment. A total 82 volunteers, including 52 diagnosed that qualified for therapy as...