A5066151575- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Eosinophilic Disorders and Syndromes
- Kruppel-like factors research
- Lymphatic System and Diseases
- Erythropoietin and Anemia Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myocardial Infarction Research
- Chronic Myeloid Leukemia Treatments
- Systemic Sclerosis and Related Diseases
- Inflammatory mediators and NSAID effects
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Health and Disease Prevention
- Diabetes Treatment and Management
- Apelin-related biomedical research
- Platelet Disorders and Treatments
- Parathyroid Disorders and Treatments
- Nutrition, Genetics, and Disease
- Myofascial pain diagnosis and treatment
- Analytical Methods in Pharmaceuticals
- Diabetic Foot Ulcer Assessment and Management
- Hemophilia Treatment and Research
Collegium Medicum in Bydgoszcz
2014-2024
Nicolaus Copernicus University
2014-2024
GTx (United States)
2021
Morning increase in the occurrence of myocardial infarction, stroke and sudden cardiac death is a well-recognized phenomenon, which line with morning enhancement platelet aggregation. We investigated whether inhibition during clopidogrel aspirin therapy varies day. Fifty-nine consecutive patients (45 men 14 women) first ST-segment elevation infarction (STEMI) treated primary percutaneous coronary interventions (pPCI) on dual antiplatelet were prospectively enrolled into study. Blood samples...
AMA Żekanowska E, Boinska J, Giemza-Kucharska P, Kwapisz J. REVIEW PAPERObesity and iron metabolism. BioTechnologia. 2011;92(2):147-152. doi:10.5114/bta.2011.46528. APA Żekanowska, E., Boinska, J., Giemza-Kucharska, P., & Kwapisz, (2011). BioTechnologia, 92(2), 147-152. https://doi.org/10.5114/bta.2011.46528 Chicago Ewa, Joanna Paulina Justyna Kwapisz. 2011. "REVIEW metabolism". BioTechnologia 92 (2): Harvard pp.147-152. MLA Ewa et al. metabolism." vol. 92, no. 2, 2011, pp. Vancouver
Serum prohepcidin and other iron metabolism parameters... 105INTROduCTION Anemia of chronic disease (ACD) iron-deficiency anemia (IDA) are common hematological conditions present in elderly patients. [1]2][3] They a risk factor for cardiovascular diseases, contribute to fatigue, negatively affect cognitive physical functions as well the quality life. 4ACD is typically micro-or normocytic, normochromic associated with infections, noninfectious inflammatory malignancies.The pathogenesis ACD...
Introduction: In patients with diabetic foot syndrome (DFS), an inadequate angiogenic response is observed. The aim of this study was to evaluate the concentrations VEGF-A, PDGF-BB, sVEGF-R2 and sVEGF-R1 in diabetes-complicated analyse them using selected clinical data. Material methods: Forty seven patients, 25 women mean age 63 20 men 60.5, (DFS) were enrolled experimental group. To angiogenesis factors depending on Wagner grade, subjects divided into three subgroups: I — 0 grade (n = 14);...
Aim of this study was assessment the relationship between concentrations ticagrelor and its active metabolite (AR-C124910XX) results selected platelet function tests. In a single-centre, cohort study, patients with myocardial infarction underwent blood sampling following 180 mg loading dose intake (predose, 1, 2, 3, 4, 6, 12, 24 hours postdose) to perform pharmacokinetic pharmacodynamic assessments. Platelet reactivity evaluated using VASP-assay, VerifyNow device Multiplate analyzer....
To examine the impact of a body fat content on concentration serum prohepcidin, iron metabolism parameters and inflammation markers in elderly patients with microcytic or normocytic anemia.
INTRODUCTION The clinical course of essential thrombocythemia (ET) is varied, and some patients do not exhibit any signs the disease at time diagnosis. most frequent complications that occur during ET are hemostasis abnormalities manifesting as hemorrhagic or thrombotic events. mechanism events in with complex fully understood. OBJECTIVES aim study was to evaluate concentration activity tissue factor (TF) pathway inhibitor (TFPI), depending on important risk factors (age >60 years, history...
Hemostatic disorders are a major clinical problem in patients with myeloproliferative neoplasms (MPNs) and they the second most common cause of death MPN patients, after infections. The aim this study was to assess fibrinolytic potential blood MPNs. involved 112 MPNs diagnosed at Hematology Clinic Dr J. Biziel University Hospital No. 2 Bydgoszcz, Poland. group included 63 essential thrombocythemia, 29 polycythemia vera, 11 chronic myelogenous leukemia (CML) nine primary myelofibrosis....
Data from the literature indicate relationship between bone marrow microvessel density and blood parameters of angiogenesis. The aim this study was to evaluate selected angiogenesis (VEGF-A, sVEGFR-1, sVEGFR-2) their correlations with white cells, platelets, red cells.The included 72 patients (mean age, 61.84 years) myeloproliferative neoplasms (MPNs): essential thrombocythemia (ET) (n=46), polycythemia vera (PV) (n=19), primary myelofibrosis (PMF) (n=7). Serum VEGF-A, sVEGFR-2 were...
Recently, there is great interest in vasculogenesis, a process of the formation new blood vessels from progenitor cells or angioblasts, pathogenesis cancer. To best our knowledge, evaluation endothelial (EPCs) Hodgkin's lymphoma has not yet been reported. The aim present study was to assess number EPCs and selected cytokines, such as vascular growth factor (VEGF-A) stromal cell-derived (SDF-1α) involved vasculogenesis patients. conducted group 42 patients with (eight relapsed 34 before first...
A high number of blood donations may cause iron depletion. The pathophysiology behind this process involve hepcidin, a recently discovered peptide that acts by inhibiting absorption and promoting retention in reticuloendothelial macrophages. aim study was to determine serum pro-hepcidin levels metabolism parameters multi-time donors. group consisted 132 male donors 25 healthy volunteers (nondonors). Complete cell count status including iron, ferritin, soluble transferrin receptor (sTfR),...
Background and objectives: Recent studies suggest that a vascular endothelial growth factor (VEGF-A) may be involved in the thrombotic process by stimulating expression of tissue cells. Tissue (TF) can also stimulate transcription gene encoding VEGF-A. The relationship between coagulation angiogenesis myeloproliferative neoplasms is not fully understood. aim this study was to evaluate concentration TF relation VEGF-A blood patients with essential thrombocythemia (ET). Patients methods: group...
The aim of the study was to evaluate selected angiogenic factors in patients with essential thrombocythemia (ET) depending on JAK2V617F, calreticulin gene (CALR) and myeloproliferative leukemia virus oncogene (MPL) mutations. Sixty ET 20 healthy volunteers were enrolled study. following tests performed: vascular endothelial growth factor- A (VEGF-A), soluble factor receptor-1 (sVEGFR-1),soluble receptor-2 (sVEGFR-2), platelet-derived factor( PDGF-BB), stromal-derived factor-1α (SDF-1α). We...
The aim of the study was to evaluate diurnal changes tissue factor (TF) and pathway inhibitor (TFPI) concentrations in relation on-treatment platelet reactivity. group included 51 patients with acute myocardial infarction (AMI) treated primary percutaneous coronary intervention dual antiplatelet therapy. TF TFPI were assessed using enzyme-linked immunosorbent assay kits. We found a significant increase concentration clopidogrel-resistant, but not clopidogrel-sensitive, at 10.00 a.m. (410.66...
Thrombotic complications may occur in 7.6-29.4% of patients with essential thrombocythemia. According to the cellular theory, tissue factor (TF) activating extrinsic blood coagulation pathway is for activation clotting. The aim study was evaluate TF-dependent thrombocythemia, depending on presence or absence Janus kinase 2 (JAK2) V617F mutation. included 74 newly diagnosed (F/M: 47/27; mean age 61 years) thrombocythemia (Tefferi and Vardiman, Leukemia 2008; 22(1):14-22). Patients were...
Wstęp: Obecny stan wiedzy wskazuje na ścisły związek pomiędzy nadwagą czy otyłością a zaburzeniami metabolizmu żelaza. Jednakże mechanizmtej zależności nie jest wyjaśniony. Hepcydyna może być istotnym czynnikiem niedoborów żelaza obserwowanych w populacji osób otyłych. Materiał i metody: Badanie zrealizowano wśród 58 otyłych (K/M 34/24), wieku 65–91 lat (78,92 ± 8,32 lat). Grupę kontrolną stanowiło15 zdrowych ochotników z prawidłową masą ciała, dobranych odpowiednio pod względem płci. Na...
The hemojuvelin–hepcidin regulatory axis may play a key role in the iron metabolism both systemically and locally. There is pressing need to evaluate this tightly regulated network of parameters their potential impact on development ischemic stroke (IS). We aimed assess biomarkers patients after IS, evaluating changes over time considering clinical features. studied 45 diagnosed with IS. assessed major parameters, such as hepcidin, soluble hemojuvelin (sHJV), transferrin receptor (sTfR),...