A5005303538- Immune Cell Function and Interaction
- Infant Nutrition and Health
- Clinical Nutrition and Gastroenterology
- Childhood Cancer Survivors' Quality of Life
- Metabolism and Genetic Disorders
- Mast cells and histamine
- Polyamine Metabolism and Applications
- Neonatal skin health care
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Hepatocellular Carcinoma Treatment and Prognosis
- Multiple and Secondary Primary Cancers
- Dysphagia Assessment and Management
- Immunotherapy and Immune Responses
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Neonatal Health and Biochemistry
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Testicular diseases and treatments
- Asthma and respiratory diseases
- Autoimmune and Inflammatory Disorders Research
- Child Nutrition and Feeding Issues
- Cytomegalovirus and herpesvirus research
- Axon Guidance and Neuronal Signaling
Gdańsk Medical University
2014-2024
// Jacek J. Sznurkowski 1 , Anton Żawrocki 2 Katarzyna Sznurkowska 3 Rafał Pęksa and Wojciech Biernat Department of Oncological Surgery, The Medical University, Gdańsk, Poland Pathology, Pediatrics, Pediatric Gastroenterology, Hepathology Nutrition, Correspondence to: Sznurkowski, email: jacek.sznurkowski@gumed.edu.pl Keywords: vulvar SCC, PD-L1, HPV, p16, prognosis Received: July 13, 2017     Accepted: August 29, Published: September 15, 2017 ABSTRACT Background:...
Nijmegen breakage syndrome (NBS) is a human autosomal recessive disease characterized by genomic instability and enhanced cancer predisposition, in particular to lymphoma leukemia. Recently, significantly higher frequencies of heterozygous carriers the Slavic founder NBS1 mutation, 657del5, were found Russian children with sporadic lymphoid malignancies, Polish adults non-Hodgkin (NHL). In addition, substitution 643C>T (R215W) has also been excess among acute lymphoblastic leukemia (ALL). an...
Two studies were conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the skin-moisturizing effect in healthy adults and tolerability infants.In Study 1 (N = 44), single skin application of NTP-CE was performed followed by 4-week twice-daily application. Skin hydration stratum corneum (SC) water content change (using Raman spectroscopy) measured. In 2 65, aged 3-25 months), assessed using 5-point scoring system; determined subset 21).In 1, mean AUC0 - 24 h for...
The proportions of intestinal and peripheral regulatory T cells (Tregs) in pediatric inflammatory bowel disease (IBD) were poorly investigated, as well different subsets these cells. Helios Neuropilin-1 proposed markers differentiating between thymic Tregs. Therefore, the aim current work was to investigate Tregs expression blood mucosa children with disease.Fifteen patients newly diagnosed disease: ulcerative colitis (n=7) Crohn's (n=8) included study. Nine who presented no abnormalities...
To determine the proportion of T-regulatory cells (CD4+CD25highFOXP3+ cells) in peripheral blood and number FOXP3+ intestinal mucosa children with inflammatory bowel disease (IBD), to verify whether these parameters correlate activity disease.24 patients newly diagnosed for IBD were included study: ulcerative colitis (UC; n = 13) Crohn's (CD; 11). Seventeen healthy controls (HC) 16 irritable syndrome (IBS) served as a control group Tregs assessment, respectively. The was assessed by...
To assess the prevalence of UGT1A1*28 and UGT1A1*60 polymorphisms UGT1A1 gene their association with hyperbilirubinemia.The study was performed at a single centre - Department Obstetrics Medical University Gdansk in Poland. DNA isolated from Guthrie cards 171 infants. Only full term newborns (gestational age 38-42 weeks) were included study. Fluorescent molecular probes used for promoter variation analysis. The presence polymorphism detected dual-probe system, SimpleProbe™.Homozygous...
Cerebral palsy (CP) results in non-progressive damage to the central nervous system, leading functional disorders of gastrointestinal tract and requiring enteral nutrition via gastrostomy some patients. The aim study was assess impact on intestinal inflammation expressed by stool calprotectin permeability determined fecal zonulin IFABP, determine whether CP affects these parameters. group consisted 30 children with CP, fed enterally (Cerebral Palsy Enteral Nutrition—CPEN), two reference...
Background Juvenile idiopathic arthritis (JIA) is a chronic, heterogenous inflammatory disease of unclear pathogenesis. JIA hypothesized to be linked defective immune regulation. Anti-inflammatory cytokines belong the best known regulatory factors. T-regulatory cells are crucial cellular component tolerance. One their functions synthesis interleukin 10 (IL-10) and transforming growth factor beta1 (TGF-ß1).The aim this study was determine proportion (CD4+CD25highFOXP3+) in peripheral blood,...
A case of hepatic inflammatory pseudotumor mimicking malignancy in a 4-year-old girl with the Papillon-Lefevre syndrome (PLS) is reported. Only recently, an association between this inherited and liver abscesses has been found. Its possible pathogenesis discussed immunologic defects resulting from are presented. The development might be caused by disturbances staphylococcal infection. picture tumor on imaging patients PLS should attributed rather to than neoplastic process.
Histamine intolerance is defined as disequilibrium of accumulated histamine and the capacity for degradation. This clinical term addresses a non-immunologically mediated pathology when ingested with food not particularly high, but its degradation decreased. Clinical picture in children similar to that observed adults apart from male predominance found paediatric patients. Both adults, histamine-free diet seems be treatment choice. Diamine oxidase supplementation offers another option. There...
Implementation of hygienic measures and simple changes in the structure medical team may considerably reduce rate catheter-related bloodstream infections (CRBSIs) parenterally nourished patients.To analyze effects organizational parenteral nutrition services on CRBSI rates pediatric patients.We compared documented prior to, during after implementation (introduction a nutritional support related procedures, staff training).A total 260 courses were offered to 141 patients analyzed period....
Background: Mast cells are dispersed in many tissues, especially digestive and respiratory-tract mucosal membranes. Tryptase, considered a marker of mast-cell activity, is the most important protease released from these during degranulation. Tryptase concentration mainly accessed anaphylaxis mastocytosis, being one diagnostic criteria this disease. There no data concerning tryptase activity healthy children current literature. Aim: The aims study were analysis concentrations serum children,...
Autoimmune diseases due to probable common pathogenesis tend coexist in some patients. Complex clinical presentation with diverse timing of particular symptoms and sophisticated treatment numerous side effects, may cause diagnostic difficulties, especially children. The paper presents difficulties pitfalls a child Graves' disease, celiac disease liver function abnormalities.
Neopterin (NPT) (6-D-erythro-trihydroxypropyl pteridin) is one of the indicators immune system activity. Elevated neopterin concentration occurs in diseases mostly involving stimulation cellular immunity. The determination concentration, usually blood serum and urine but also many other bodily fluids, has already been applied areas medicine, such as transfusiology, transplantology, oncology, infectious autoimmunological diseases.The aim this work to evaluate clinical usefulness children with...
Background: Cystic fibrosis (CF) is characterized by malnutrition and chronic inflammation predominantly occurring in lungs. Evidence suggests a relation between inflammatory activity nutritional status. Proinflammatory cytokines, playing crucial role pulmonary destruction CF, are regarded as component of the pathogenesis illness-related malnutrition. Chemerin - novel marker crosstalk nutrition inflammation, has not been investigated children with cystic fibrosis. The aim this study was to...
The cholera vaccine can protect patients with inflammatory bowel disease (IBD) against both and travelers' diarrhea. However, immunosuppressive treatment IBD affect its immunogenicity. aim of this study was to assess the immunogenicity safety in children IBD. Children older than 6 years diagnosed were enrolled multicenter study. All administered two doses oral (Dukoral®). Anti-cholera toxin B subunit IgA IgG seroconversion rates evaluated a group (IS) without IS (NIS). Immunogenicity...
The purpose of this study was to compare the nutritional status between deltaF508 CFTR hetero- and homozygous paediatric patients with cystic fibrosis. We assessed percentage profiles fatty acids measured in erythrocyte membranes serum levels vitamins A, D3, E K1 studied groups. also weights heights calculated body mass indexes (BMIs). groups consisted 34 heterozygous 30 patients. No statistically significant differences were found or membrane acid patient groups, except for heptadecanoic (p...