Heavy metals may exacerbate metabolic syndrome (MS) but abnormal serum concentrations of bioelements also co-exist with MS. The primary aim the study was to assess relationship blood heavy metal and bioelement MS, in men aged 50–75 years. metals—lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), tungsten (W), Macroelements—magnesium (Mg) calcium (Ca), microelements—iron (Fe), zinc (Zn) copper (Cu), chromium (Cr), molybdenum (Mo), selenium (Se) manganese (Mn), body mass index (BMI), waist...

Gut microbiome-derived short-chain fatty acids (SCFAs) emerge in the process of fermentation polysaccharides that resist digestion (dietary fiber, resistant starch). SCFAs have a very high immunomodulatory potential and ensure local homeostasis intestinal epithelium, which helps maintain barrier. We analyzed association between stool levels acetic acid (C 2:0), propionic 3:0), isobutyric 4:0i), butyric 4:0n), isovaleric 5:0i) valeric 5:0n), isocaproic 6:0i), caproic 6:0n)) aging man with...

The aim of the study was to examine an in vitro effect three bacterial strains (Escherichia coli, Staphylococcus haemolyticus and Bacteroides ureolyticus) on ejaculated spermatozoa with reference sperm membrane integrity mitochondrial activity. carried out swim-up-separated from 12 normozoospermic volunteers. Sperm plasma stability evaluated by LIVE/DEAD Viability Kit merocyanine 540 test. Mitochondrial activity using JC-1 test as well NADH-dependent NBT assay. percentage dead cells...

The purpose of the study was to evaluate relationship between serum adiponectin and leptin concentrations body composition, hematological indices lipid profile parameters in adults. involved 95 volunteers (BMI from 23.3 53 kg/m²). Anthropometric were measured: weight height, waist hip circumference, waist-to-hip ratio, fat mass (BMF), subcutaneous visceral (SFM, VFM), lean (LBM), skeletal muscle (SMM). In we determined concentrations, extracellular hemoglobin, total bilirubin, as well...

So far, it has been proven that benign prostatic hyperplasia (BPH) is strongly associated with inflammation resulting from, i.a. the presence of infectious agent, autoimmune disease, aging process and lipid disorders metabolic syndrome (MetS). We analyzed association between serum eicosanoides (HETE, HODE, lipoxins, prostaglandin, leucotrien) in man healthy controls. The study involved 219 men (with BPH, n = 144; controls, 75). assessed content arachidonic linoleic acid derivatives samples...

It has been suggested that individuals with metabolic syndrome (MetS) may be prone to developing benign prostatic hyperplasia (BPH), but the direction of causality remains uncertain. The objective this cross-sectional study was evaluate association between BPH and MetS in men who were referred surgery for BPH. We interested identifying anthropometric, metabolic, hormonal factors potentially influence risk both conditions. conducted on 128 males 141 without (the control group). Fasting...

Technologies involved in roasting coffee beans, as well the methods used to prepare infusions, vary according culture, and contribute differences concentration of elements drink.Concentrations six elements: manganese (Mn), cobalt (Co), nickel (Ni), chrome (Cr), silver (Ag) lead (Pb) were investigated infusions from eleven samples coffee, roasted purchased four countries: Bosnia Herzegovina, Brazil, Lebanon Poland. Metal concentrations determined using an induction coupled plasma technique...

Lipid accumulation product (LAP) is an index used for evaluating lipid overaccumulation in adults. Our study aimed at assessing associations between LAP and metabolic syndrome (MetS) its components, age-related testosterone deficiency (TDS), low-density cholesterol (LDL), as well HOMA-IR (insulin resistance ratio), insulin level non-diabetics total (TT), estradiol E₂, dehydroepiandrosterone sulphate (DHEAs) sex hormone-binding globulin (SHBG) aging men. 313 men aged 50–75 were...

Although immune system plays a key role in the pathogenesis of both endometriosis and ovarian cancer, its function is different. Therefore, we hypothesized, that selected parameters can serve as diagnostic markers these two conditions. The aim this study was to compare serum peritoneal fluid concentrations sHLA-G, IL-10 TNF-alpha women with pathologies: benign serous cysts, endometrioma malignant tumors. Clinical significance using them for purposes endometriosis, which future may improve...

Introduction/Objective: The aim of the study was to show which adipose tissue accumulation indicators correlate with testosterone disorders in non-diabetic aging men. Material and methods: 455 non diabetic men, recruited at primary care facilities, aged 50–75 participated study. participants underwent anthropometric measurement ELISA determination total (TT), estradiol (E2), dehydroepiandrosterone sulphate (DHEA-S), sex hormone binding protein (SHBG), fasting glucose (FPG), high-density...

The aim of this study was to determine the relationship between serum magnesium (Mg) concentrations in middle-aged and older men, occurrence selected metabolic hormonal disorders. involved a total 313 men aged 50-75 years, who underwent standard anthropometric measurements. Also determined were blood Mg, lipid parameters - cholesterol (TCh), high-density lipoprotein (HDL), low-density (LDL), triglyceride (TG) carbohydrate metabolism glucose, insulin (I). In with normal testosterone (TT)...

Introduction: The etiology of benign prostatic hyperplasia (BPH) has not so far been fully explicated. However, it is assumed that changes in the levels hormones associated with aging can contribute to development hyperplasia. Dihydrotestosterone combines androgen receptor (AR) proteins prostate gland. Enzyme activity based on two isoenzymes: type 1 and 2. 5α-reductase encoded by SRD5A1 gene, 2 SRD5A2 gene. aim our study was determine frequency (rs6884552, rs3797177) (rs523349, rs12470143)...

Studies were performed on boar semen routinely used at the local artificial insemination (AI) centre. The was stored in a Safe Cell Plus commercial extender 17 degrees C for nine days. aim of our research focused changes sperm plasma membrane integrity. integrity and acrosome as well motility decreased after dilution during storage semen. highest percentage live identified by eosin-nigrosin method, lower SYBR-14/PI test, lowest cells discovered hypoosmotic swelling (HOS) test (P < 0.01)....

It is known that estrogens act on the male reproductive tract by binding to estrogen receptors (ER) a and b. However, studies ER localization in human testis are discordant. The aim of this study was investigate ERa testes adult men with normal spermatogenesis. Semen analysis ten revealed azoospermia. FSH, LH testosterone serum concentrations were within values, volume normal, hence obstructive azoospermia suspected. tissues from testicular surgical biopsies fixed Bouin's fluid embedded...

Low calorie intake, or restriction (CR) without malnutrition, has been demonstrated in several animal species, including mice, to increase both median and maximum lifespan as well delay reproductive senescence. Our previous work a positive correlation between life span the number of very small embryonic-like stem cells (VSELs) long living Laron dwarf mice. These animals have low levels circulating insulin-like growth factor 1 (IGF-1) peripheral blood (PB), maintain higher numbers...

It is known that estrogens act on the male reproductive tract by binding to estrogen receptors (ER) a and b. However, studies ER localization in human testis are discordant. The aim of this study was investigate ERa testes adult men with normal spermatogenesis. Semen analysis ten revealed azoospermia. FSH, LH testosterone serum concentrations were within values, volume normal, hence obstructive azoospermia suspected. tissues from testicular surgical biopsies fixed Bouin’s fluid embedded...

Both estrogens and androgens are involved in the development normal functioning of ovaries. It is also known that ovarian function regulated by diet. The goal this study was to estimate expression sex hormone receptors ovaries mice were on a 9-month caloric restriction (alternate-day feeding) as compared control animals fed ad libitum. We found prolonged mouse led increased estrogen (ERs) but did not affect androgen receptor (AR). This increase ER:AR ration result may lead higher sensitivity...

Abstract Background It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals, and one of the signs aging progressive gonadal dysfunction. Methods To study effects insulin-like growth factor-1 (IGF-1) plasma level on ovaries, we analyzed ovaries isolated from 2-year-old hormone receptor knockout (GHR-KO) Laron dwarf mice, with low circulating levels IGF-1, 6-month-old bovine transgenic (bGHTg) high IGF-1. The ages mutants employed our studies were...

It is well known that somatotrophic/insulin signaling affects lifespan in experimental animals. To study the effects of insulin-like growth factor-1 (IGF-1) plasma level on morphology major organs, we analyzed lung, heart, liver, kidney, bone marrow, and spleen isolated from 2-year-old hormone receptor knockout (GHR-KO) Laron dwarf mice (with low circulating levels IGF-1) 6-month-old bovine transgenic (bGHTg) high IGF-1). The ages two mutant strains employed our studies were selected based...