A5023857862- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Pharmaceutical studies and practices
- Drug Solubulity and Delivery Systems
- Surgical Sutures and Adhesives
- Analytical Methods in Pharmaceuticals
- Essential Oils and Antimicrobial Activity
- Lipid Membrane Structure and Behavior
- Contact Dermatitis and Allergies
- Analytical Chemistry and Chromatography
- Surfactants and Colloidal Systems
- Dermatology and Skin Diseases
- Ocular Surface and Contact Lens
- Proteins in Food Systems
- Epilepsy research and treatment
- Inflammatory mediators and NSAID effects
- Bee Products Chemical Analysis
- biodegradable polymer synthesis and properties
- Intramuscular injections and effects
- Inhalation and Respiratory Drug Delivery
- Cancer Treatment and Pharmacology
- Safe Handling of Antineoplastic Drugs
- Pharmacological Effects of Natural Compounds
- Pharmacological Effects and Toxicity Studies
- Nanoparticle-Based Drug Delivery
Gdańsk Medical University
2015-2025
University of California, San Francisco
1993-1995
In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use innovative additive manufacturing techniques offers possibility producing forms. this study, production mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two drugs, caffeine propranolol hydrochloride, were successfully processed into filaments hyprolose hypromellose as polymers. Subsequently, with diameters between 1.5 4.0 mm...
The production of orodispersible films (ODFs) with suspended insoluble drug substances is still a challenge, mainly due to the difficulty associated achieving proper homogeneity and mechanical properties films. Hypromellose (HPMC) mixture polyvinyl alcohol (AP) povidone (PVP) were compared in terms their suitability for ODFs incorporating micronized loratadine (LO) concentration range 10%-40%. In planetary mixer (Thinky), uniform dispersion LO an aqueous viscous casting solution was...
Streszczenie Przedmiot badań Keratopatia taśmowata (łac. keratopathia taeniata, ang. Calcific Band Keratopathy, CBK) to zwyrodnieniowa choroba rogówki spowodowana odkładaniem się białoszarego hydroksyapatytu wapnia w warstwach powierzchniowych tej tkanki, głównie błonie Bowmana. Celem leczenia jest usunięcie złogów wapniowych i przywrócenie prawidłowej przezierności rogówki. Najczęściej stosowana metoda polega na chirurgicznym zdjęciu nabłonka odsłonięciu zwapnienia, które następnie poddaje...
Solid lipid microparticles (SLMs) are multi-compartment drug carriers that can be used in various forms via many routes of administration, primarily to obtain prolonged release, protect the substance or mask its taste. It is practically impossible theoretically predict effectiveness incorporation and distribution active pharmaceutical ingredients (APIs) SLMs, these fundamental features determine key properties dosage form. The possibility an effective assessment by selecting developing...
The addition of polysorbate 20 (T20) is required to achieve "sink" conditions during a dissolution test for tablets with candesartan cilexetil (CC). Polysorbate (0.35%-0.7% w/w) added 0.05 mol/L phosphate buffer pH 6.5 dramatically increased the apparent solubility drug from 0.8 μg/ml even 353 μg/ml, while its effect in lower or water was much smaller (20 4.5). concentration salts (0.2 mol/l) at presence 0.7% 20, resulted further increase 620 μg/ml. change 1.2 7.4 1.5-fold activation energy...
Dermal or transdermal patches are increasingly becoming a noteworthy alternative as carriers for active pharmaceutical ingredients (APIs), which makes their detailed physicochemical evaluation essential development. This paper demonstrates mid-infrared (FTIR) and Raman spectroscopy with complementary microscopic methods (SEM, optical confocal microscopy) differential scanning calorimetry (DSC) tools the identification of state model API (testosterone TST, cytisine CYT indomethacin IND) in...
The aim of this study was to find a biocompatible, lecithin-based carrier for paclitaxel (PTX) suitable intravenous infusion and ensuring soluble PTX concentration 100 mg/100 ml or higher at least 24 h. Aqueous dispersions egg soya lecithin (water–lecithin dispersions, WLD), mixed micellar (MM) solutions sodium deoxycholate, formulations containing plus the co-surfactants co-solvents poloxamer, polysorbate, Span, benzalkonium chloride, macrogol were investigated. Amorphous prepared by...
Context: Keloids and hypertrophic scars are hyperproliferative skin disorders resulting in abnormal wound healing. In the prevention treatment of keloids scars, ointments containing heparin onion extract very popular. Their therapeutic effects, however, still controversial mechanism action is not fully understood.Objective: The aim this study was to assess effect enoxaparin dry on proliferation, apoptosis β1 integrin expression human fibroblasts.Materials methods: Fibroblast cell lines (46...
Abstract This study comprises the optimization and validation of a new TLC method for determination flavonols in bulbs seven cultivars onions shallots. Separation was performed on RP-18 plates with solvent mixture tetrahydrofuran/water/formic acid (40+60+6, V/V/V) as mobile phase. The evaluated precision, linearity, LOD, LOQ, accuracy robustness. Chromatographic analysis extracts revealed presence three main flavonols, quercetin, quercetin-4′-O-glucoside quercetin-3,4′-O-diglucoside majority...
Solid lipid microparticles (SLM) can be presented as liquid suspension or spray-dried powder. The main challenge in SLM technology is to precisely determine the location of active substance (API) different compartments formulation and its changes during processing. Therefore, purpose research was assess distribution API investigate nature API-lipid interaction when subjected spray drying, with an indication most suitable techniques for this purpose. were prepared two various lipids...