A5016249226- Skin Protection and Aging
- Pediatric Hepatobiliary Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Digestive system and related health
- Protease and Inhibitor Mechanisms
- Ear and Head Tumors
- Pancreatic function and diabetes
- Infant Nutrition and Health
- Smoking Behavior and Cessation
- Retinoids in leukemia and cellular processes
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Wound Healing and Treatments
- Infectious Aortic and Vascular Conditions
- Cardiac Fibrosis and Remodeling
- Pediatric health and respiratory diseases
- Skin and Cellular Biology Research
- Cardiac tumors and thrombi
- Personality Disorders and Psychopathology
- Adipokines, Inflammation, and Metabolic Diseases
- Galectins and Cancer Biology
- CNS Lymphoma Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Homicide, Infanticide, and Child Abuse
- Head and Neck Anomalies
Pomeranian Medical University
2016-2024
Jagiellonian University
2004
Using different three-drug immunosuppressive treatment regimens in a rat model, we aimed to determine the effects of long-term therapy on metalloproteinase-2 and metalloproteinase-9 activity expression their inhibitors, as well assess morphology animals' cardiac tissue. Our results suggest that chronic use drugs disrupts balance between MMPs TIMPs. Depending type drug regimen used, this leads abnormalities structure, collagen fiber accumulation, or cardiomyocyte hypertrophy. The information...
Presently, a growing popularity of electronic cigarettes may be observed. Used as means obtaining nicotine they allow to substitute traditional cigarettes. The origins substance use disorders are conditioned by dopaminergic signaling which influences motivational processes being elementary factors conditioning the process learning and exhibiting goal-directed behaviors. study concentrated on analysis three polymorphisms located in dopamine receptor 2 (DRD2) gene—rs1076560, rs1799732...
Immunosuppressive drugs are widely and chronically used to avoid graft rejection in transplant recipients. However, they also known have organotoxic effects can exert numerous side effects. The aim of this study was assess whether the chronic treatment rats with most commonly clinical immunosuppressive regimens organ recipients had an effect on morphology function aorta. were divided into five groups each group treated different sets three (TRG, CRG, MRG, CMG, TMG) for 6 months. changes...
Background: Immunosuppressive agents represent a broad group of drugs, such as calcineurin inhibitors, mTOR and glucocorticosteroids, among others. These drugs are widely used in number conditions, but lifelong therapy is crucial the case organ recipients to prevent rejection. To further increase safety efficacy these agents, their off-target mechanisms action, well processes underlying pathogenesis adverse effects, need be thoroughly investigated. The aim this study was examine impact...
Lactoferrin (LF) is an iron-binding glycoprotein from the transferrin family, which has been identified in most biological fluids as secretions exocrine glands and content of specific granules neutrophils. It reported to have numerous functions. Due antimicrobial anti-inflammatory activity, lactoferrin plays significant role host defense against infection extreme inflammation. Recent studies also demonstrated that LF can protect cancer experimental animals anticarcinogenic activity many...
Post-transplant diabetes mellitus (PTDM) is a common complication that occurs in kidney transplant patients, increasing the risk of infection, cardiovascular disease and loss graft function. Currently, factors increase this are being sought, among them polymorphisms genes regulate carbohydrate metabolism influence pancreatic β-cell The aim study was to evaluate association selected affecting metabolism, such as CDKAL1 rs10946398, GCK rs1799884, GCKR rs780094 DGKB/TMEM195 rs2191349, with...
The Taq1A polymorphism located in the ANKK1 gene is one of most widely studied polymorphisms regards to genetics behavior and addiction. aim our study was analyze this with regard personality characteristics anxiety measured by means Personality Inventory-(NEO Five-Factor Inventory-NEO-FFI) State-Trait Anxiety Inventory (STAI) polysubstance addicted subjects. group consisted 600 male volunteers, including 299 subjects 301 controls. Psychiatrists recruited members for both groups. Addiction...
Implantation of autologous fibroblasts is a method used to correct age-related changes in facial skin. The aim this study was establish the optimal population cultured human according organization extracellular matrix dermis. Transcriptome profile analysis cells derived from three consecutive passages indicated that after second passage were with greatest number upregulated genes encoding critical biological processes responsible for skin regeneration, such as organization, collagen fibril...
Skin aging is associated with both intrinsic and extrinsic aging, caused by environmental factors overlaying the effects of chronological aging. The main aim this study was to evaluate effect preparations containing Helix aspersa snail mucus on skin regeneration photoaging features. Before 3 months after series treatments, biopsy specimens from right preauricular region face were taken six women. Histological, morphometric, immunohistochemical analyses performed. Positive changes, indicating...
(1) Background: The main goal of this study was to analyze the morphology rat's jejunum after long-term treatment with calcineurin inhibitor-based immunosuppressive drugs and investigate their impact on location MMP-2 its inhibitor TIMP-2, as well balance between them. (2) Methods: Twenty-four rats were divided into four groups receiving different regiments. After six months treatment, jejunums collected analyzed. (3) Results: drug panels containing inhibitors (CNIs) have a negative...
Chronological skin ageing is an inevitable physiological process that results in thin and sagging skin, fine wrinkles, gradual dermal atrophy. The main therapeutic approaches to soft tissue augmentation involve using fillers, where natural such as autologous fibroblasts, are involved generating matrix proteins. aim of this study was determine the global transcriptome profile three passages fibroblasts from a male volunteer, focusing on processes cell cycle proliferation status estimate...
Abstract Introduction : Lactoferrin (Lf) is a protein in the transfer-rin family with many biological functions. One novel activity of lactoferrin described recently its regulatory function bone morphogenesis. has been shown to promote growth, development, and differentiation osteoblasts as well decrease osteoclast survival. receptors (LfRs) mediate multiple functions lactoferrin. This review focuses on LfRs associated intestines. The best known LfR small intestine (intelectin), which...