A5050970796- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- melanin and skin pigmentation
- T-cell and Retrovirus Studies
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Mast cells and histamine
- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Digital Imaging for Blood Diseases
- Enterobacteriaceae and Cronobacter Research
- Genomics and Phylogenetic Studies
- Ocular Diseases and Behçet’s Syndrome
- Dental Health and Care Utilization
- Biochemical Analysis and Sensing Techniques
- Syphilis Diagnosis and Treatment
- Research on Leishmaniasis Studies
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Parasites and Host Interactions
- Vasculitis and related conditions
Pontifícia Universidade Católica do Paraná
2016-2025
Santa Casa de Misericórdia de Passos
2022
Centro Universitário Curitiba
2021
Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas
2016
Fundação de Medicina Tropical
2015
Universidade Federal da Bahia
2015
Pontifícia Universidade Católica de São Paulo
2010
St. Luke's-Roosevelt Hospital Center
2009
Columbia University
2009
Universidade Federal do Paraná
2009
Oral Diseases (2010) 16, 613–623 Dental decay is a complex, chronic disease and one of the most common illnesses in dentistry today. Several dental risk factors have been identified during last years; however, these variables alone may not entirely explain development. Genetic research applied to began 1930s with experimental reports animals human observational research. Only recently, some studies begun search for genetic polymorphisms humans apply linkage analysis. However, due complex...
In leprosy, type 1 reaction (T1R) and 2 (T2R) are major causes of nerve injury permanent disabilities. A previous study on plasma levels 27 cytokines in patients with T1R or T2R controls nonreactional leprosy identified the gene for interleukin 6 (IL-6) as a candidate genetic analysis. Two nested case-control studies were built from cohort 409 central Brazil, monitored T2R. There was evidence association between IL-6 tag single-nucleotide polymorphisms rs2069832 (P = .002), rs2069840 .03),...
Abstract Background Leprosy has been treated with multidrug therapy, which distributed for free across the globe and regarded as highly efficient. However, impossibility of growing Mycobacterium leprae in axenic media historically impaired assessments M. resistance, a parameter only recently detectable through molecular methods. Methods A systematic, population-based search resistance suspected leprosy relapse cases contacts was performed Prata Village, an isolated, hyperendemic, former...
Conflicting findings about the association between leprosy and TLR1 variants N248S I602S have been reported. Here, we performed case-control family based studies, followed by replication in 2 populations from Brazil, involving 3162 individuals. Results indicated an 248S study (SS genotype odds ratio [OR], 1.81; P = .004) (z 2.02; .05). This was consistently replicated other (combined OR, 1.51; < .001), corroborating finding that is a susceptibility factor for leprosy. Additionally,...
Leprosy, a chronic infectious disease caused mainly by Mycobacterium leprae (M. leprae), is still an important public health problem in countries such as Brazil and India. Here, we estimate key epidemiological parameters the Prata Village, unique, hyper-endemic, former leprosy colony isolated Brazilian Amazon. This population-based study which entire Village population has been enrolled. Clinical, socioeconomic, demographic data were obtained validated cross-checking using three independent...
Previous studies have demonstrated the association between occurrence of leprosy and several host genetic variants that can vary across different ethnic groups populations. Since susceptibility genes not been investigated in detail Bangladeshi population still includes highly endemic areas, we here studied known associations 13 markers located 11 a area Bangladesh for which an with was previously found isolated former colony Brazilian Amazon. For this study, family-based analysis using 60...
Chronic kidney disease (CKD) and periodontitis (PD) are serious public-health concerns. Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate variety of biological processes, such as bone metabolism, immune response modulation transcription several genes involved in CKD PD mechanisms. The aim this work was investigate the association between polymorphisms VDR gene end-stage renal (ESRD) PD.222 subjects without ESRD (in hemodialysis) were...
Although awareness of the relevance leprosy and human immunodeficiency virus (HIV) coinfection is increasing worldwide, several aspects this co-occurrence are not fully understood.We describe clinical, pathological, immunological, therapeutic long-term follow-up a cohort 25 individuals with HIV infection from Manaus, Amazonas.Careful description our indicates higher prevalence in an HIV-positive population than that general population. We also observed upgrading shifting clinical forms after...
Leprosy is a chronic infectious disease that affects 250,000 new individuals/year worldwide. Genetic analysis has been successfully applied to the identification of host genetic factors affecting susceptibility leprosy; however, consensus regarding its mode inheritance yet be achieved.We conducted complex segregation (CSA) on leprosy using data from Prata Colony, an isolated, highly endemic former community located at outskirts Brazilian Amazon. The colony offers large multiplex,...
The species Phytobacter diazotrophicus and the associated genus were originally described by Zhanget al. [Arch Microbiol189 (2008), 431-439] on basis of few endophytic nitrogen-fixing bacteria isolated from wild rice (Oryza rufipogon) in China. In this study, we demonstrate that a number clinical isolates either literature, preserved culture collections, or obtained during 2013 multi-state sepsis outbreak Brazil also belong to same genus. 16S rRNA gene sequencing, multilocus sequence...
Host genetic susceptibility to leprosy has been intensively investigated over the last decades; however, there are no studies on role of variants in disease recurrence. A previous initiative identified three recurrent cases for which none M. leprae strains, as obtained first and second diagnosis, had any known genomic associated resistance Multidrug therapy; addition, whole genome sequencing indicated that same was causing two out recurrences. Thus, these individuals were suspected being...