A5045339907- Synthesis and biological activity
- Sirtuins and Resveratrol in Medicine
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Autophagy in Disease and Therapy
- Crystallization and Solubility Studies
- Cancer therapeutics and mechanisms
- Bioactive natural compounds
- Synthesis of heterocyclic compounds
- Safe Handling of Antineoplastic Drugs
- Crystal structures of chemical compounds
- Enzyme function and inhibition
- Multicomponent Synthesis of Heterocycles
- Metal complexes synthesis and properties
- Nonlinear Optical Materials Research
- Chemical Reaction Mechanisms
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Pharmaceutical studies and practices
- X-ray Diffraction in Crystallography
- Adipose Tissue and Metabolism
- Drug-Induced Adverse Reactions
- Synthesis and Characterization of Heterocyclic Compounds
Poznan University of Medical Sciences
2012-2021
Abstract Complexes of colchiceine with monovalent cation perchlorates and iodides have been obtained characterized by spectroscopic methods. DFT studies reveal that the dihedral angle ω 1‐1a‐12‐12a , crucial for colchicine biological mechanism action, is, binding to tubulins depends on diameter complexed metal cation. Biological tests indicated no antifungal properties (it was active only toward A.pullulans ), in contrast its derivative—(colchiceine). Complexation cations improved...
Abstract 10-Alkylthiocolchicines have been obtained and characterized by spectroscopic methods their biological activities as: cytotoxic, anti-inflammatory analgesic tested. Cytotoxic activity against SKOV-3 ovarian cell line for 10-alkylthiocolchicine analogues was reported tested compounds showed to be more active than commonly used doxorubicin. Some of C-10 alkylthiolated colchicines found exhibit cytotoxicity at levels comparable that the natural product—colchicine....
A series of new semi-synthetic 7-deacetyl-10-alkylthiocolchicne derivatives with ethyl, n-propyl, i-propyl and n-butyl substituents were synthesised characterised by spectroscopic methods, elemental analysis, DFT calculations molecular docking simulations. All the synthesized compounds have been tested for fungicidal anticancer activities against SKOV-3, LoVo, MCF-7, MDA-MB-231 lung-derived fibroblast CCD39Lu. colchicine exhibit significantly higher cytotoxicity towards SKOV-3 tumour cell...
Semi-synthetic C-10 alkyl thio analogues of the cytotoxic natural alkaloid colchicine have been found to exhibit cytotoxicity towards tumour cell lines at levels comparable that product. An efficient synthesis 10-alkyl thiocolchicines in mild conditions is proposed and products are studied by 1H 13C NMR, FT-IR, MS-EI methods elementary analysis. The crystal structure 10-ethylthiocolchicine characterised using X-ray diffraction methods. Cytotoxic activity against selected cancer for all...