A5005087114- Telomeres, Telomerase, and Senescence
- Cytomegalovirus and herpesvirus research
- Multiple Myeloma Research and Treatments
- Mesenchymal stem cell research
- Hemoglobinopathies and Related Disorders
- Advanced biosensing and bioanalysis techniques
- Respiratory Support and Mechanisms
- Metabolism and Genetic Disorders
- Peripheral Neuropathies and Disorders
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- Bipolar Disorder and Treatment
- Long-Term Effects of COVID-19
- Renal and related cancers
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Dendrimers and Hyperbranched Polymers
- Potassium and Related Disorders
- Cancer Treatment and Pharmacology
- COVID-19 Clinical Research Studies
Pomeranian Medical University
2005-2022
The outcome of kidney allograft transplantation is associated with numerous donor-dependent and recipient-dependent immunological non-immunological factors. Studies on genetic factors affecting the aspects, like ageing patient are still lacking. aim this study was analysis relative telomere length (RTL; T/S ratio) in biopsy specimens transplanted its correlation delayed graft function (DGF), acute rejection (AR) chronic dysfunction (CAD). enrolled 119 Caucasian recipients (64 M/55 F, mean...
<b><i>Background/Aims: </i></b>It has been confirmed that telomere length (TL) correlates with chronological donor age and shortening is accelerated in allografts. The aim of this study was to analyse the associations between graft rs2735940 <i>hTERT</i> rs2630578 <i>BICD1</i> gene polymorphisms rs7235755/rs2162440 chromosome 18 polymorphisms, relative TL kidney function after transplantation. <b><i>Methods: </i></b>The...
BACKGROUND:There are several genes and genetic loci affecting telomere length, including hTERT gene BICD1 as well polymorphisms within chromosome 18. It has been demonstrated that the age of donor is a negative factor associated with long-term kidney allograft function, post-transplant complications accelerate transplanted organ aging, thus contributing to estimated glomerular filtration rate (eGFR) decreases. The aim this study was joint assessment donors’ recipients’ 18 regard early...
Multiple myeloma (MM) is a malignant, incurable neoplastic disease. The currently used treatment significantly improves the prognosis and extends survival time of patients. Unfortunately, common side effect therapy peripheral neuropathy, which may lead to dose reduction or complete discontinuation/modification. In this study, we examined changes in plasma levels circulating miRNAs patients define potential factors characteristic for drug-induced neuropathy (DiPN). Global miRNA expression...
The launch of novel chemotherapeutic agents-in particular, proteasome inhibitors and immunomodulatory drugs-dramatically changed multiple myeloma (MM) therapy, improving the response rate prolonging progression-free survival. However, none anti-MM drugs are deprived side effects. Peripheral neuropathy (PN) seems to be one most pressing problems. Despite extensive research in this area, pathogenesis drug-induced peripheral (DiPN) has not yet been fully elucidated. In present study, we aimed...
We present an extremely rare case report of a 29-year-old multiple myeloma patient with central nervous system involvement and secondary hemophagocytic lymphohistiocytosis (HLH). observed that HLH was presumably triggered by the immunomodulatory drug-lenalidomide. is frequently misdiagnosed or underdiagnosed. As requires immediate treatment, our emphasizes need to consider in differential diagnosis when condition receiving chemotherapy rapidly deteriorates infectious etiology excluded....
We present one of few cases COVID-19 occurrence during the early phase autologous hematopoietic stem cell transplantation. observed an interesting correlation between patient’s rapid clinical deterioration and myeloid reconstitution that cannot be assigned to engraftment syndrome. Our report emphasizes need investigate whether timely steroid therapy upon neutrophil in setting could limit extent lung injury prevent ARDS. Furthermore, we discuss a significant issue possible prolonged...