A5075885630- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Rheumatoid Arthritis Research and Therapies
- Sarcoidosis and Beryllium Toxicity Research
- Inflammatory Myopathies and Dermatomyositis
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Vasculitis and related conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Eosinophilic Disorders and Syndromes
- Mast cells and histamine
- Chronic Lymphocytic Leukemia Research
- Ultrasound in Clinical Applications
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Diabetes and associated disorders
- Urticaria and Related Conditions
- Heat shock proteins research
- thermodynamics and calorimetric analyses
- Dermatological and Skeletal Disorders
Gdańsk Medical University
2016-2025
University of Gdańsk
2018
University Clinical Centre
2012-2018
MRC Human Immunology Unit
2010
John Radcliffe Hospital
2010
Osaka University
2010
Abstract Human CD4+ T lymphocytes undergo aging-related changes leading to decreased immunity infections and neoplasms, increased frequency of autoimmune diseases including rheumatoid arthritis (RA). Certain changes, observed in the cells RA patients, resemble those during physiological aging, but occur at earlier age. Underlying cellular mechanism(s) these similarities are so far largely unknown. Here we show that KLOTHO, a β-glucuronidase gene whose activity associated with aging...
<b>Introduction</b>: Granulomatosis with polyangiitis (GPA) is a rare, ANCA-associated, systemic disease characterized by necrotizing small and medium vessel vasculitis of unknown etiology associated granulomatous inflammation affecting the renal, pulmonary, upper airways, ocular systems other tissues. Histological proof granulomatosis can be obtained biopsy clinically involved sites. The main purpose this study was to examine histopathological changes in non-renal biopsies from...
This study aimed to evaluate changes in plasma amino acid and nicotinamide metabolites concentrations rheumatoid arthritis (RA) a search for potential biomarkers of the disease activity effect treatment. Analysis metabolite patterns with liquid chromatography/mass spectrometry revealed specific RA as well correlations clinical parameters. Combined concentration parameter calculated [aspartic acid] + [threonine] [tryptophan] − [histidine] [phenylalanine] offered strongest correlation (p <...
Objectives Illness perception is a cognitive representation influencing physical and psychological functioning adherence in patients with rheumatic disease. Studies exploring illness systemic lupus erythematosus (SLE) are still scarce none of them have investigated factors determining perception. We aimed to assess identify psychological, clinical sociodemographic that might influence SLE. Methods The study involved 80 SLE (87.5% women, mean age 41.56 years). Brief Perception Questionnaire,...
Background: Cardiac involvement (CI) in systemic sclerosis (SSc) is frequently subclinical and it can be identified up to 80% of autopsied hearts. If present, symptoms are related adverse prognosis, CI represents one the predominant causes SSc-related mortality. Methods: A total 20 patients with a diagnosis SSc were included followed up, 37 volunteers subsequently scanned on 1.5T MR system. Results: Overall, thirteen (65%) had or more abnormal cardiac findings CMR (defined as CI[+]), which...
Summary Rheumatoid arthritis (RA) is a chronic inflammatory disease, with clinical manifestation both systemic and in joints. It has been suggested that age at disease onset and/or patients' have influence on activity outcome. The reasons for the different course of RA older people are not known; however, activation status peripheral blood lymphocytes could be responsible. Our aim was to relate expression markers CD4+ T cells patients measured by DAS28. Seventy were included into...
Abstract Objectives Sjögren's syndrome (SS) is a chronic inflammatory disease with an autoimmune background possible complications from peripheral (PNS) and central nervous system (CNS). The aim of this study was to assess the prevalence describe phenotype neuropathies in patients SS. Materials & Methods We studied fifty primary for involvement. All underwent neurological rheumatological examination followed by nerve conduction studies (NCS) nine nerves. Results Thirty‐six (72%)...
Objective. The mechanism of anti-inflammatory effects methotrexate (MTX) at low dose may relate to a decrease in availability the purine precursor or it depend on accumulation 5-aminoimidazole-4-carboxamide (AICAR) and nucleoside adenosine. aim this study was evaluate possible action by analysis changes blood concentrations pyrimidine metabolites during MTX treatment.
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease which affects approximately 1% of the population worldwide. Recent research on role heat shock proteins (Hsps) in RA development indicates that they may have pro- or anti-inflammatory effect, most probably via modulating cytokine secretion. We investigated type Th1 (INFγ, TNFα, IL-2) and Th2 (IL-10, IL-6, IL-4) levels sera patients healthy controls, using flow cytometric bead array assay, searched for correlations between...
Recent research on the heat shock proteins (Hsps) in chronic inflammatory diseases indicates that Hsps may have disease-suppressive activities. Our aim was to characterize immune response directed bacterial (DnaJ) and human Hsp40s patients with rheumatoid arthritis (RA). We found elevated levels of anti-DnaJ, anti-Hdj2, anti-Hdj3 (but not ant-Hdj1) serum antibodies RA (P < or = 0.001) compared healthy controls. In peripheral blood mononuclear cells (PBMCs) culture, all tested Hsp40...
Objective: The aims of the study were to assess cognitive functions (CF) in patients with mixed connective tissue disease (MCTD) and compare MCTD systemic lupus erythematosus without neuropsychiatric manifestations (NP-SLE non-NP-SLE, respectively) terms CF. Methods: Neuropsychological examination was performed 141 patients: 30 (24 women, 6 men), mean age: 48.07 years, 37 non-NP-SLE (36 1 man), 40.76 years 74 NP-SLE (68 41.97 years. tests structured interview used. Emotional state assessed...
Suicidal ideation is observed in patients with systemic lupus erythematosus (SLE). No study on this notable phenomenon neuropsychiatric SLE (NPSLE) available so far.Participants were 53 consecutive outpatients NPSLE (48 women; mean age 43.8 years) diagnosed according to the American College of Rheumatology nomenclature for syndromes. A Neuropsychiatric Questionnaire (NP-Q) concerning 45 neurological, cognitive and psychiatric symptoms was used assess prevalence self-perceived symptoms. The...
Objective. Amino acids (AA) and their derivatives play an integral role in the synthesis of structural regulatory elements human organisms therefore pathologies such as systemic sclerosis that may alter blood pattern these compounds. This study aimed to evaluate changes plasma concentrations amino acid-related metabolites scleroderma a search for potential biomarkers mechanisms disease. Methods. Plasma samples from 42 patients diagnosed with (SSc) according 2013 American College Rheumatology...
ARTICLE Disease activity in patients with long-lasting rheumatoid arthritis… 591 INTROduCTION Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disease, which not limited to the joints but also associated systemic symptoms of inflammation, including increased erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), shift cytokine balance towards proinflammatory mediators peripheral blood. 1 RA measured by disease score 28 (DAS28) reflects both presence local number...
(1) Background: Impaired nutritional status in systemic sclerosis (SSc) is prevalent. (2) Objective: This study aimed to identify pre-cachexia and malnutrition SSc patients estimate the effectiveness of a high-protein oral supplement (ONS) improving their status. (3) Materials methods: The population comprised 56 control group 49 healthy persons. After baseline clinical evaluation, bioelectrical impedance analysis (BIA), laboratory tests, were divided into well-nourished, pre-cachectic,...