A5002652913- Fungal Infections and Studies
- Genetics and Physical Performance
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antifungal resistance and susceptibility
- Toxoplasma gondii Research Studies
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Adipokines, Inflammation, and Metabolic Diseases
- Probiotics and Fermented Foods
- Immune Response and Inflammation
- Sports Performance and Training
- Cardiovascular Effects of Exercise
- Cardiovascular and exercise physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Neonatal and fetal brain pathology
- Behavioral Health and Interventions
- Obesity, Physical Activity, Diet
- Barrier Structure and Function Studies
- Nutrition, Genetics, and Disease
- Phagocytosis and Immune Regulation
- Vitamin C and Antioxidants Research
- Melanoma and MAPK Pathways
- Piperaceae Chemical and Biological Studies
Gdansk University of Physical Education and Sport
2022-2025
Center for Health, Exercise and Sport Sciences
2023
University of Sheffield
2014-2022
Medical Research Council
2014
The proresolution therapeutic tanshinone IIA drives inflammation resolution by reverse migration.
Abstract Cryptococcus neoformans is a significant fungal pathogen of immunocompromised patients. Many questions remain regarding the function macrophages in normal clearance cryptococcal infection and defects present uncontrolled cryptococcosis. Two current limitations are: 1) The difficulties interpreting studies using isolated context progression infection, 2) use high resolution imaging understanding immune cell behavior during animal infection. Here we describe high-content method...
ERK5 regulates nonlytic expulsion of live pathogens from phagocytes to limit dissemination infections.
ABSTRACT The central nervous system (CNS) has specific barriers that protect the brain from potential threats and tightly regulate molecular transport. Despite critical functions of CNS barriers, mechanisms underlying their development function are not well understood, there very limited experimental models for study. Claudin 5 is a tight junction protein required blood barrier (BBB) and, probably, choroid plexus (CP) structure in vertebrates. Here, we show gene claudin 5a zebrafish...
Current approaches to tackling fungal infections are limited, and new targets must be identified protect against the emergence of resistant strains. We investigated potential targeting mitochondria, which organelles required for energy production, growth, virulence, in human pathogen Candida albicans . Our findings suggest that mitochondria can targeted using drugs tolerated by humans this treatment enhances their recognition immune cells. However, release C. cells from respiratory...
So far, Bacillus species bacteria are being used as concentrates, supplementing cleaning preparations in order to reduce odor and expel pathogenic bacteria. Here, we discuss the potential of ‘natural’ probiotics evaluate their microbiological characteristics. An industrially concentrates components mixed cultures were tested, which may be a promising source for food probiotic preparation supplementary diet. In this study, antagonistic activities species, derived from an industrial...
This cross-sectional study investigated the relationship between genetic variations in monocarboxylate transporter genes and blood lactate production removal after high-intensity efforts humans. The was conducted to explore how MCT1, MCT2, MCT4 influenced dynamics advance field of sports genetics by pinpointing critical markers that can enhance athletic performance recovery. 337 male athletes from Poland Czech Republic underwent two intermittent all-out Wingate tests. Before tests, DNA...
Meningitis caused by infectious pathogens is associated with vessel damage and infarct formation, however the physiological cause often unknown. Cryptococcus neoformans a human fungal pathogen causative agent of cryptococcal meningitis, where vascular events are observed in up to 30% patients, predominantly severe infection. Therefore, we aimed investigate how infection may lead dissemination using zebrafish model that permitted noninvasive vivo imaging. We find cells become trapped within...
There is a wide range of individual variability in the change body weight response to exercise, and this partly depends on genetic factors. The study aimed determine DNA polymorphisms associated with fat loss efficiency untrained women normal 12-week aerobic training program using GWAS approach, followed by cross-sectional athletes. involved 126 young Polish (age 21.4 ± 1.7 years; mass index (BMI): 21.7 (2.4) kg/m2) 550 Russian athletes (229 women, age 23.0 4.1; 321 men, 23.9 4.7). We...
400-m races are based on anaerobic energy metabolism, they induce significant muscle fatigue, fiber damage, and high blood lactate (LA) concentration. Despite extensive research sprint training, our understanding of the training process that leads to world-class performance is rather limited. This study aimed determine differences in LA concentration power using jumping tests after an intense glycolytic effort a group elite sub-elite runners. One hundred thirty male runners were divided into...
Physical performance has been the focus of studies examining genetic influences in martial arts. There little quantitative analysis interaction between psychological traits and gene variants athletes. This study aimed to determine whether rs4680 polymorphism COMT (catechol-O-methyltransferase) was linked other sports phenotypes such as temperament, mental toughness, stress tolerance. In our study, we concentrated on case-control athletes aspect their personality association with...
Human adipocytes release multiple adipokines into the bloodstream during physical activity. This affects many organs and might contribute to induction of inflammation. In this study, we aimed assess changes in circulating adipokine levels induced by intense aerobic anaerobic exercise individuals with different adipose tissue content. quasi-experimental 48 male volunteers (aged 21.78 ± 1.98 years) were assigned groups depending on their body fat content (BF): LBF, low (<8% BF, n = 16); MBF,...
Abstract Anti-proliferative agents that target lymphoid cells are common immunosuppressive used in the treatment of diverse autoimmune, graft versus host and inflammatory diseases. Mycophenolate mofetil (MMF) is an anti-proliferative agent targets dependence on inosine monophosphate dehydrogenase for de novo purine synthesis deoxyguanosine triphosphate (dGTP) DNA replication. Here we show MMF has a distinct specific vivo effect macrophages, absence cells. This results increased macrophage...
Dopamine receptor D2 gene (DRD2) polymorphisms have been associated with cognitive abilities, obesity, addictions, and physical-activity-related behaviors, which may underlie differences in the effectiveness of training programs. What is not yet clear impact DRD2 on exercise Thus, aim this study was to investigate association between polymorphic sites (rs1076560, rs12364283, rs1799732, rs1800497, rs1800498) body's response regular physical activity. We studied genotypes haplotypes...
Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed compare genotype distributions allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 HFE rs1799945 in Polish elite athletes versus nonathletes. Methods: involved 101 male 41 healthy individuals from population as a control group. SNP data extracted whole-genome sequencing (WGS) performed using following parameters: paired...
ABSTRACT The central nervous system (CNS) has specific barriers that protect the brain from potential threats and tightly regulate molecular transport. Despite critical functions of CNS barriers, mechanisms underlying their development function are not well understood, there very limited experimental models for study. Claudin 5 is a tight junction protein required blood barrier (BBB) choroid plexus (CP) structure in humans. Here, we show gene claudin 5a zebrafish orthologue with high...
Abstract The human fungal pathogen Candida albicans possesses two genes expressing a cyanide-insensitive Alternative Oxidase (Aox) enzymes in addition to classical and parallel electron transfer chains (ETC). In this study, we examine the role of Aox C . under conditions respiratory stress, which may be inflicted during its interaction with host or co-colonising bacteria. We find that level expression is sufficient modulate resistance ETC inhibition stress are linked gene changes can promote...
Background: To date, nearly 300 single-nucleotide polymorphisms (SNPs) associated with BMI, waist-to-hip ratio, and other adiposity traits have been identified by GWAS. With regards to IL10, at least 49 IL10-associated reported. However, little is known regarding the relationship between SNPs of IL10 gene risk obesity in young men. The aim present study was investigate IL10RB genes Methods: A cohort 139 male students were enrolled following analyzed: (rs1518110), (rs3024491), (rs2834167)....
Abstract Cryptococcus neoformans is an opportunistic fungal pathogen that can cause life-threatening cryptoccocal meningitis, predominantly within immunocompromised individuals. Cortical infarcts are observed in as many 30% of cryptococcal meningitis cases, being particularly common severe infection. Limited clinical case studies suggest secondary to vasculitis and blood vessel damage caused by However, the infection has not been determined. To examine potential causes vascular dissemination...
Abstract The human fungal pathogen C. albicans requires respiratory function for normal growth, morphogenesis and virulence. As such the mitochondria represent an enticing target development of new antifungal strategies. This possibility is further bolstered by presence specific characteristics. However, respiration in , as case many organisms, facilitated redundant electron transport mechanisms that makes direct inhibition a challenge. In addition, chemicals known to chain are highly toxic....