A5073185356- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Anesthesia and Pain Management
- Immune Response and Inflammation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Growth Hormone and Insulin-like Growth Factors
- Erythrocyte Function and Pathophysiology
- Cancer, Stress, Anesthesia, and Immune Response
- Nausea and vomiting management
- Cancer Research and Treatments
- interferon and immune responses
- Global Cancer Incidence and Screening
- Circadian rhythm and melatonin
- Blood disorders and treatments
- Migration, Aging, and Tourism Studies
- Cancer Diagnosis and Treatment
- Pediatric Pain Management Techniques
- Women's cancer prevention and management
- Nerve Injury and Rehabilitation
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Psoriasis: Treatment and Pathogenesis
Universidade Federal de Alagoas
2019-2024
Centre for Health Technology and Services Research
2023-2024
University of Aveiro
2023
Iscte – Instituto Universitário de Lisboa
2023
Fundação Oswaldo Cruz
2011-2021
Conflicting findings about the association between leprosy and TLR1 variants N248S I602S have been reported. Here, we performed case-control family based studies, followed by replication in 2 populations from Brazil, involving 3162 individuals. Results indicated an 248S study (SS genotype odds ratio [OR], 1.81; P = .004) (z 2.02; .05). This was consistently replicated other (combined OR, 1.51; < .001), corroborating finding that is a susceptibility factor for leprosy. Additionally,...
The pathways that trigger exacerbated immune reactions in leprosy could be determined by genetic variations. Here, a prospective approach, both and non-genetic variables influencing the amount of time before development reactional episodes were studied using Kaplan-Meier survival curves, effect was estimated Cox proportional-hazards regression model. In sample including 447 patients, we confirmed gender (male), high bacillary clinical forms are risk factors for reactions. From 15 single...
Leprosy Type-1 Reactions (T1Rs) are pathological inflammatory responses that afflict a sub-group of leprosy patients and result in peripheral nerve damage. Here, we employed family-based GWAS 221 families with 229 T1R-affect offspring stepwise replication to identify risk factors for T1R. We discovered, replicated validated T1R-specific associations SNPs located chromosome region 10p21.2. Combined analysis across the three independent samples resulted strong evidence association rs1875147...
Mycobacterium leprae infects macrophages and Schwann cells inducing a gene expression program to facilitate its replication progression disease. MicroRNAs (miRNAs) are key regulators of could be involved during the infection. To address genetic influence miRNAs in leprosy, we enrolled 1,098 individuals conducted case-control analysis order study four genes containing single nucleotide polymorphism (miRSNP). We tested miRSNP-125a (rs12975333 G>T), miRSNP-223 (rs34952329 *>T), miRSNP-196a-2...
A current major challenge in leprosy control is the prevention of permanent disabilities. Host pathological inflammatory responses termed type-1 reaction (T1R) are a leading cause nerve damage for patients. The environmental or inherited factors that predispose cases to undergo T1R not known. However, studies have shown an important contribution host genetics susceptibility T1R. We previously identified variants encompassing TNFSF15/TNFSF8 genes as T1R-risk Vietnamese sample and replicated...
// Victor Menezes Silva 1 , Jessica Alves Gomes Liliane Patrícia Gonçalves Tenório Genilda Castro de Omena Neta Karen da Costa Paixão Ana Kelly Fernandes Duarte Gabriel Cerqueira Braz Ricardo Jansen Santos Ferreira Bruna Del Vechio Koike 2 Carolinne Sales Marques Rafael Danyllo Miguel Aline Cavalcanti Queiroz Luciana Xavier Pereira and Carlos Alberto Carvalho Fraga Department of Medicine, Federal University Alagoas, Campus Arapiraca, Brazil the São Francisco Valley, Petrolina, Correspondence...
The COVID-19 pandemic had a major impact on aged care services. In Portugal, social workers are key frontline professionals in A photovoice program called "Eyes the Pandemic" was carried out to capture internal experiences of working services during first year pandemic. Photovoice is qualitative, participatory action-research method which participants share their lives through photographs and narratives (voices) presented discussed with others. Thirteen between 24 41 years old participated....
INTRODUCTION: Leprosy is a chronic infectious disease caused by Mycobacterium leprae.This study aimed to analyze the epidemiological, temporal, and spatial dynamics ofleprosy in municipality northeastern Brazil. METHODS: This an ecological on new leprosy cases population of Arapiraca (Alagoas, Northeast Region, Brazil), from 2008 2017. Data extracted national database were analyzed forepidemiological indicators, factors associated with physical disabilities, spatialanalysis neighborhoods...
African ancestry seems to be a risk factor for hypertension; however, few genetic studies have addressed this issue. This study aimed investigate the prevalence of polymorphisms NOS3; rs1799983, IGFBP3; rs11977526 and TCF7L2; rs7903146 in Brazilian women descent their association with hypertension. The prevalences less frequent genotypes were 26.5% TT genotype 16.7% AA rs11977526, 18.3% rs7903146. For these conditions, hypertension PR (adjusted) relatively ancestral were, respectively: 52.0%...
Introdução: A COVID-19 (coronavirus disease 2019) trouxe inúmeros desafios e sobrecarga ao Sistema Único de Saúde (SUS), gerando dificuldades no enfrentamento das outras enfermidades endêmicas negligenciadas território brasileiro, entre elas a hanseníase. Objetivo: Relatar experiência da prevalência oculta hanseníase por uma equipe atenção primária à saúde do interior estado Sergipe durante pandemia COVID-19. Métodos: O projeto foi desenvolvido os meses setembro 2020 janeiro 2021...
Breast cancer is the most common malignant neoplasm in women worldwide. Surgery has been traditional treatment and, generally, it´s mastectomy with lymphadenectomy, that can causes postoperative pain. Therefore, we seek to study regional anesthesic techniques minimize this effect, such as interpectoral block (PECS).randomized controlled 82 patients breast who underwent lymphadenectomy from January 2020 October 2021 oncology hospital.two randomized groups (control - exclusive general...
<title>Abstract</title> The increase in cancer incidence and mortality worldwide has demonstrated the need for investment more effective anti-tumor therapies. Given complexity of mechanisms that lead to resistance treatments, target therapies are promising approaches. Cancer testicular antigens (CTAs) therapeutic targets with potential be explored, as they not expressed normal cells tumor cells, is case TFDP3, triple-negative breast cancer, prostate childhood T-cell lymphoblastic leukemia...
Primary tumors can precondition a pre-metastatic niche, promoting the colonization of circulating neoplastic cells and influencing secondary tumor microenvironment. Nevertheless, mechanisms underlying formation this as well perineural invasion in oral squamous cell carcinoma (OSCC), are not well-elucidated. The study aims to identify differentially expressed genes (DEGs) related pathways associated with niche OSCC. We evaluated metastatic non-metastatic primary samples, healthy tissues, OSCC...
Leprosy is a chronic infectious disease, with genetics fundamentally responsible for its outcome. Single nucleotide polymorphisms (SNPs) in immune response genes have been shown to participate the disease. Human Toll-like receptor 1 (TLR1) leprosy infection recognizes cell wall components and activates immunological responses, TLR1 may control disease progression. Studies investigating SNPs not reached consensus. We performed meta-analysis evaluate participation of infection. For that...
BACKGROUND: Breast cancer is a common neoplasm in women worldwide. Its varying patterns of incidence and clinical prognosis Brazil make it an important complex public health problem that needs to be solved. OBJECTIVES: To analyze the temporal dynamics hospital admissions deaths due female breast state Alagoas, Brazil, from 2009 2019. DESIGN AND SETTING: Cross-sectional study including secondary data Alagoas. METHODS: A joinpoint regression model was constructed for analysis over this period....