A5075621071- Inflammatory Bowel Disease
- Microscopic Colitis
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Pituitary Gland Disorders and Treatments
- Celiac Disease Research and Management
- Glioma Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Polyomavirus and related diseases
- Renal Transplantation Outcomes and Treatments
- Myasthenia Gravis and Thymoma
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal motility and disorders
- Intestinal and Peritoneal Adhesions
- Adrenal and Paraganglionic Tumors
- Metabolism and Genetic Disorders
- Nutrition and Health Studies
- Adipose Tissue and Metabolism
- Congenital gastrointestinal and neural anomalies
Children's Memorial Health Institute
2015-2024
Medical University of Warsaw
2011-2020
Instytut Matki i Dziecka
2017
University of Łódź
2007-2011
The progression of non-alcoholic fatty liver (NAFL) into steatohepatitis implicates multiple mechanisms, chief which is mitochondrial dysfunction. However, the sequence events underlying failure are still poorly clarified. In this work, male C57BL/6J mice were fed with a high-fat plus high-sucrose diet for 16, 20, 22, and 24 weeks to induce NAFL. Up 20th week, an early remodeling increased OXPHOS subunits levels higher respiration occurred. Interestingly, progressive loss along “Western...
Non-alcoholic fatty liver disease (NAFLD) is a health concern affecting 24% of the population worldwide. Although pathophysiologic mechanisms underlying are not fully clarified, mitochondrial dysfunction and oxidative stress key players in progression. Consequently, efforts to develop more efficient pharmacologic strategies targeting mitochondria for NAFLD prevention/treatment underway. The conjugation caffeic acid anti-oxidant moiety with an alkyl linker triphenylphosphonium cation (TPP+),...
To assess the clinical efficacy and impact of infliximab (IFX) induction therapy on mucosal healing in Polish children with Crohn's disease (CD).A total 66 (29 boys 37 girls) aged 14.06 ± 3.59 years CD diagnosed at mean age 8.4 7.3 were included study. Patients received IFX (5 mg/kg) three repeated infusions 0, 2, 6 weeks. The activity was assessed using Pediatric Disease Activity Index (PCDAI) endoscopic scored Simple Endoscopic Score for baseline week 10.Twenty-two (33%) studied patients...
Nonalcoholic fatty liver disease (NAFLD) is characterized by the development of steatosis, which can ultimately compromise function. Mitochondria are key players in obesity-induced metabolic disorders; however, distinct role hypercaloric diet constituents hepatic cellular oxidative stress and metabolism unknown. Male mice were fed either a high-fat (HF) diet, high-sucrose (HS) or combined HF plus HS (HFHS) for 16 weeks. This study shows that diets caused steatosis; HFHS induced severe...
The aim of this study was to assess the long-term results liver transplantation (LT) in pediatric patients with unresectable hepatoblastoma (HB) or hepatocellular carcinoma (HCC) special reference risk tumor recurrence. We retrospectively analyzed data from 46 HB and 26 HCC who underwent LT between 1990 2022. In patients, we compared outcomes depending on donor type. evaluated impact a number factors recurrence-free survival after LT. Estimated patient 5, 10, 15 years 82%, 73%, 73% group...
In Wilson disease (WD), liver copper (Cu) excess, caused by mutations in the ATPase Cu transporting beta (ATP7B), has been extensively studied. contrast, gastrointestinal tract, responsible for dietary uptake, ATP7B malfunction is poorly explored. We therefore investigated gut biopsies from WD patients and compared intestines two rodent models human knock-out intestinal cells to their respective wild-type controls. observed (GI) inflammation patients, rats mice lacking ATP7B. Mitochondrial...
Tuberous sclerosis complex (TSC) is associated with a high risk of early-onset epilepsy and developmental delay. Recently, EEG monitoring in infants TSC preventive antiepileptogenic treatment have been proposed to improve neurodevelopmental outcome. We explored how recent studies recommendations regarding influenced the clinical practice management among children TSC.MethodsA survey on approach was sent by e-mail 165 clinicians who actively participated international research conferences...
Abstract: An atypical type A thymoma is a newly added entity to the last World Health Organization (WHO) histological classification [2015] of uncertain prognosis. The conventional and AB thymomas are usually locally aggressive neoplasms that rarely metastasize with distant metastases central nervous system (CNS) occurring extremely exceptionally. We present history woman mediastinal tumor originally considered be Masaoka-Koga stage II "mixed well-differentiated thymic carcinoma component"...
BACKGROUND:The aim of this study was to find the main risk factors for development cardiac allograft vasculopathy (CAV), especially identified before surgical procedure and related recipient profile medical history donor. MATERIAL AND METHODS:There were 147 patients who had heart transplantation (HT) included in study: mean age 45.8±15.3 years. All coronary angiography after HT. Analyzed were: non-immunologic (age transplantation, smoking, hypertension, lipids, diabetes, obesity weight gain...
Disruption of epithelial junctional complex (EJC), especially tight junctions (TJ), resulting in increased intestinal permeability, is supposed to activate the enhanced immune response gluten and induce development celiac disease (CD). This study aimed present role EJC CD pathogenesis. To analyze differentially expressed genes next-generation mRNA sequencing data from CD326+ cells isolated non-celiac patients were involved. Ultrastructural studies with morphometry done potential CD, newly...
BACKGROUND:Liver transplantation (LT) is recommended for various metabolic diseases, including urea cycle disorders (UCDs). The aim of this study was to determine indications and outcomes LT UCDs in the tertiary reference Children's Hospital Warsaw, Poland. MATERIAL AND METHODS:Medical charts children with UCD who underwent between 2008 July 2016 were retrospectively reviewed. following parameters analyzed: symptoms at time diagnosis, age transplantation, graft characteristics survival,...
Ectopic adrenocorticotropic syndrome (EAS) causes approximately 10-18% of cases Cushing's (CS) in adults, while children it occurs much less frequently.We report two neuroendocrine tumors (of the thymus and appendix) a 12-year-old boy 15-year-old girl who presented with clinical features CS. Elevated serum cortisol, ACTH, chromogranin levels were observed both patients. Diagnoses made on basis mass thymus/appendix region visualized chest/abdominal CT scan radiotracer accumulation...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Cielecka-Kuszyk J, Lipiński P, Szymańska S, Ismail H, Jankowska I. Long-term follow-up in children with progressive familial intrahepatic cholestasis type 2 after partial external biliary diversion focus on histopathological features. Polish Journal of Pathology. 2019;70(2):79-83. doi:10.5114/pjp.2019.87099. APA Cielecka-Kuszyk, J., Lipiński, P., Szymańska, S., Ismail, H., & Jankowska, (2019). Pathology, 70(2),...
Abstract Purpose Craniopharyngioma is one of the most frequent benign tumours central nervous system in paediatric population. Although it a tumour according to WHO classification, significantly deteriorates patient’s quality life. The aim this study assess if proliferation index Ki67 can be useful marker risk craniopharyngioma’s recurrence. Methods Expression was examined 85 specimens primary craniopharyngioma and 11 recurring tumour. In all cases, adamantinomatous type diagnosed. Values...
BACKGROUND:The International Society for Heart and Lung Transplantation (ISHLT) has recently proposed a new protocol reporting pathologic diagnosis of antibody-mediated rejection (pAMR). The criteria precisely defined antibody panels morphologic features indicative AMR. aim this study was to reclassify endomyocardial biopsy specimens (EMBs) that had previously been classified as C4d-positive (AMR1) according the former ISHLT 2004 verify whether new, stricter have any impact on number AMR...
AMA Szymanska S, Rokicki D, Karkucinska-Wieckowska A, et al. Case report of an adolescent girl with limb-girdle muscular dystrophy type 2B – the usefulness muscle protein immunostaining in diagnosis dysferlinopathies. Folia Neuropathologica. 2014;52(4):452-456. doi:10.5114/fn.2014.47847. APA Szymanska, S., Rokicki, D., Karkucinska-Wieckowska, A., Szymanska-Debinska, T., Ciara, E., & Ploski, R. (2014). Neuropathologica, 52(4), 452-456. https://doi.org/10.5114/fn.2014.47847 Chicago Sylwia,...
Virginal breast hypertrophy is a multidisciplinary condition including surgical, pediatric, and endocrine/gynecological disciplines, its successful diagnosis management requires complex, team approach.
The significance of the Quilty effect (QE) is not fully understood. It was once proposed to be related acute cellular rejection (ACR). We aim assess relation between QE prevalence and antibody-mediated (AMR). One thousand three hundred fifty endomyocardial biopsies (EMBs) from 212 patients who underwent heart transplantation in years 2001-2013 survived a period 30 days after operation were diagnosed. In all EMBs routine HE staining additional immunohistochemical with polyclonal antibody...
Inflammatory bowel disease (IBD), which includes Crohn's (CD) and ulcerative colitis (UC), is a chronic condition of the colon small intestine. The common in young people (children adults), but it rare children younger than five years age. Therefore, IBD developing during first life (under age 5) known as an early-onset (EO-IBD), considered to be specific entity with distinct phenotype. However, available data on that issue are still insufficient.To determine characteristics clinical course...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kierkus J, Dądalski M, Szymanska S, et al. Maintenance therapy with infliximab for paediatric Crohn’s disease: impact on clinical remission and mucosal healing in Polish patients severe disease. Gastroenterology Review/Przegląd Gastroenterologiczny. 2012;7(1):26-30. doi:10.5114/pg.2012.27219. APA Kierkus, J., Dądalski, M., Szymanska, S., E., Wegner, A., & Górczewska, M. (2012). Gastroenterologiczny, 7(1),...