A5010732325- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Cell death mechanisms and regulation
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Bone and Joint Diseases
- Lymphoma Diagnosis and Treatment
- Hematological disorders and diagnostics
- Bone and Dental Protein Studies
- Cancer-related Molecular Pathways
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Protein Degradation and Inhibitors
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
Copernicus Memorial Hospital
2016-2025
Medical University of Lodz
2016-2025
Semmelweis University
2023
Lublin Oncology Center
2023
Seoul St. Mary's Hospital
2023
Catholic University of Korea
2023
Universidad Autónoma de Bucaramanga
2023
Mansoura University
2023
Foscal Hospital
2023
Augusta Victoria Hospital
2023
Patients with primary refractory AML and early relapses have unfavorable prognoses require innovative therapeutic approaches. Purine analogs fludarabine (FA) cladribine (2-CdA) increase cytotoxic effect of Ara-C in leukemic blasts inhibit DNA repair mechanisms; therefore its association mitoxantrone (MIT) results a synergistic effect. In the current report, we present final multi-center phase II study evaluating efficacy toxicity CLAG-M salvage regimen poor risk refractory/relapsed...
Acute myeloid leukemia (AML) corresponds to a heterogeneous group of clonal hematopoietic diseases, which are characterized by uncontrolled proliferation malignant transformed precursors and their inability differentiate into mature blood cells. The prognosis AML depends on many variables, including the genetic features disease. Treatment outcomes, despite introduction new targeted therapies, still unsatisfactory. Recently, there have been an increasing number reports enzymatic proteins...
The circulating endothelial cells (CEC) are proposed to be a non-invasive marker of angiogenesis. level CEC in peripheral blood (PB) acute myeloid leukemia (AML) patients has not been investigated prior this study. We evaluated the count resting (rCEC), activated (aCEC) and progenitor (CEPC) PB AML healthy subjects. In addition we correlated levels with disease status, known prognostic factors response treatment.CEC were quantified by utilizing four-color flow cytometry procedures 48 at time...
In the last decade, peripheral blood was main source of hematopoietic stem cells (HSC) for autologous and allogeneic transplantation. The exact mechanisms HSC mobilization are still not clear efficacy procedure is hardly predictable. Ligand-receptor interactions adhesion molecules, such as SDF1/CXCR4, VLA4/VCAM-1, or CD44/osteopontin, play an important role in homing niche. There some evidence that disruption ligand-receptor complex leads to egress HSCs blood. aim present study evaluation...
Abstract Intensive induction chemotherapy using anthracycline and cytarabine backbone is considered the most effective upfront therapy in physically fit older patients with acute myeloid leukemia (AML). However, outcomes of standard elderly AML are inferior to those observed younger patients, they still unsatisfactory. As addition cladribine known improve outcome patients. The present randomized phase II study compares efficacy toxicity DAC (daunorubicin plus cladribine) regimen DA...
Smac/DIABLO protein promotes caspase-dependent apoptosis by inhibition of inhibitor (IAP) family members. The role in breast cancer has not been yet established. Therefore, the aim study was to assess expression this tumor cells from patients. analyzed 62 patients flow cytometry. obtained results were compared with benign tissue, which served as control (11 fibroadenoma). Expression caspase-3 proteins also evaluated. correlated clinical and pathological data. Although found all examined...
The p73 gene, a member of the p53 family, encodes several variants through differential splicing and use alternative promoters. At NH2 terminus, two different promoters generate full-length DeltaN isoforms, with or without transactivating domain. COOH seven isoforms generated have been cloned. Previous studies demonstrated that DeltaNp73 exert dominant-negative effect on by blocking their transactivation activity hence ability to induce apoptosis. Considerable efforts are made identify...
Bax protein, the proapoptotic member of Bcl-2 protein family, plays key role in apoptosis pathway. THE AIM OF STUDY was to assess expression breast cancer cells.Sixty-two patients were included study. The control group encompassed 11 fibroadenoma patients. Single cells isolated from defrosted samples and prepared for flow cytometry measurement.Median study 7.9% (range: 0-49.4%) significantly lower than (median 15.8%; range 4.9-30.9%; p=0.034). Expression correlated with p53 caspase-3...
The inhibitor of apoptosis protein (IAP) family acts as an pathways. potential prognostic value the expression selected IAP members, XIAP, cIAP-1, cIAP-2 and survivin protein, was evaluated with regard to treatment response survival 56 newly diagnosed adult patients acute myeloid leukemia (AML). presence these members influenced achievement a complete (CR). In addition, overall (OS) by low in univariate multivariate analysis (p = 0.014 p 0.013, respectively). A strong correlation observed...