A5100718306- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Sinusitis and nasal conditions
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neurosurgical Procedures and Complications
- Nasal Surgery and Airway Studies
- Liver physiology and pathology
- Diverse Approaches in Healthcare and Education Studies
- Radiomics and Machine Learning in Medical Imaging
- Organ Transplantation Techniques and Outcomes
- Autophagy in Disease and Therapy
- CNS Lymphoma Diagnosis and Treatment
- Spinal Hematomas and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Anesthesia and Pain Management
- Education and Learning Interventions
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
Seoul St. Mary's Hospital
2016-2025
Catholic University of Korea
2016-2025
St. Vincent's Hospital
2024
Sahmyook University
2024
National Quarantine Station
2022-2023
Korea Disease Control and Prevention Agency
2022-2023
Samsung Medical Center
2021-2022
Sungkyunkwan University
2021-2022
Konkuk University
2016-2017
The Neurological Institute
2014
Abstract Background Although meningioma is the most common primary brain tumor, treatments rely on surgery and radiotherapy, recurrent meningiomas have no standard therapeutic options due to a lack of clinically relevant research models. Current cell lines or organoids cannot reflect biological features patient tumors since they undergo transformation along culture consist only tumor cells without microenvironment. We aim establish patient-derived (MNOs) preserving diverse types...
Abstract Bioartificial liver (BAL) devices have been developed to treat patients undergoing acute failure. One of the most important parameters consider in designing these is oxygen consumption rate seeded hepatocytes which are known rates 10 times higher than other cell types. Hepatocytes various culture configurations tested BAL including those formats that involve co‐culture with In this study, we investigated, for first time, uptake (OUR)s co‐cultured 3T3‐J2 fibroblasts at hepatocyte...
Abstract Bioartificial liver (BAL) devices with fully functioning hepatocytes have the potential to provide temporary hepatic support for patients failure. The goal of this study was optimize flow environment cultured in a stacked substrate, radial bioreactor. Photolithographic techniques were used microfabricate concentric grooves onto underlying glass substrates. microgrooves served protect seeded from high shear stresses caused by volumetric rates necessary adequate convective oxygen...
One of the major hurdles cellular therapies for treatment liver failure is low availability functional human hepatocytes. While embryonic stem (ES) cells represent a potential cell source therapy, current methods differentiation result in mixed populations or yields interest. Here we describe rapid, direct method that homogeneous population endoderm-like with 95% purity. Mouse ES cultured on top collagen-sandwiched hepatocytes differentiated and proliferated into uniform cells. The was...
Glioma is caused by multiple genomic alterations. The evolving classification of gliomas emphasizes the significance molecular testing. Next generation sequencing (NGS) offers assessment parallel combinations genetic alterations and identifying actionable mutations that guide treatment. This study comprehensively analyzed glioma patients using multi-gene NGS panels, providing powerful insights to inform diagnostic targeted therapies.
Objective: This study introduces a novel, minimally invasive approach to the infratemporal fossa (ITF) using Hartel's method for trigeminal neuralgia. Unlike traditional open approaches ITF, our technique employs transoral endoscopic method. We incorporate stepwise cadaveric dissection enhance understanding of this innovative technique.
The present study was conducted to examine the reliability and validity of a Phlegm Pattern Questionnaire (PPQ) that developed within context Traditional Chinese Medicine.A total 292 normal subjects 61 inpatients were asked complete PPQ. Among subjects, 73 college students additionally Profile Mood States (POMS) Chalder Fatigue Scale (CFS). Three (3) clinicians determined whether exhibited (PP). authors estimated internal consistency construct for PPQ using data from inpatient subjects. POMS...
Background There have been no guidelines for the management of adult patients with diffuse midline glioma (DMG), H3K27M-mutant in Korea since 2016 revised WHO classification newly defined this disease entity.Thus, Korean Society Neuro-Oncology (KSNO), a multidisciplinary academic society, had begun preparing DMG 2019. MethodsThe Working Group was composed 27 medical experts Korea.References were identified through searches PubMed, MEDLINE, EMBASE, and Cochrane CEN-TRAL using specific...
Endoscopic sinus and skull base surgeries are minimally invasive surgical techniques that reduce postoperative symptoms complications enhance patients' quality of life. However, to ensure excellent outcomes after such interventions, intimate familiarity with important landmarks high-level endoscope manipulation skills essential. Cadaver training is one possible option, but cadavers expensive, scarce, nonreusable cadaver work requires specialized equipment staff. In addition, it difficult...
Chronic subdural hematoma (CSDH) patients using antithrombotic agents (AT) at high risk for cardiovascular disease are increasing. The authors aimed to analyze the factors influencing outcome by targeting AT and establish a desirable treatment strategy.A retrospective analysis was performed on data from 462 who underwent burr hole trephination (BHT) surgery CSDH five hospitals March 2010 June 2021. Outcomes included incidence of postoperative acute bleeding, recurrence rate, morbidity or...
Objective: This paper proposes a virtual reality (VR) haptic simulator with realistic instruments, an exchangeable patient-specific three-dimensional (3D)–printed external nostril and caudal septum model to facilitate real surgical motion for training in endoscopic sinus skull–base surgery. Study design Setting: industry-academy cooperation development Methods: The VR consists of the main body, monitor, endoscope device, 2 devices, holder support fixture, pair pedals. location device is...
The impact of obesity on survival outcomes in patients with glioblastoma (GBM) has not been well reported and the results for are currently unclear. We investigated effect newly diagnosed GBM.Using electronic medical records, all GBM that visited Seoul St. Mary's Hospital between 2008 2018 were reviewed. A total 177 met our eligibility criteria. cut-off point BMI was 23.0 kg/m2 based previous studies which focused Asian populations.A overall median 24.5 (range 15.82-39.26). About 62 who had...
We describe the strategy used to repair intraoperative leaks of various grades and define factors for preventing postoperative cerebrospinal fluid leakage (CSF) after surgery via endoscopic endonasal transsphenoidal approach (EETA).Retrospective chart review at a tertiary referral center.Patients who underwent EETA from January 2009 May 2020 were retrospectively reviewed. Intraoperative CSF was graded 0-3 in terms dural defect size; repairs depending on grade.A total 777 patients 869...
Objective: In February 2009, the authors’ center formed a team of neurosurgeons, otolaryngologists, endocrinologists, and radiologists to perform pituitary surgery using endoscopic endonasal transsphenoidal approach (EETSA). This paper reviews experience with technique, pathological outcomes, hormone profiles, postoperative complications. Methods: Between 2009 December 2015, 535 patients underwent EETSA 2-nostrils/4-hands surgery. All had preoperative neurophthalmological endocrinological...
Immune responses for cancer cells can be altered according to genetic variation of human leukocyte antigen (HLA). Association HLA polymorphism with risk various types is well known. However, the association between and glioblastoma (GBM) remains uncertain. We sought evaluate GBM development in Koreans.A case-control study was performed identify odds ratios (OR) class I II genes GBM. The control group consisted 142 healthy Korean volunteers, 80 patients newly diagnosed at our institution....