A5012973952- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Colorectal and Anal Carcinomas
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Angiogenesis and VEGF in Cancer
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Multiple and Secondary Primary Cancers
- Chronic Lymphocytic Leukemia Research
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Intellectual Property Rights and Media
- Cancer, Lipids, and Metabolism
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- PARP inhibition in cancer therapy
- Banking Systems and Strategies
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related molecular mechanisms research
Gdańsk Medical University
2011-2023
Gdynia Maritime University
2023
University of Gdańsk
2016
Australia New Zealand Gynaecological Oncology Group
2011
<h3>Objective</h3> This study aimed to analyze the prognostic factors for overall and progression-free survival in patients with vulvar cancer. <h3>Methods</h3> international, multicenter, retrospective included 2453 diagnosed cancer at 100 different institutions. Inclusion criteria were institutional review board approval from each collaborating center, pathologic diagnosis of invasive carcinoma vulva, primary treatment performed participating center. Patients intraepithelial neoplasia or...
Background: The clinicopathological significance of the local spontaneous immune reaction in vulvar squamous cell carcinoma remains unclear. purpose this study was to clarify role subtypes tumor-infiltrating lymphocytes, both individually and synergistically. Methods: Seventy-six patients with verified histopathological data complete clinical history were included into study. We collected 76 paraffin-embedded samples primary tumor. presence CD4 + CD8 T cells evaluated by immunohistochemistry...
Adaptive immune effectors do not influence prognosis in vulvar squamous cell carcinoma (vSCC). Therefore, we tried to clarify the prognostic role of innate immunity and granzyme B-dependent cytotoxicity as defined by intratumoral infiltrates natural killer cells (CD56+) lymphocytes expressing B (GrB+). We analyzed 76 primary vSCCs 35 lymph node metastases that were obtained from patients with a full clinical history. The distribution density GrB+ CD56+ within cancer tissues evaluated...
We aimed to evaluate the correlation between p16(ink4a)-overexpression and high risk (hr)HPV-DNA in vulvar squamous cell carcinoma (vSCC) tumors as well impact of both biomarkers on prognosis vSCC patients.PCR-detection immunohistochemical staining for p16(ink4a) were conducted 85 tumors. Survival analyses included Kaplan-Meier method, log-rank test Cox proportional hazards model.p16(ink4a)-overexpression detected 35 37 tumors, respectively. Among p16(ink4a)-positive 10 lacked (29 %). 50...
// Jacek J. Sznurkowski 1 , Anton Żawrocki 2 Katarzyna Sznurkowska 3 Rafał Pęksa and Wojciech Biernat Department of Oncological Surgery, The Medical University, Gdańsk, Poland Pathology, Pediatrics, Pediatric Gastroenterology, Hepathology Nutrition, Correspondence to: Sznurkowski, email: jacek.sznurkowski@gumed.edu.pl Keywords: vulvar SCC, PD-L1, HPV, p16, prognosis Received: July 13, 2017     Accepted: August 29, Published: September 15, 2017 ABSTRACT Background:...
To investigate whether asymmetry exists in the left- and right-distribution of ovarian cystic lesions women with endometriosis.We evaluated operative reports who underwent surgical treatment endometrioma(n = 253) from January 1999 to December 2003. We included only those cases that had not been previously operated on (n 234). Data all findings consisted a written report diagram, fulfilling revised American Fertility Society Classification endometriosis.Endometrioma was found left ovary 113...
In 2009, International Federation of Gynecology and Obstetrics (FIGO) modified staging vulvar cancer—the prognostic significance the new classification relative to prior system as well commonly recognized factors has not been assessed. The aim this study was test ability 2009 in a cohort uniformly treated staged cases with long-term follow-up. Pathologic characteristics were obtained by blind review original tissue samples. 76 patients who qualified for surgery on basis same criteria, full...
ETIOLOGIAP onad 95% nowotworów złośliwych jajnika ma pochodzenie nabłonkowe.Do najważniejszych czynników ryzyka występowania raka należą:• nosicielstwo mutacji genów BRCA1
Background: Recent publications underscore the need for updated recommendations addressing less radical surgery <2 cm tumors, induction chemotherapy, or immunotherapy locally advanced stages of cervical cancer, as well systemic therapy recurrent metastatic cancer. Aim: To summarize current evidence diagnosis, treatment, and follow-up cancer provide evidence-based clinical practice recommendations. Methods: Developed according to AGREE II standards, guidelines classify scientific based on...
// Jacek J. Sznurkowski 1 , Anton Żawrocki 2 and Wojciech Biernat Department of Oncological Surgery, The Medical University, Gdańsk, Poland Pathology, Correspondence to: Sznurkowski, email: jacek.sznurkowski@gumed.edu.pl Keywords: vulvar SCC, p16, TILs, TAMs, prognosis Received: December 29, 2016 Accepted: April 04, 2017 Published: May 03, ABSTRACT Background: p16 Ink4a is not a surrogate marker for high-risk human papilloma virus (HPV) genotypes but indicates better in squamous cell...
To determine the proportion of T-regulatory cells (CD4+CD25highFOXP3+ cells) in peripheral blood and number FOXP3+ intestinal mucosa children with inflammatory bowel disease (IBD), to verify whether these parameters correlate activity disease.24 patients newly diagnosed for IBD were included study: ulcerative colitis (UC; n = 13) Crohn's (CD; 11). Seventeen healthy controls (HC) 16 irritable syndrome (IBS) served as a control group Tregs assessment, respectively. The was assessed by...
The resection of all visible malignancies increases the likelihood for long-term survival in epithelial ovarian cancer. complete extinguishment pelvic disease is possible using en bloc resection. no-touch isolation technique aims to reduce cancer cells flowing from primary tumor site liver and other organs by ligating blood lymphatic vessels first. objectives are present operative details establish feasibility modified resection, which begins with central ligation supplying bed. Twenty...