A5053460689- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Medical Imaging and Pathology Studies
- Pediatric health and respiratory diseases
- Vascular Anomalies and Treatments
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Occupational exposure and asthma
- Inflammasome and immune disorders
- Neonatal Respiratory Health Research
- Tuberous Sclerosis Complex Research
- High Altitude and Hypoxia
- Eosinophilic Disorders and Syndromes
- Pulmonary Hypertension Research and Treatments
- Thyroid Disorders and Treatments
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Occupational and environmental lung diseases
- Foreign Body Medical Cases
Medical University of Lodz
2016-2025
Clinica de Pneumologie Iaşi
2023
Houston Advanced Research Center
2015-2017
ENT and Allergy
2015-2017
The role of mitochondria in post coronavirus disease 2019 (post-COVID-19) complications is unclear, especially the long-term pulmonary complications. This study aims to investigate association between post-COVID-19 and mitochondrial regulatory proteins context oxidative stress.Patients who had recovered from COVID-19 were enrolled. According evidence persistent interstitial lung lesions on computed tomography (CT), patients divided into a group (P(+)) control without (P(-)). We randomly...
This study evaluates the usefulness of serum KL-6, SP-D and TGF-β1 levels in assessing lung impairment predicting interstitial disease (ILD) short-term progression patients with pneumonia autoimmune features (IPAF). A total 24 IPAF, 21 connective tissue disease-associated ILD (CTD-ILD) 23 CTD without were followed for 1 year. Serum measured their associations severity analysed. significantly higher IPAF CTD-ILD compared to (p < 0.0001, p = 0.0005 respectively). KL-6 (r 0.45, 0.002) 0.35,...
(1) Introduction: The role of soluble integrins in post-COVID-19 complications is unclear, especially long-term pulmonary lesions. purpose this study was to investigate the association between ITGa2, ITGaM and ITGb2 integrin subunits long COVID-19 complications. (2) Methodology: Post-COVID-19 patients were enrolled. According evidence persistent interstitial lung lesions on CT, divided into a group (P(+)) control without (P(-)). We randomly selected 80 for further investigation (40 subjects...
Idiopathic pulmonary fibrosis (IPF) is a progressive and inevitably fatal disease with heterogeneous clinical course. This study aimed to evaluate the usefulness of circulating biomarkers in routine IPF practice. We conducted an exploratory cohort 28 subjects qualified for anti-fibrotic therapy up 24 months serial measurements seven biomarkers, including those that are well-established, Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), matrix metalloproteinase 7 (MMP-7), more...
Background Although chitin is absent in humans, chitinases are present healthy subjects and show dysregulated expression a variety of diseases resulting from abnormal tissue injury repair responses. It was shown that chitotriosidase (chitinase 1/CHIT1) structurally-related chitinase 3-like 1 protein (CHI3L1/YKL-40) play important roles the pathobiology idiopathic pulmonary fibrosis (IPF), however little known about their longitudinal serum levels relationship to clinical measures IPF....
Exacerbations of COPD (ECOPD) are important events in the course and they accelerate rate decline lung function, exacerbations requiring hospitalization associated with significant mortality. Therefore, developing approaches prevention early treatment ECOPDs special clinical interests. One such is telecare, including home telemonitoring.Daily telemonitoring HR, BP, SpO2 spirometry was performed. Variables were compared using bootstrap-boosted inference tests: paired t-test or Wilcoxon signed...
Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPDs) are one the most important clinical aspects disease, and when requiring hospital admission, they significantly contribute to mortality among COPD patients. Our aim was assess role eosinopenia neutrophil-to-lymphocyte count (NLR) as markers in-hospital length hospitalization (LoH) patients with ECOPD hospitalization. We included 275 Eosinopenia associated deaths only coexisted lymphocytopenia, specificity 84.4% (95% CI...
To characterize the eosinophilic granulomatosis with polyangiitis (EGPA) population from POLVAS registry depending on ANCA status and diagnosis onset, including their comparison (GPA) subset elevated blood eosinophilia (min. 400/
Chronic obstructive lung diseases, such as asthma and COPD, appear to have a more extensive impact on overall functioning than previously believed. The latest data from clinical trials suggests potential link between cognitive deterioration chronic inflammatory disease. This raises the question of whether these diseases affect functions any relevant biomarker may be identified.
This is the first study assessing clinical management of severe, isolated dysphonia during post-COVID-19 syndrome. One hundred and fifty-eight subjects met inclusion criteria for condition as specified by WHO. Six patients were diagnosed with severe dysphonia, constituting 3.8% initial group. The pre- post-examination protocol consisted subjective voice self-assessment routine laryngological examination, followed an instrumental examination means Laryngovideostroboscopy (LVS) High-Speed...
Despite growing knowledge about transmission and relatively wide access to prophylaxis, the world is still facing a severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) global pandemic. Under these circumstances telemedicine emerges as powerful tool for safe at-home surveillance after hospital discharge; data on when safely release patient COVID-19 scarce. Reckoning an urgent need improving outpatient management possibly fatal complications of post-COVID period, we performed pilot...
Sarcoidosis is a systemic granulomatous disease with variety of presentations. One the known symptoms are altered vitamin D metabolism and hypercalcemia. In our study, we aimed to assess associations between activity, inflammatory parameters, calcium status. The secondary aim was find any dependencies fatigue quality life in patients sarcoidosis. We enrolled 58 sarcoidosis (47 classified as active disease, 11 non-active) compared them 25 healthy volunteers. Calcium concentration...
<b>Proximity extension assay proves feasible for multiplex analysis of proteins in bronchoalveolar lavage. Small exploratory study found multiple inflammatory that differed between patients with sarcoidosis and idiopathic pulmonary fibrosis.</b>https://bit.ly/3nW14nF
Recently, epithelial alarmins have been shown to play important roles in non-allergen driven respiratory diseases like idiopathic pulmonary fibrosis (IPF). Little is known about the expression of IPF. This study aimed prospectively examine interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) levels serum exhaled breath condensate (EBC) patients with IPF before after one-year antifibrotic treatment. A total 82 volunteers, including 52 diagnosed that qualified for therapy as...
ARTICLE MLPR in the diagnosis of PE coexisting with AECOPD 15 et al 8 reported a pooled prevalence unexplained 16.1%.COPD may contribute to pulmonary vascular alterations, including medial wall thickening and muscularization arterioles. 9,10Moreover, higher hypertension patients COPD increased resistance beds, as well stagnation blood flow. 11,12PE has been shown increase rate INTRODUCTION Pulmonary embolism (PE) is common disorder associated significant morbidity mortality. 1,2Moreover,...
Granulomatosis with polyangiitis (GPA, previously known as Wegener’s granulomatosis) is a type of ANCA-associated vasculitis that affects small- to medium-sized vessels. GPA occurs prevalence 24–152:1000000. The disease all races at every age. Various factors may have an impact on the etiology which treated autoimmune disease. Genetic factors, infectious agents (like Staphylococcus aureus), environmental silica, hydrocarbons, fumes, pesticides, and farming) are considered elements for...
Introduction: Exacerbations of COPD (ECOPDs) are important events in the course COPD, accelerating rate decline lung function and increasing mortality risk. A growing body evidence suggests significance "frequent exacerbator" phenotype. This phenotype seems to be associated with a more severe airflow limitation, symptoms, health-related quality life impairment, higher mortality. However, there is no described biomarker that would help identify this group patients. Patients methods: "D" GOLD...