A5050668864- Gut microbiota and health
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Probiotics and Fermented Foods
- Microbial Community Ecology and Physiology
- Bacteriophages and microbial interactions
- Nail Diseases and Treatments
- Fungal Biology and Applications
- Food Safety and Hygiene
- Listeria monocytogenes in Food Safety
- Antifungal resistance and susceptibility
- Inflammatory Bowel Disease
- Inflammatory Biomarkers in Disease Prognosis
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Essential Oils and Antimicrobial Activity
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Gastrointestinal motility and disorders
- CAR-T cell therapy research
- Mycobacterium research and diagnosis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
University of Life Sciences in Poznań
2020-2025
Abstract Recent research indicates that gut microbiota may be vital in the advancement of melanoma. In this study, we found melanoma patients exhibited a distinct mycobiota structure compared with healthy participants. Candida albicans, dubliniensis, and Neurospora crassa were more abundant samples from melanoma, whereas Saccharomyces cerevisiae Debaryomyces hansenii less abundant. During anti–PD-1 treatment, relative amount Malassezia restricta C. albicans increased. A higher level...
Abstract Research has shown that the microbiome can influence how immune system responds to melanoma cells, affecting course of disease and outcome therapy. Here, we used metagenomic approach flow cytometry analyses blood cells discover correlations between gut fungi metastatic patients enrolled in anti-PD-1 therapy lymphocytes their blood. We analyzed patterns associations before first administration (BT, n = 61) third month (T3, 37), allowing us track changes during treatment. To...
Myeloid-derived suppressor cells (MDSC) are a subset of immature myeloid with suppressive activity well described in the context cancer. They inhibit anti-tumour immunity, promote metastasis formation and can lead to immune therapy resistance. In retrospective study, blood probes 46 advanced melanoma patients were analysed before first administration anti-PD-1 immunotherapy third month treatment for MDSC, monocytic (ImMC), MDSC (MoMDSC) granulocytic (GrMDSC) by multi-channel flow cytometry....
Antibiotic resistance is a global health problem, causing not only an increased mortality rate of bacterial infections but also economic losses due to, among other reasons, the need for longer hospital stays. Listeria monocytogenes one foodborne pathogens with ability to induce serious illness called listeriosis, approximately 20–30% fatal outcomes. The treatment regimen listeriosis in humans includes administration antibiotics (in most cases, ampicillin or trimethoprim sulfamethoxazole case...
The gut microbiota is considered a key player modulating the efficacy of immune checkpoint inhibitor therapy. study investigated association between response to anti-PD-1 therapy and baseline microbiome in Polish cohort melanoma patients, alongside selected agents modifying microbiome. Sixty-four patients enrolled for therapy, ten healthy subjects were recruited. treatment was assessed according evaluation criteria solid tumors, classified as responders or non-responders. extrinsic factors...
<p>Supplementary Figure 3. Relative abundance of Candida glabrata in normal (18.5</p>
<p>Supplementary Figure 7. Relative abundance of selected species during anti-PD-1 treatment.</p>
<p>Supplementary Figure Legends and Tables 2-9</p>
<p>Supplementary Figure 4. Phylogenetic trees of mycobiota in (A) healthy and (B) melanoma subjects.</p>
<p>Supplementary Figure 11. Relative abundance of selected species in responders and non (R vs. NR).</p>
<div>Abstract<p>Recent research indicates that gut microbiota may be vital in the advancement of melanoma. In this study, we found melanoma patients exhibited a distinct mycobiota structure compared with healthy participants. <i>Candida albicans</i>, dubliniensis</i>, and <i>Neurospora crassa</i> were more abundant samples from melanoma, whereas <i>Saccharomyces cerevisiae</i> <i>Debaryomyces hansenii</i> less abundant. During...
<p>Supplementary Figure 8. Relative abundance of statistically significant gut fungi species in overweight and normal BMI patients (A) before anti-PD-1 treatment, (B) the third month treatment.</p>
<div>Abstract<p>Recent research indicates that gut microbiota may be vital in the advancement of melanoma. In this study, we found melanoma patients exhibited a distinct mycobiota structure compared with healthy participants. <i>Candida albicans</i>, dubliniensis</i>, and <i>Neurospora crassa</i> were more abundant samples from melanoma, whereas <i>Saccharomyces cerevisiae</i> <i>Debaryomyces hansenii</i> less abundant. During...
<p>Supplementary Figure 9. Relative abundance of Yarrowia lipolytica in overweight patients during anti-PD-1 treatment.</p>
<p>Supplementary Figure 1. Baseline characteristics of the study populations with respect to (A) age groups, (B) BMI and (C) sex.</p>
<p>Supplementary Figure 10. Relative abundance of selected species in patients that exhibited benefits during anti-PD-1 treatment and who did not show (CB vs. NB).</p>
<p>Supplementary Figure 10. Relative abundance of selected species in patients that exhibited benefits during anti-PD-1 treatment and who did not show (CB vs. NB).</p>
<p>Supplementary Figure 2. (A) Shannon diversity of patients with normal (n=102) and elevated level serum LDH (n=16). Kruskal–Wallis test was performed to compare groups, p<0.05. Horizontal line shows median. The lower upper hinges correspond the first third quartiles. whiskers extend from hinge largest smallest value, respectively, no further than 1.5 * IQR (where is inter-quartile range, or distance between quartiles). Dots represent potential outliers. (B) Relative abundance...
<p>Supplementary Figure 5. The relative fungi abundance of melanoma and healthy samples at different taxonomical levels: (A) Phylum (B) Class (C) Order (D) Family.</p>
<p>Supplementary Figure 3. Relative abundance of Candida glabrata in normal (18.5</p>