There is limited information available regarding the association of plasma free fatty acids (FFA) and inflammation mediators with ischemic stroke. At same time, new treatment strategies are being pursued. The aim this study was to carry out a thorough analysis multiple FFA-derivative after stroke standard treatment. HPLC separations 17 eicosanoids were performed using an Agilent Technologies 1,260 liquid chromatograph. profiles esters labelled by means gas chromatography. FFA, eicosanoid in...

Recently, an increase in the incidence of inflammatory bowel disease (IBD) has been observed, especially among children and adolescents. Currently, few studies focus on differentiation inflammation IBD subunits, i.e., Crohn’s Disease (CD) Ulcerative Colitis (UC). The aim this study was to compare concentrations proinflammatory mediators arachidonic acid (ARA) linoleic (LA) patients with CD (n = 34) UC 30), order identify differences both diseases within same entity, according activity....

So far, it has been proven that benign prostatic hyperplasia (BPH) is strongly associated with inflammation resulting from, i.a. the presence of infectious agent, autoimmune disease, aging process and lipid disorders metabolic syndrome (MetS). We analyzed association between serum eicosanoides (HETE, HODE, lipoxins, prostaglandin, leucotrien) in man healthy controls. The study involved 219 men (with BPH, n = 144; controls, 75). assessed content arachidonic linoleic acid derivatives samples...

So far, there have been no analyses of correlations between the level water-soluble vitamins in women with polycystic ovary syndrome (PCOS) and hormone lipid profiles as well carbohydrate metabolism. The unpopular concept that PCOS may also be conditioned by a chronic infection leads to suspicion involved struggle against PCOS. This is why aim this research was determine whether are any indications could confirm hypothesis. study included 64 Caucasian race: 50 patients aged 29.52 ± 7.01...

Shift healthcare workers are a group particularly exposed to an increased risk of poor eating habits and affected by many diseases. The aim the study was evaluate dietary patterns (DPs), including Polish-adapted Mediterranean Diet (Polish-aMED®) score, fat intake in association with shift work workers. This cross-sectional involved 445 from West Pomeranian Poland. Dietary data were collected using FFQ-6®. A posteriori DPs derived Principal Component Analysis (PCA). Polish-aMED® score...

Objective To evaluate human oocyte ability to undergo fertilization and subsequent preimplantation embryonic development in relation a wide panel of follicular fluid (FF) arachidonic acid derivatives (AAD) linoleic (LAD) prospectively selected patients undergoing intracytoplasmic sperm injection (ICSI). Methodology Study was designed as two center (a university clinic private clinic) prospective study. 54 women 181 consecutive couples ICSI were found be eligible for analysis. 'One follicle –...

Fatty acid composition of human immune cells influences their function. The aim this study was to evaluate the effects known toxicant and immunomodulator, cadmium, at low concentrations on levels selected fatty acids (FAs) in THP-1 macrophages. differentiation monocytes into macrophages achieved by administration phorbol myristate acetate. Macrophages were incubated with various cadmium chloride (CdCl2) solutions for 48 h final 5 nM, 20 200 2 μM CdCl2. extracted from samples according Folch...

The outcome of kidney allograft transplantation is associated with numerous donor-dependent and recipient-dependent immunological non-immunological factors. Studies on genetic factors affecting the aspects, like ageing patient are still lacking. aim this study was analysis relative telomere length (RTL; T/S ratio) in biopsy specimens transplanted its correlation delayed graft function (DGF), acute rejection (AR) chronic dysfunction (CAD). enrolled 119 Caucasian recipients (64 M/55 F, mean...

Objective: The aim of this study was to determine the correlations between concentration tumor necrosis factor (TNF-α) and insulin-like growth I (IGF-I) in each woman with polycystic ovary syndrome (PCOS) phenotypes based on levels androgen.Methods: Two groups women PCOS differing their androgens. test group composed 39 according Rotterdam criteria reproductive age. hormonal luteinizing hormone (LH), follicle-stimulating (FSH), thyroid stimulating (TSH), prolactin (PRL), androstenedione,...

Genetic polymophisms of the Duffy antigen receptor for chemokines (DARC) gene successfully protected against blood stage infection by Plasmodium vivax infection. The Fy (a-, b-) phenotype is predominant among African populations, particularly those originating from West Africa, and it rare non-African populations. aim this study was to analyse frequency four groups based on SNPs (T-33C, G125A, G298A C5411T) in two local tribes Sudanese Arabs, Shagia Manasir, which are both region Fourth Nile...

Many researchers suggest an increased risk of atherosclerosis in women with polycystic ovary syndrome. In the available literature, there are no studies on mediators inflammation PCOS, especially after dietary intervention. Eicosanoids (HETE and HODE) were compared between biochemical phenotypes PCOS (normal high androgens) 3-month reduction diet. Eicosanoid profiles (9( S )-HODE, 13( 5( )-HETE, 12( 15( )-oxoETE, 16( R )-HETE ), 6( )-lipoxin A 4 , ) extracted from 0.5 ml plasma using...

An increase in IGF-I and TNF-α may be a cardioprotective effect. To examine the relationships between test anthropometric biochemical parameters before after low-glycemic index reduction diet using correlation matrix.Twenty-two women diagnosed with PCOS according to Rotterdam's criteria were eligible for this study, which analysed results three months dietary intervention. Body composition measurements determined by bioimpedance performed twice, along labelling of lipid, carbohydrate...

Fatty acid (FA) profiles in the plasma of patients with metabolic syndrome and chronic kidney disease (CKD) seem to be identical despite their different etiology (dietary mistakes vs. cachexia). The aim this study was compare both highlight differences that could influence improvement treatment groups. involved 73 women, including 24 treated haemodialysis, 19 (MetS), 30 healthy women control group. A total 35 fatty acids derivatives were identified quantified by gas chromatography....

Background: Non-alcoholic fatty liver disease (NAFLD) is a wide spectrum condition characterized by excessive fat accumulation in people who do not abuse alcohol. There no effective medical treatment for NAFLD; therefore, most important recommendations to reduce steatosis are diet and lifestyle, including proper physical activity. The aim of our study was analyze the acids eicosanoids changes serum patients consumed high-fiber rolls 8 weeks. Materials Methods: group 28 Caucasian participants...

A recurrent aphthous ulcer (RAU) is a common inflammatory ulcerative lesion affecting oral mucosa. We studied the eventual apoptosis of epithelial cells from point view and inflammation. RAU lesions healthy mucosa samples were immunostained for caspase-3 high-mobility group box 1 (HMGB1). DNA nicks identified using TUNEL staining. effects tumor necrosis factor α (TNFα) interferon γ (IFNγ) on toll-like receptor 2 4 (TLR2 TLR4) expression human SCC-25 keratinocytes. also self-DNA,...

Squamous cell carcinoma of the oral cavity mucosa grows under conditions poor oxygenation and nutrient scarcity. Reprogramming lipid biosynthesis accompanies tumor growth, but which it occurs are not fully understood. The fatty acid content serum, tissue adjacent microenvironment was measured by gas chromatography in 30 patients with squamous grade 1-3. Twenty-five acids were identified; their frequencies percentages each environments assessed. Nineteen twenty-five found tissue, blood serum....

Nonalcoholic fatty liver disease (NAFLD) is becoming a major public health problem worldwide. The study aimed to evaluate the concentration of eicosanoids in serum and tissue during steatosis progression assess whether eicosanoid change scores may predict remodeling. Thirty six eight-week-old male Sprague Dawley rats were enrolled sacrificed at different stages NAFLD. Eicosanoid concentrations, namely lipoxin A4, hydroxyeicosatetraenoic acids (HETE), hydroxyloctadecadienoic (HODE), protectin...

Recently, an increase in the incidence of inflammatory bowel disease (IBD) has been observed among children and adolescents. Although pathogenesis IBD is not fully elucidated currently, actual research focuses on occurrence imbalance between pro- anti-inflammatory molecules future identification role cytokines therapy. The purpose this study was to compare concentrations eicosapentaenoic docosahexaenoic acid derivatives during both phases Crohn's (CD) ulcerative colitis (UC). included 64...

Cerebral palsy (CP) results in non-progressive damage to the central nervous system, leading functional disorders of gastrointestinal tract and requiring enteral nutrition via gastrostomy some patients. The aim study was assess impact on intestinal inflammation expressed by stool calprotectin permeability determined fecal zonulin IFABP, determine whether CP affects these parameters. group consisted 30 children with CP, fed enterally (Cerebral Palsy Enteral Nutrition—CPEN), two reference...