A5038866675- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Central Venous Catheters and Hemodialysis
- Histone Deacetylase Inhibitors Research
- Long-Term Effects of COVID-19
- Ubiquitin and proteasome pathways
- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- Metabolomics and Mass Spectrometry Studies
- Vascular Procedures and Complications
- COVID-19 and healthcare impacts
- Vitamin D Research Studies
- Dental Research and COVID-19
- Neuropeptides and Animal Physiology
- Mental Health Research Topics
- Laser Applications in Dentistry and Medicine
- Autoimmune and Inflammatory Disorders Research
- Acute Kidney Injury Research
- T-cell and B-cell Immunology
- Infection Control in Healthcare
- Kawasaki Disease and Coronary Complications
- Dermatologic Treatments and Research
- Body Image and Dysmorphia Studies
- Skin Protection and Aging
Pomeranian Medical University
2021-2024
Abstract Bernstein fits implemented into R allow another route for Kruskal-Wallis power-study tool development. Monte-Carlo power studies were compared with measured power, a ANOVA equivalent and an analytical method, or without normalization, using four simulated runs, each 60–100 populations (each population N = 30,000 from set of Pearson-type ranges): random selection gave 6300 samples analyzed predictive power. Three medical-study datasets (Dialysis/systolic blood pressure;...
The exact pathophysiology of severe COVID-19 is not entirely elucidated, but it has been established that hyperinflammatory responses and cytokine storms play important roles. aim this study was to examine CMV status, select chemokines, complement components in COVID-19, how concentrations given molecules differ over time at both molecular proteomic levels. A total 210 patients (50 ICU 160 non-ICU patients) 80 healthy controls were enrolled study. Concentrations chemokines (CXCL8, CXCL10,...
Esthetic medicine is a rapidly developing field of that not only beneficial in terms external appearance, but also significantly improves overall quality life. Currently, pigmented and vascular skin lesions are more prevalent due to multiple environmental factors characteristic manifestation aging. The development modern laser therapy has contributed the successful management conditions. aim our study was show effect concomitant reduction both hyperpigmented located on facial area after...
The management of patients undergoing HSCT requires a multipurpose central venous catheter. Peripheral catheters (PCs), such as peripherally inserted (PICCs) and MidLine (MLCs), appear to be adequate vascular used for stem cell infusion, although their utilization in this indication is not yet common. We analyzed the infectious complications blood stream infection (BSI), febrile neutropenia (FN) line-associated bloodstream (CLBSI) infusion through PC conventionally catchers (CICCs),...
Lenalidomide (LEN) is widely used immunomodulatory drug (IMiD). Nonetheless, despite its efficacy, over time patients become resistant to LEN and relapse. Due high clinical relevance, resistance in MM being thoroughly investigated. However, less known about predictors of good response LEN-based treatment. The aim this study was identify molecular pathways associated with long LEN. included newly diagnosed (NDMM) treated first-line dexamethasone (RD) who achieved least very partial remission...
Multiple myeloma (MM) remains an incurable hematological malignancy. Bortezomib (BTZ) is a proteasome inhibitor widely used in MM therapy whose potent activity often hampered by the development of resistance. The immune system vital pathophysiology BTZ Vitamins D (VD) and K (VK) modulate system; therefore, they are potentially beneficial MM. aim study was to evaluate effect VD VK supplementation on proliferation potential gene expression profiles cells terms U266 cell line incubated three...
Bortezomib-induced peripheral neuropathy (BiPN) occurs in approximately 40% of patients with multiple myeloma. The induction severe entails the dose reduction or complete elimination bortezomib (BTZ). Interestingly, discontinuation BTZ mostly results a resolution (PN) symptoms. Therefore, it is likely that BiPN mechanisms are based on temporary/reversible changes such as epigenetic alterations. In this study, we examined effect treating nerve cells, differentiated from Lund human...
Introduction: Due to the SARS-CoV-2 coronavirus pandemic, wearing of masks has become a common phenomenon. Most undesirable effects using protective face covering are usually related prolonged time its wearing, and adverse consequences coverings should be considered two-fold. The aim study was evaluate rate contamination three types (surgical, N95, FFP2 masks) with microorganism—aerobic bacteria, yeasts, molds—after 3 h exposure time. aimed investigate (KN95) on respiratory function...
The management of patients undergoing stem cell transplantation requires a multipurpose central venous catheter (CVC) to facilitate drug administration, parenteral nutrition, transfusion blood products, and collection samples. Peripherally inserted catheters (PICCs) appear meet these requirements but are rarely used for infusion. We aimed retrospectively assess the safety feasibility infusion through PICC evaluate its impact on kinetics. analyzed outcomes peripheral (PBSC) in receiving...
Multiple myeloma (MM) is a plasma cell malignancy that accounts for 1% of all cancers and the second-most-common hematological neoplasm. Bortezomib (BTZ) proteasome inhibitor widely implemented in treatment MM alone or combination with other agents. The development resistance to chemotherapy one greatest challenges modern oncology. Therefore, it crucial discover implement new adjuvant therapies can bypass therapeutic resistance. In this paper, we investigated vitro effect methylation...
The pathophysiology of the severe course COVID-19 is multifactorial and not entirely elucidated. However, it well known that hyperinflammatory response cytokine storm are paramount events leading to further complications. In this paper, we investigated vascular in aimed identify novel biomarkers predictive ICU admission. study group consisted 210 patients diagnosed with (age range: 18-93; mean ± SD: 57.78 14.16), while control 80 healthy individuals. We assessed plasma concentrations various...
The launch of novel chemotherapeutic agents-in particular, proteasome inhibitors and immunomodulatory drugs-dramatically changed multiple myeloma (MM) therapy, improving the response rate prolonging progression-free survival. However, none anti-MM drugs are deprived side effects. Peripheral neuropathy (PN) seems to be one most pressing problems. Despite extensive research in this area, pathogenesis drug-induced peripheral (DiPN) has not yet been fully elucidated. In present study, we aimed...
Bortezomib (BTZ) is widely implemented in the treatment of multiple myeloma (MM). Its main mechanism action very well established. BTZ selectively and reversibly inhibits 26S proteasome. More precisely, it interacts with chymotryptic site 20S proteasome therefore degradation proteins. This results intracellular accumulation misfolded or otherwise defective proteins leading to growth inhibition apoptosis. As as interfering ubiquitin–proteasome complex, elicits various epigenetic alterations...
We present an extremely rare case report of a 29-year-old multiple myeloma patient with central nervous system involvement and secondary hemophagocytic lymphohistiocytosis (HLH). observed that HLH was presumably triggered by the immunomodulatory drug-lenalidomide. is frequently misdiagnosed or underdiagnosed. As requires immediate treatment, our emphasizes need to consider in differential diagnosis when condition receiving chemotherapy rapidly deteriorates infectious etiology excluded....
For many years, intensive research has been carried out on the in-depth understanding of pathogenesis multiple myeloma (MM). Nevertheless, multifactorial nature disease, development drug resistance, and side effects therapy, make it difficult to effectively treat patients. One factors involved in MM is brain-derived neurotrophic factor (BDNF). This widely described as a neuroregenerative neuroprotective agent, but also regulates non-neuronal cell functions, such proliferation, apoptosis,...
ALS remains a fatal, neurodegenerative motor neuron disease. Numerous studies seem to confirm that innate immune system is involved in the pathophysiology of ALS. Hence, assessment complement and attempts modify its activity remain target medical intervention In present study, three intrathecal administrations autologous bone marrow-derived lineage-negative (Lin–) cells were performed every 6 weeks 20 sporadic patients. The concentrations various components cerebrospinal fluid plasma at...
Multiple myeloma (MM) is a plasma cell malignancy that, despite recent advances in therapy, continues to pose major challenge hematologists. Currently, different classes of drugs are applied treat MM, among others, proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies. Most them participate an interplay with the immune system, hijacking its effector functions redirecting anti-MM activity. Therefore, adjuvant therapies boosting system may be potentially beneficial MM...
Aesthetic medicine is a rapidly developing field of medicine. Every year the number patients who undergo cosmetic ambulatory procedures increases. The COVID-19 pandemic affected all branches healthcare including aesthetic Therefore, establishing safety protocol paramount importance in order to provide safe and ethical care.