A5068975299- Heavy Metal Exposure and Toxicity
- Dental Health and Care Utilization
- Facial Trauma and Fracture Management
- Oral health in cancer treatment
- Temporomandibular Joint Disorders
- Trypanosoma species research and implications
- Oral Health Pathology and Treatment
- Bone and Dental Protein Studies
- Cholesterol and Lipid Metabolism
- Fluoride Effects and Removal
- Trace Elements in Health
- Oral microbiology and periodontitis research
- Complement system in diseases
- Fatty Acid Research and Health
- Dental Radiography and Imaging
- Drug-Induced Ocular Toxicity
- Facial Nerve Paralysis Treatment and Research
- Restraint-Related Deaths
- HIV/AIDS oral health manifestations
- Aluminum toxicity and tolerance in plants and animals
- Nanoparticles: synthesis and applications
- Congenital Ear and Nasal Anomalies
- Hemophilia Treatment and Research
- Dental Education, Practice, Research
- Intraperitoneal and Appendiceal Malignancies
Pomeranian Medical University
2011-2024
Cadmium is a toxic and carcinogenic heavy metal that nowadays constitutes serious environmental health problem. The aim of this study to review the effects cadmium on selected inflammatory mediators markers, such as NF-κB AP-1 transcription factors, IL-6, TNF-α, IL-1β cytokines, IL-8 or MIP-2 chemokine, MPO, iNOS, MMPs COX-2 enzymes, PGE(2) (product enzyme), ICAM-1, VCAM-1 PECAM-1 adhesion molecules, CRP. research strategy identified articles available in Medline, published between 1998...
Objectives: This overview was conducted following the Preferred Reporting Items for Overviews of Reviews guidelines and aimed to collect compare results systematic reviews on temporomandibular joint injection treatment. Methods: Systematic randomized clinical trials disorders treated with lavage or intra-articular administrations were qualified syntheses. The final searches 27 February 2024, without time frame restrictions. Results: Of 232 identified records, 42 selected. most evidence-based...
The aim of the study was to examine whether MBL2 C(-290)G and G161A, MASP2 A359G, AMELX C287T C522T, ENAM C2452T polymorphisms are associated with dental caries.Genomic DNA 95 Polish children 'higher caries experience' (HC) 84 subjects 'lower (LC) belonging two age-groups (5 13 years old) extracted from buccal mucosa. SNPs were genotyped PCR-RFLP methods.Among 5-year-old children, we found significantly higher percentage carrying (-290)G allele in HC group compared LC (43.2%vs 17.6%, P =...
Abstract The lectin pathway of complement is an integral component innate immunity. It activated upon binding mannan-binding (MBL) or ficolins (H-, L-, and M-ficolin) to suitable ligand patterns on microorganisms. MBL are polydisperse homo-oligomeric molecules, found in complexes with MBL-associated serine proteases (MASP-1, -2, -3) proteins (MAp19 MAp44). This scenario far more complex than the well-defined activation classical pathway, C1qC1r2C1s2, composition activating ill defined. We...
Cadmium at environmental concentrations is a risk factor for many diseases, including cardiovascular and neurodegenerative in which macrophages play an important role. The aim of this study was to evaluate the effects cadmium low (nanomolar) on apoptotic processes THP-1(acute monocytic leukemia cells line)-derived macrophages, with special focus mitochondrial events involved. Macrophages were incubated various chloride (CdCl2) solutions 48 h final 5 nM, 20 200 nM 2 µM CdCl2. Cell viability...
Fatty acid composition of human immune cells influences their function. The aim this study was to evaluate the effects known toxicant and immunomodulator, cadmium, at low concentrations on levels selected fatty acids (FAs) in THP-1 macrophages. differentiation monocytes into macrophages achieved by administration phorbol myristate acetate. Macrophages were incubated with various cadmium chloride (CdCl2) solutions for 48 h final 5 nM, 20 200 2 μM CdCl2. extracted from samples according Folch...
The aim of this study was to examine the effects cadmium in concentrations relevant those detected human serum on cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) expression at mRNA, protein, enzyme activity levels THP-1 macrophages. Macrophages were incubated with various chloride (CdCl2) solutions for 48 h final 5 nM, 20 200 2 μM CdCl2. mRNA protein COXs analyzed RT-PCR Western blotting, respectively. Prostaglandin E2 (PGE2) stable metabolite thromboxane B2 (TXB2) culture media...
Significant progress in understanding the effects of neurotoxic action lead (Pb) young organisms had led to reduction "safe" level blood (Pb-B) 5 μg/dL children and pregnant women. Prolonged exposure relatively low levels Pb, generally asymptomatic subclinical (i.e., microintoxication), is currently dominant form environmental poisoning, its negative on health may appear after many years, e.g., secondary contamination from Pb bone deposits released pregnancy. Therefore, aim this study was...
Caries has a negative influence on health and is still public problem among children adolescents in Poland. The aim of this study was to analyze the association dietary habits, oral hygiene behaviors frequency usage dental services with caries index teenagers North-West enrolled 264 (147M/117F) aged 15. Participants filled out questionnaire regarding age, sex, visits dentist, habits behaviors, Decayed Missing Filled Teeth Index (DMFT) calculated. found 88.6% subjects. lower or no experience...
The aim of this study was to examine the association single-nucleotide polymorphisms (SNPs) in gene encoding ficolin-2 protein (<i>FCN2</i> gene) at positions -986 (rs17514136), -602 (rs3124953), and -4 (rs3124952) with dental caries Polish children. Two hundred sixty Caucasian children aged 15 years were enrolled study: 82 “higher” experience (DMFT >5) 178 “lower” ≤5). In addition, subjects ≥1) caries-free = 0) compared. <i>FCN2 </i>SNPs genotyped PCR-RFLP...
The aim of the present study was to analyze association TLR2 (Toll-like receptor 2 gene) 2258G>A (rs5743708), TLR4 4 896A>G (rs4986790), and 1196C>T (rs4986791) polymorphisms with dental caries in Polish children. participants, 261 15-year-old children, were divided into two groups: 82 cases (i.e., children DMFT (Decayed, Missing, Filled Teeth) index >5, having either moderate or high experience, assigned as "higher" experience group) 179 controls ≤ 5, low very "lower" group). Genomic DNA...
The aim of the study was to examine frequencies genotypes and alleles <i>ACE</i> insertion/deletion (I/D) polymorphism their association with dental caries in a sample Polish children. subjects were 120 children experience (cases) 41 caries-free individuals (controls). genotyping performed using polymerase chain reaction. genotype distributions <i>ACE </i>I/D not statistically different between carious control However, we found borderline overrepresentation II + ID...
ABSTRACTThe aim of this review was to present and discuss current views on the treatment condylar fractures (CFs). The authors addressed following issues: etiology, epidemiology mechanisms CFs; strategies methods for CFs. Moreover, choice surgical approach open CFs as well techniques materials used fixation CF are discussed.The PubMed database search relevant articles published between 2000 2018. analysis referred both original papers (including meta-analyses) that concerned adult patients....
To examine the association of four FCN1 SNPs: -542G>A (rs10120023), -144C>A (rs10117466), +6658C>T (rs148649884), and +7895A>G (rs150625869) with dental caries in Polish children.The study group consisted 261 15-year-old teenagers: 82 children "higher" experience (having Decayed Missing Filled Teeth, DMFT >5) 179 "lower" ≤5). Moreover, additional comparison, a 229 (DMFT ≥1) was compared to caries-free =0) 32 children. Extraction genomic DNA performed from buccal swabs, genotyping by...