A5062743464- Leprosy Research and Treatment
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Engineering and Materials Science Studies
- Mosquito-borne diseases and control
- Data-Driven Disease Surveillance
- Electric and Hybrid Vehicle Technologies
- Zoonotic diseases and public health
- Health, Nursing, Elderly Care
- Ocular Diseases and Behçet’s Syndrome
- Digital Imaging for Blood Diseases
- Hematological disorders and diagnostics
- Psoriasis: Treatment and Pathogenesis
- Dermatological diseases and infestations
- Autoimmune and Inflammatory Disorders
- Malaria Research and Control
- Health, Education, and Cultural Studies
- Mathematical and Theoretical Epidemiology and Ecology Models
- Evolution and Genetic Dynamics
- HIV/AIDS Impact and Responses
- Acne and Rosacea Treatments and Effects
- Autism Spectrum Disorder Research
Universidade Federal Fluminense
2014-2024
London School of Hygiene & Tropical Medicine
2020-2024
University of Glasgow
2024
Departamento de Epidemiología
2017-2021
Hospital Universitário Antônio Pedro
2021
Instituto de Saúde
2013-2020
Fundação Oswaldo Cruz
2003-2020
Integra (United States)
2020
Fundação Saúde
2020
Universidade Federal da Bahia
2020
Although leprosy is recognised as a disease of poverty, there little evidence on the specific socioeconomic factors associated with risk. To inform targeted strategies for elimination, we investigated markers risk in Brazil.
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Background Social determinants can affect the transmission of leprosy and its progression to disease. Not much is known about effectiveness welfare primary health care policies on reduction occurrence. The aim this study evaluate impact Brazilian cash transfer (Bolsa Família Program-BFP) (Family Health Program-FHP) programs new case detection rate leprosy. Methodology/Principal Findings We conducted with a mixed ecological design, combination an multiple-group time-trend design in period...
Background The elimination strategy reduced known leprosy prevalence but the detection rate remains high in many countries, including Brazil. Brazilian imposes a limit to reduction of short term. knowledge time behaviour and spatial distribution statistics will contribute decision making for control. Method numbers newly diagnosed cases by region year from 1980 2004, prevalent 1990 2007 were fitted as parabolic function negative binomial regression models. To detect areas with increased...
Treatment default is a serious problem in tuberculosis control because it implies persistence of infection source, increased mortality, relapse rates and facilitates the development resistant strains.This study analyzed treatment determinants Amazonas State to contribute planning appropriate interventions.Observational with retrospective cohort using Brazilian Disease Notification System data from 2005 2010. A nested case design was used. Patients defaulting were considered as 'cases' those...
To evaluate the impact of Brazilian cash transfer programme (Bolsa Família Programme, BFP) on tuberculosis (TB) incidence in Brazil from 2004 to 2012.We studied surveillance data using a combination an ecological multiple-group and time-trend design covering 2458 municipalities. The main independent variable was BFP coverage outcome TB rate. All study variables were obtained national databases. We used fixed-effects negative binomial models for panel adjusted selected covariates representing...
Background Leprosy control is based on early diagnosis and multidrug therapy. For treatment purposes, leprosy patients can be classified as paucibacillary (PB) or multibacillary (MB), according to the number of skin lesions. Studies regarding a uniform regimen (U-MDT) for all have been encouraged by WHO, rendering disease classification unnecessary. Methodology findings An independent, randomized, controlled clinical trial conducted from 2007 2015 in Brazil, compared main outcomes (frequency...
Dermatological diseases are among the primary causes of demand for basic health care. Studies on frequency dermatoses important proper management planning.
To detect areas with increased case-detection rates, we used spatial scan statistics to identify 5 of 10 clusters leprosy in the Amazon region Brazil. Despite increasing economic development, population growth, and road infrastructure, is endemic this region, which a source case exportation other parts
Since leprosy is both treated and controlled by multidrug therapy (MDT) it important to monitor recurrent cases for drug resistance distinguish between relapse reinfection as a means of assessing therapeutic efficacy. All three objectives can be reached with single nucleotide resolution using next generation sequencing bioinformatics analysis Mycobacterium leprae DNA present in human skin.DNA was isolated optimized extraction enrichment methods from samples patients participating an...
Despite progress toward reducing global incidence, leprosy control remains a challenge in low- and middle-income countries.To estimate new case detection rates of among household contacts patients with previously diagnosed to investigate its associated risk factors.This population-based cohort study included families registered the 100 Million Brazilian Cohort linked nationwide registries leprosy; data were collected from January 1, 2007, through December 31, 2014. Household previous...
Indirect financial costs and barriers to health-care access might contribute leprosy treatment non-adherence. We estimated the association of Brazilian conditional cash transfer programme, Programa Bolsa Família (PBF), on adherence cure in patients Brazil.
To evaluate the risk factors related to worsening of physical disabilities after treatment discharge among patients with leprosy administered 12 consecutive monthly doses multidrug therapy (MDT/WHO).Cohort study was carried out at Leprosy Laboratory in Rio de Janeiro, Brazil. We evaluated multibacillary treated (MDT/WHO) between 1997 and 2007. The Cox proportional hazards model used estimate relationship onset release from epidemiological clinical characteristics.The total observation time...
Background Leprosy reactions, reversal reactions/RR and erythema nodosum leprosum/ENL, can cause irreversible nerve damage, handicaps deformities. The study of Mycobacterium leprae-specific serologic responses at diagnosis in the cohort patients enrolled Clinical Trial for Uniform Multidrug Therapy Regimen Patients Brazil/U-MDT/CT-BR is suitable to evaluate its prognostic value development reactions. Methodology IgM IgG antibody PGL-I, LID-1, ND-O-LID were evaluated by ELISA 452...
Although leprosy is largely curable with multidrug therapy, incomplete treatment limits therapeutic effectiveness and an important obstacle to disease control. To inform efforts improve completion rates, we aimed identify the geographic socioeconomic factors associated default in Brazil.
Abstract Background Leprosy continues to be an important cause of physical disability in endemic countries such as Brazil. Knowledge determinants these events may lead better control measures and targeted interventions mitigate its impact on affected individuals. This study investigated factors among the most vulnerable portion Brazilian population. Methods A large cohort was built from secondary data originated a national registry applicants social benefit programs, covering period...
Host genetic susceptibility to leprosy has been intensively investigated over the last decades; however, there are no studies on role of variants in disease recurrence. A previous initiative identified three recurrent cases for which none M. leprae strains, as obtained first and second diagnosis, had any known genomic associated resistance Multidrug therapy; addition, whole genome sequencing indicated that same was causing two out recurrences. Thus, these individuals were suspected being...
Background Leprosy remains concentrated among the poorest communities in low-and middle-income countries and it is one of primary infectious causes disability. Although there have been increasing advances leprosy surveillance worldwide, underreporting still common can hinder decision-making regarding distribution financial health resources thereby limit effectiveness interventions. In this study, we estimated proportion unreported cases Brazilian microregions. Methodology/Principal findings...
Leprosy reactions (LR) are severe episodes of intense activation the host inflammatory response uncertain etiology, today leading cause permanent nerve damage in leprosy patients. Several genetic and non-genetic risk factors for LR have been described; however, there limited attempts to combine this information estimate a patient developing LR. Here we present an artificial intelligence (AI)-based system that can assess using clinical, demographic, data. The study includes four datasets from...
Leprosy is a neglected tropical disease predominately affecting poor and marginalized populations. To test the hypothesis that poverty-alleviating policies might be associated with reduced leprosy incidence, we evaluated association between Brazilian Bolsa Familia (BFP) conditional cash transfer program new case detection using linked records from 12,949,730 families in 100 Million Cohort (2007-2014). After propensity score matching BFP beneficiary to nonbeneficiary families, used...
Leprosy is a neglected dermato-neurologic, infectious disease caused by Mycobacterium leprae or M. lepromatosis. treatable and curable multidrug therapy/MDT, consisting of 12 months rifampicin, dapsone clofazimine for multibacillary/MB patients 6 paucibacillary/PB patients. The relapse rate considered crucial treatment outcome. A randomized Controlled Clinical Trial (U-MDT/CT-BR) conducted from 2007‒2012 compared clinical outcomes in MB after regular MDT/R-MDT uniform MDT/U-MDT two highly...
Este artigo problematiza a estratégia tradicional de controle do Aedes aegypti por meio trabalho guardas sanitários, com visitas periódicas todas as edificações urbanas. Ela não é viável e/ou tem factibilidade administrativa atualmente, já que vem sendo proposta desde década 80 e implementada. A reforma sanitária brasileira priorizou ampliação da cobertura dos serviços básicos saúde ações doenças específicas. O A. reintroduzido para iniciar reocupação seu antigo habitat em 1976, está...