A5058527033- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Lipoproteins and Cardiovascular Health
- Medication Adherence and Compliance
- Diabetes Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Substance Abuse Treatment and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Cardiac Health and Mental Health
- Coronary Interventions and Diagnostics
- Cardiovascular and Diving-Related Complications
- Metabolism, Diabetes, and Cancer
- Advanced Biosensing Techniques and Applications
- Inflammatory mediators and NSAID effects
- Congenital Heart Disease Studies
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Viral Infections and Immunology Research
- Cognitive Functions and Memory
- Gambling Behavior and Treatments
- Hydraulic and Pneumatic Systems
Nicolaus Copernicus University
2012-2024
Collegium Medicum in Bydgoszcz
2015-2024
Antoni Jurasz University Hospital
2015
The poor response to clopidogrel is multifactorial and includes, amongst others, low patient adherence medication. aim of this study was assess the reported treatment with confront it assessed by drug availability. We evaluated determinants its impact on platelet aggregation clinical outcome. population comprised 184 patients treated primary percutaneous coronary intervention for acute myocardial infarction. Follow-up visits were scheduled at 3, 6 9 months after discharge. Patient defined...
Ticagrelor is an oral platelet P2Y12 receptor antagonist which recommended for patients suffering from myocardial infarction, both with and without persistent ST segment elevation. Morphine the first choice drug in pain alleviation same clinical subset. Recently a possible negative influence of morphine on pharmacokinetics antiplatelet effects blockers has been postulated.The IMPRESSION study phase IV, single center, randomized, double-blind, placebo-controlled trial that designed to assess...
Background Data from available studies suggest that the presence of ST-elevation myocardial infarction (STEMI) may be associated with delayed and attenuated ticagrelor bioavailability effect compared non-ST-elevation (NSTEMI). Methods In a single-center, prospective, observational trial 73 patients (STEMI n = 49, NSTEMI 24) underwent pharmacokinetic pharmacodynamic assessment after 180 mg loading dose (LD). Ticagrelor its active metabolite (AR-C124910XX) plasma concentrations were determined...
Non-adherence rates to antiplatelet drugs in patients with acute myocardial infarction (AMI) range from 13% 60%. We aimed evaluate whether individual health education can improve adherence treatment clopidogrel after AMI. This was a prospective, single-center, randomized clinical trial 12-month follow-up. Patients AMI treated percutaneous coronary intervention (PCI) were enrolled. The primary endpoint defined as non-adherence during follow-up (drug availability ≤ 80%). Secondary endpoints...
Aim of this study was assessment the relationship between concentrations ticagrelor and its active metabolite (AR-C124910XX) results selected platelet function tests. In a single-centre, cohort study, patients with myocardial infarction underwent blood sampling following 180 mg loading dose intake (predose, 1, 2, 3, 4, 6, 12, 24 hours postdose) to perform pharmacokinetic pharmacodynamic assessments. Platelet reactivity evaluated using VASP-assay, VerifyNow device Multiplate analyzer....
Introduction: Poor medication adherence is associated with unsatisfactory health outcomes, elevated mortality, and high costs of medical care. This study aimed to assess the implementation therapeutic recommendations in cardiovascular-risk patients based on self-report questionnaires. Material methods: The included 194 from Cardiology Outpatient Clinic. Two self-reported questionnaires were used adherence: Medication Adherence Questionnaire (MAQ) Chronic Diseases Scale (ACDS). Results:...
Complex metabolic disorders associated with obesity and diabetes pose a serious therapeutic challenge. The DEMETER-SIRIO 11 study is phase III, multicenter, randomized, open-label, investigator-initiated clinical trial 6-month follow-up aimed at performing comparative evaluation of the effect two empagliflozin doses (10 mg vs. 20 mg) on selected parameters in patients syndrome. primary hypothesis that higher dose will result significant reduction BMI HbA1c MS receiving as compared to 10 mg....
Evidence suggests that both opioid addicted and gambling individuals are characterized by higher levels of risky behavior in comparison to healthy people. It has been shown the administration substitution drugs can reduce cravings for opioids decisions made opioids. Although it is suggested neurobiological foundations addiction similar, possible risk behaviors addicts may differ detail from those gambling. The aim this work was compare level opioid, with gambling, using Iowa Gambling Task...
Concomitant systemic essential hypertension (HTN) in adults with a secundum atrial septal defect (ASD) can unfavorably affect the hemodynamics and transcatheter ASD closure (ASDC) effects. This study aims to assess effectiveness safety of ASDC HTN real-world clinical practice. Right ventricular (RV) reverse remodeling (RVR) lack left-to-right interatrial residual shunt (NoRS) echocardiography 24 h 6 months (6 M) post-ASDC, ASDC-related complications within M were evaluated 184 adults: 79...
The main aim of this work was to determine the impact COMT and DRD2 gene polymorphisms together with temperament character traits on alcohol craving severity alcohol-dependent persons. sample comprised 89 men 16 women (aged 38±7). For sake psychological assessment various analytic methods have been applied like Short Alcohol Dependence Data Questionnaire (SADD), Penn Craving Scale (PACS) or Temperament Character Inventory (TCI) test. SNP polymorphism analyzed genes determined by Real Time...
According to the 2024 ESC guidelines for management of chronic coronary syndrome antianginal medical therapy aims control symptoms while ensuring acceptable tolerability and patient adherence. The specify indications particular groups drugs, defining class level evidence based on results expert opinions, registries, clinical studies, meta-analyses. This very important document has a great impact practice as it constitutes basis therapeutic decisions. Therefore, is worth understanding...
Oxidative stress plays a key role in the development of heart failure. The study is phase III, single-centre, randomized, double-blind, clinical trial that assesses influence early intravenous levosimendan administration patients with decompensated CHF on oxidative parameters and function enzymatic antioxidative mechanisms. A total 50 diagnosed reduced ejection fraction, LVEF ≤ 35% are randomized 1:1 ratio to receive either or dobutamine. hypothesis failure may reduce ROS production and/or...
Background. Many reports have demonstrated excessive variability in response to clopidogrel, the most commonly used P2Y12 receptor antagonist. Clopidogrel resistant patients are at increased risk of cardiovascular (CV) events. Prasugrel is a new inhibitor that provides greater and faster platelet inhibition reduces CV events more effectively than clopidogrel. The aim this study was evaluate efficacy prasugrel antiplatelet activity presenting with acute coronary syndrome (ACS). Materials...
Background. International guidelines recommend the use of cardiac troponin assays for early detection acute myocardial infarction. New high-sensitivity along with improved precision and sensitivity, are now widely available, accelerating patient’s diagnosis, treatment invasive therapy. In this study we evaluated analytical performance Abbott ARCHITECT STAT high-sensitive troponin-I immunoassay its 99th percentile upper reference limit. Methods. We performed evaluation hs-cTnI assay using...
Dobutamine and levosimendan are both indicated for inotropic support in acute decompensated heart failure (HF). The study aimed to assess the impact of early administration (first iv therapeutic approach) versus dobutamine on in-hospital treatment expenses clinical outcomes patients with chronic HF. ELEPHANT was designed as a phase III, multicentre, randomized 1:1, double-blind, active-controlled trial that will include admitted hospital due HF decompensation. Co-primary endpoints were...
Klopidogrel to jeden z leków stosowanych w leczeniu pacjentów ostrymi zespołami wieńcowymi. Jest on metabolizowany do aktywnego metabolitu, który jest nieodwracalnym antagonistą płytkowego receptora P2Y12 zależnego od adenozynodifosforanu. Odpowiedź farmakokinetyczna i farmakodynamiczna na klopidogrel osobniczo zmienna. W pracy przedstawiono przegląd badań służących ocenie związku czynników genetycznych ze skutecznością kliniczną klopidogrelu.
Introduction It is necessary to search for and carry out effective treatments chemical dependency – including behavioral addictions. One of the methods used in various disorders a biofeedback HRV (BF-HRV). The aim study examine impact BF-HRV on people addicted behaviorally gambling chemically dependent patients opioids. Material Twenty-four opioid addicts were examined. We emWave (HeartMath) with heart rhythm monitor learn stress reduction emotional management skills. For detailed analysis...
Methadone treatment may cause prolongation of QT/QTc. This study aims to assess the impact a single dose methadone on value QT in patients from substitution program. Participants: 37 people (10women and 27men) treated with The average age respondents was 35 ± 9 years old (min.21, max.59), mean time addiction 16 8 years, 80 18 ml. control group: 17 (6men 11women), healthy, non-addicted drugs. group 29 6 years. QTc (ECG) were measured automatically. performed before about 60minutes after...