A5048599432- Eating Disorders and Behaviors
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Regulation of Appetite and Obesity
- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Prenatal Substance Exposure Effects
- Substance Abuse Treatment and Outcomes
- Bipolar Disorder and Treatment
- Eicosanoids and Hypertension Pharmacology
- Adolescent and Pediatric Healthcare
- Gestational Diabetes Research and Management
- Nicotinic Acetylcholine Receptors Study
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Personality Traits and Psychology
- Treatment of Major Depression
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
- Child Nutrition and Feeding Issues
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Personality Disorders and Psychopathology
- Child and Adolescent Psychosocial and Emotional Development
Pomeranian Medical University
2006-2023
Aim: The aim of this study was to evaluate functional catechol-<i>O</i>-methyltransferase (COMT) genetic variation as a risk factor for eating disorders (ED). <i>Method:</i> Eighty women receiving treatment serious ED (52 anorexia nervosa, 28 bulimia nervosa) and 116 age-matched females in the control group underwent COMT genotyping polymorphism exon 4 (codon 158). Both low-activity allele high-activity (H) were determined. <i>Results:</i> H/H genotype...
The aim of the current study was to analyze relationships between plasma hormones, body weight parameters and stressful life events in anorexia nervosa (AN).72 females active phase AN were evaluated. 52 healthy women constituted control group. RIA kits used measure hormone levels.The concentrations leptin, insulin, IGF-1, triiodothyronine, LH, FSH, estradiol, testosterone significantly lower those cortisol growth higher than No hormonal differences restrictive binge-purging subtypes found....
Smoking is a chronic and relapsing addictive trait that harms public health. Among the many identified genetic variants of nicotine dependence, in CHRNA5/A3/B4 gene cluster on chromosome 15 encode α5, α3, β4 subunits have recently received lot attention. Importantly, this been associated with addiction. significant cluster, polymorphism SNP rs16969968 seems to be most interesting factor This causes an amino acid change from aspartate asparagine at position 398 α5 nicotinic receptor protein...
Research on the hypodopaminergic hypothesis of addictions showed that activity in males predicted number drugs used and is associated with drug-seeking behavior. Variant alleles may cause functioning as a result reduced density dopamine receptors, decreased response to dopamine, increased clearance or metabolism reward system. The catechol-O-methyltransferase (COMT) involved dopamine. Personality traits mediate genetic predisposition substance use disorders additively by various motivations...
The dopaminergic system is a crucial element of the addiction processes. dopamine transporter modulates dynamics and levels released in synaptic cleft. Therefore, regulation (DAT1) gene expression critical for maintaining homeostasis system. aim our study evaluation methylation status 33 CpG islands located DAT1 promoter region related to nicotine dependency. We investigated 142 nicotine-dependent subjects 238 controls. Our results show that as many 14 tested had statistically significantly...
Compared to other addictive substances, patients with cannabis addiction are significantly outnumbered by those who report dependence on other, more substances. Unfortunately, most goes untreated, and among choose treatment, the requirements much higher for adolescents young adults. The aim of study: To examine relationship cannabinoid dependency in genetic context—the association between rs1799732 polymorphism DRD2 gene psychological traits anxiety. Methods: study group consisted 515 male...
The main aims of the present study were to explore relationship OPRM1 gene rs1074287 polymorphism in alcohol-dependent women with their personality traits and try find out whether any specific features may influence alcohol cravings be a prognostic for dependency treatment AUD women. Our found notable correlation between openness interaction ORIM1 AUD. use disorder subjects genotype AG showed higher level compared control group genotypes (p = 0.0001) AA 0.0125). displayed levels than...
Behavioural and emotional disturbances (F92.8) are the most recognized disorders in a developmental psychiatry. As problem is still alarmingly increasing, searches for their etiopathogenesis more effective preventing therapy methods required. The aim of study was to assess association between quality life, some psychopathological features, concentrations selected immunoprotective (brain-derived neurotrophin, BDNF), endocrine (cortisol, F) factors while adolescent disturbances. performed 123...
Prenatal alcohol exposure (PAE), which refers to consumption by pregnant women, is associated with the risk of numerous severe complications during fetal development. The State Agency for Alcohol Problem Solving reports that incidence spectrum disorder (FASD) in Poland’s general population over 1.7%, and syndrome (FAS) estimated at more than 0.5%. This study aimed evaluate significance focused on pattern intoxication exhibited mother pregnancy other environmental factors maternal environment...
Background: There has been a noticeable and systematic growth of the use psychoactive substances over past few decades. Dual diagnosis is clinical term referring to occurrence substance disorder comorbid with another psychiatric in same person. The most common type dual co-occurrence alcohol mood disorders form depressive episode. Co-occurrent are frequently influenced by genetic factors. In selecting our area research, we focused on dopamine DRD4 (Dopamine Receptor D4) gene polymorphism as...
Fetal alcohol spectrum disorders (FASD) in a course of high prenatal exposure (hPAE) are among the most common causes developmental disorders. The main reason for pharmacological treatment FASD children is attention deficit hyperactivity disorder (ADHD), and methylphenidate (MPH) drug choice. aim study was to assess whether born hPAE with ADHD, or without morphological FASD, differ terms catechol-O-methyltransferase (COMT) dopamine receptor D2 (DRD2) gene polymorphisms, if genetic...
The study aims at looking into associations between the polymorphism rs6276 that occurs in putative miRNA target site 3′UTR region of DRD2 gene patients with substance use disorder (SUD) comorbid a maniacal syndrome (SUD MANIA). In our study, we did not state any essential difference genotype frequencies studied samples SUD MANIA, SUD, and control subjects. A significant result was found for MANIA group vs. controls on Neuroticism Scale NEO FFI test, (p = 0.0320) accounted 1.7% variance. G/G...