Background/Objectives: Elevated body temperature is a well-established biomarker of infection, increased disease risk, and adverse health outcomes. However, the relationship between resting long-term survival in older individuals complex. Emerging evidence suggests that higher basal associated with reduced accelerated aging non-obese adults. This study aimed to compare temperatures across different age groups hospitalized Methods: Data were retrospectively collected from 367 physically...

The aim of the study was to characterize effects a multi-strain synbiotic in patients with moderate severe irritable bowel syndrome (IBS) all stool form types. A total 202 adult IBS were randomized (1:1) and after four-week treatment-free run-in phase treated either or placebo for 12 weeks. primary endpoints assessment severity symptoms (IBS-SSS) improvement global (IBS-GIS). Secondary comprised adequate relief (IBS-AR scale), type (Bristol Stool Form Scale), movements, abdominal pain...

So far, it has been proven that benign prostatic hyperplasia (BPH) is strongly associated with inflammation resulting from, i.a. the presence of infectious agent, autoimmune disease, aging process and lipid disorders metabolic syndrome (MetS). We analyzed association between serum eicosanoides (HETE, HODE, lipoxins, prostaglandin, leucotrien) in man healthy controls. The study involved 219 men (with BPH, n = 144; controls, 75). assessed content arachidonic linoleic acid derivatives samples...

Effective thermoregulation is crucial for maintaining homeostasis. Previous research has suggested a link between lower steady-state body temperature and longevity, particularly in physically healthy, nonobese older adults. However, the exact mechanisms behind this relationship remain unclear. Despite physiological insights gained from studies on temperature, limited attention been given to its potential role as biomarker of longevity healthy populations. This study aimed evaluate using...

The development of a substance use disorder (SUD) is multifaceted process influenced by both genetic and environmental factors. Recent research has suggested the potential involvement HINT1 gene in various aspects plasticity, mood regulation, anxiety-like behaviour, stress-coping mechanisms. Moreover, personality traits are also recognised to be instrumental developing dependency. Given these considerations, our study investigated associations among cigarette smoking, traits, rs2526303...

The susceptibility to cannabis dependency results from the influence of numerous factors such as social, genetic, well epigenetic factors. Many studies have attempted discover a molecular basis for this disease. However, our study aimed at evaluating connection between altered methylation dopamine transporter gene (DAT1) promoter CpG sites and dependency. In cases some DNA sequences, including DAT1 region, their status in blood cells may reflect systemic modulation whole organism....

DNA methylation (leading to gene silencing) is one of the best-studied epigenetic mechanisms. It also essential in regulating dynamics dopamine release synaptic cleft. This regulation relates expression transporter (DAT1). We examined 137 people addicted nicotine, 274 subjects, 105 sports subjects and 290 from control group. After applying Bonferroni correction, our results show that as many 24 out 33 CpG islands had statistically significantly higher nicotine-dependent athletes groups...

Substance addiction is a neuropsychiatric disorder characterized by recurring desire to continue using substance despite harmful consequences. Brain-derived neurotrophic factor (BDNF) protein that plays role in the activity-dependent remodeling of neural function adult nervous systems. This study analyzed association rs6265 polymorphism BDNF gene group patients addicted psychoactive substances who were participating treatment for first time, post-relapse abusers and control group. The also...

Research into sports participation has increasingly pointed to inherent biological mechanisms as influential factors alongside psychosocial and environmental elements. The dopaminergic D2 receptor is a strong candidate gene for physical activity behaviour, given its role in locomotor control reward mechanisms. Hence, this study aimed analyse the association of DRD2 Tag1B rs1079597 polymorphism with personality traits elite athletes. group consisted 395 volunteers. Of these, 163 were...

Physical performance has been the focus of studies examining genetic influences in martial arts. There little quantitative analysis interaction between psychological traits and gene variants athletes. This study aimed to determine whether rs4680 polymorphism COMT (catechol-O-methyltransferase) was linked other sports phenotypes such as temperament, mental toughness, stress tolerance. In our study, we concentrated on case-control athletes aspect their personality association with...

Many factors are involved in addiction. The dopaminergic system is thought to be the key element this process. mesolimbic dopamine a crucial reward system. Changes leading substance use disorders and dependence. Therefore, for our study we chose an analysis of two polymorphisms genes (Variable Number Tandem Repeats DRD4 DAT1) responsible transmission, which might implicated scores personality traits measured by NEO-FFI test. group consisted 600 male volunteers-299 addicted subjects 301...

Brain-Derived Neurotropic Factor (BDNF) is one of the essential mediating factors exercise-induced neuroplasticity, but underlying molecular mechanisms neuroplasticity are still largely unknown. Personality dimensions differentiate individuals and depend on genes environmental factors. The openness to experience, emotional stability, extraversion conscientiousness have been reported be positively related performance; considering agreeableness, a negative relation with sports performance was...

The connection between the rate of height loss in older people and their general health status has been well documented medical literature. Our study was aimed at furthering characterization this interrelationship context indices mortality a hospitalized population Polish adults. Data were collated from literature review longitudinal aging carried out which followed 142 physically healthy inmates, including 68 men 74 women, for least 25 years age 45 onwards. Moreover, cross-sectional data...

Longitudinal studies of aging concerning individuals with comparable lifestyle, diet, health profile, socioeconomic status, and income remain extraordinarily rare. The purposes our ongoing project are as follows: (i) to collect extensive data on biological medical aspects in the Polish population, (ii) determine factors affecting rate course aging, (iii) understand how unfolds a dynamic malleable process ontogeny, (iv) find novel predictors longevity. Our investigation followed 142...

1. Vereczkey A, Demetrovics Z, Szekely Sarkozy P, Antal P Szilagyi et al. Multivariate analysis of dopaminergic gene variants as risk factors heroin dependence. PLoS One. 2013; 8e66592. CrossRef Google Scholar

Presently, a growing popularity of electronic cigarettes may be observed. Used as means obtaining nicotine they allow to substitute traditional cigarettes. The origins substance use disorders are conditioned by dopaminergic signaling which influences motivational processes being elementary factors conditioning the process learning and exhibiting goal-directed behaviors. study concentrated on analysis three polymorphisms located in dopamine receptor 2 (DRD2) gene—rs1076560, rs1799732...

Alcohol use disorder is considered a chronic and relapsing affecting the central nervous system. The serotonergic system, mainly through its influence on mesolimbic dopaminergic reward has been postulated to play pivotal role in underlying mechanism of alcohol dependence. study aims analyse association rs6295 polymorphism 5HTR1A gene women with personality traits development dependence, as well interaction rs6295, traits, anxiety dependence women. group consisted 213 female volunteers: 101...

The factors influencing the development and maintenance of nicotine dependence are numerous complex. Recent studies indicate that smokers exhibit distinct genetic predispositions to dependence. We aimed analyse (1) association between rs2551038 cigarette smoking, (2) rs3864236–rs2526303–rs2551038 haplotype (3) personality traits measured by NEO Five-Factor Inventory in users never-smokers. No significant differences were present frequency genotypes alleles studied compared control group....

A recent clinical (ViIBS) trial investigating the effects of a balanced multi-strain synbiotic in irritable bowel syndrome (IBS) patients showed that twelve weeks treatment resulted significant improvements across all major IBS symptoms. The current observational study pursued three aims: investigate patients' attitude towards intake pro- or synbiotics during six months after finishing their participation, determine severity symptoms, and assess diagnosis scores.

Personality traits and temperament may affect sports performance. Previous studies suggest that dopamine play an important role in behavior regulation physical exercise The aim of this study is to determine associations between D4 receptor gene (DRD4 Ex3) polymorphisms personality (such as neuroticism, extraversion, openness, agreeability conscientiousness) elite combat athletes. A total 302 physically active, unrelated, self-reported Caucasian participants were recruited for study....

Development of an addiction is conditioned by many factors. The dopaminergic system has been shown to be the key element in this process. In paper, we analyzed influence dopamine receptor 2 polymorphism rs1076560 two groups-polysubstance-dependent male patients (n = 299) and controls matched for age 301). both groups, applied same questionnaires testing-Mini-international neuropsychiatric interview, NEO Five-Factor Inventory, State-Trait Anxiety Inventory. real-time PCR method was used...

Background: Approximately 25–50% of people diagnosed with substance use disorder experience psychiatric disorders, and this percentage is even higher if subclinical psychopathological symptomatology taken into consideration. ”Dual diagnosis” implies the comorbidity two disorders (mental addiction), but in a clinical setting, numerous dual diagnoses involve multiple addictions (polysubstance means concurrent more than one psychoactive substance). Clinical observations epidemiological studies...

Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, in CHRNA5/A3/B4 gene cluster on chromosome 15 encode α5, α3, β4 subunits have recently received lot attention. Importantly, this been associated with addiction. significant cluster, polymorphism SNP rs16969968 seems to be most interesting factor This causes an amino acid change from aspartate asparagine at position 398 α5 nicotinic receptor protein...

Research on the hypodopaminergic hypothesis of addictions showed that activity in males predicted number drugs used and is associated with drug-seeking behavior. Variant alleles may cause functioning as a result reduced density dopamine receptors, decreased response to dopamine, increased clearance or metabolism reward system. The catechol-O-methyltransferase (COMT) involved dopamine. Personality traits mediate genetic predisposition substance use disorders additively by various motivations...