A5051258968- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Glycation End Products research
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Diet and metabolism studies
- Heart Rate Variability and Autonomic Control
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Risk Factors
- Sodium Intake and Health
- Alcohol Consumption and Health Effects
- Fatty Acid Research and Health
- Hormonal Regulation and Hypertension
- Folate and B Vitamins Research
- Obesity, Physical Activity, Diet
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Cancer, Lipids, and Metabolism
- Acute Ischemic Stroke Management
- Growth Hormone and Insulin-like Growth Factors
Kurume University
2015-2024
Taisho Pharmaceutical (Japan)
2024
National Center for Global Health and Medicine
2023
Creative Commons
2016
Icahn School of Medicine at Mount Sinai
2016
Kanazawa Medical University
2014
University of Minnesota
2011
The University of Tokyo
1998-2006
Cardiovascular Institute Hospital
2005-2006
Shizuoka Institute of Science and Technology
2006
Pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis with neuronal differentiating activity, inhibits endothelial cell injury in vitro, thus suggesting the involvement PEDF atherosclerosis. Therefore, elucidating relationship between serum levels and coronary risk factors could provide clue to understanding pathophysiological role vivo.We examined whether were associated for artery disease.The study was designed as cross-sectional study.The set within general...
Abstract Background Advanced glycation end products (AGEs)‐receptor (RAGE) axis is implicated in diabetic vascular complication. Since a soluble form of RAGE (sRAGE) could be generated from the cleavage cell surface endothelial cells (ECs), serum sRAGE levels may elevated diabetes consequent to EC damage. In this study, we examined whether were type 2 patients compared with non‐diabetic healthy subjects. Methods Serum 75 Japanese (29 men and 46 women; mean age 66 ± 11 years) age‐ sex‐matched...
Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in accelerated atherosclerosis diabetes. We have recently found that the soluble form of RAGE (sRAGE) levels are significantly higher type 2 diabetic patients than nondiabetic subjects positively associated with presence coronary artery disease In this study, we examined whether serum sRAGE correlated inflammatory biomarkers Eighty-six Japanese (36 men 50 women, mean age 68.4 ± 9.6 years) underwent a...
High-density lipoprotein cholesterol (HDL-C) and low-density (LDL-C) are strong predictors of atherosclerosis. Statin-induced changes in the ratio LDL-C to HDL-C (LDL-C/HDL-C) predicted atherosclerosis progression better than or alone. However, best predictor subclinical remains unknown. Our objective was investigate this issue by measuring carotid intima-media thickness (IMT). A total 1,920 subjects received health examinations 1999, were followed up 2007. Changes IMT (follow-up...
Ezetimibe ameliorates serum low-density lipoprotein cholesterol (LDL-c) and it has been approved for the treatment of hypercholesterolemia. However, effects ezetimibe on specific biomarkers have not fully clarified in obese Japanese patients. A total 101 patients (47 males 54 females) were registered this study during 2011 2012. All over 20 years old, [body mass index (BMI) ≥ 25kg/m2] had hypercholesterolemia (LDL-c 120mg/dl). After excluding 10 subjects (7 who dropped out 3 with missing...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStructure of Apoptolidin, a Specific Apoptosis Inducer in Transformed CellsYoichi Hayakawa, Jin Woo Kim, Hisashi Adachi, Kazuo Shin-ya, Ken-ichi Fujita, and Haruo SetoView Author Information Institute Molecular Cellular Biosciences The University Tokyo, Bunkyo-ku, Tokyo 113, Japan JEOL Datum Ltd., 3-15-5, Nish-shinjuku Shinjuku-ku, 163, Cite this: J. Am. Chem. Soc. 1998, 120, 14, 3524–3525Publication Date (Web):March 26, 1998Publication...
C-reactive protein (CRP) was recently identified as a prognostic factor for patients with hepatocellular carcinoma (HCC) after surgical resection. We investigated the relationship between serum levels of high sensitivity CRP (H-CRP) and prognosis HCC patients.We conducted cohort study 90 enrolled from 1997 to 1998. All were treated followed mean period 3.2 years. Clinical variables compared positive H-CRP (serum >/=3.0 mg/L, n=47) those negative <3.0 n=43). also determined in patients.The...
Atherosclerosis is an inflammatory disease. Monocyte chemoattractant protein-1 (MCP-1) essential chemokine responsible for the recruitment of monocytes to lesions in vasculature, initial step atherosclerosis. Since serum levels MCP-1 are higher patients with type 2 diabetes, inhibition may be a novel therapeutic target prevention accelerated atherosclerosis diabetes. However, little known about regulation and determinants In this study, we examined diabetic patients.Eighty-six consecutive...
Abstract Background There is little data on the association between lower nutrition represented by serum albumin levels and related factors in a general population. The present study aimed to determine whether level positioned as some kind of biomarker with frailty measures, trace elements, an inflammation marker. Methods In 2018, we performed epidemiological survey 1368 subjects who resided Tanushimaru, Japan, which examined blood chemistry including albumin, hormone levels, carotid...
We examined whether hyperhomocysteinemia is an independent risk factor for increased carotid artery intimal-medial wall thickness (IMT) in a large, randomly selected community Japan where the dietary habit different and incidence of coronary disease lower compared with those western countries.In 1111 cases (452 men, 659 women) aged 63+/-10 years old (range, 40 to 94 years) recruited from population-based survey performed 1999, we measured fasting plasma total homocysteine levels bilateral...
Abstract Background Pigment epithelium‐derived factor (PEDF) inhibits endothelial cell injury. Further, serum levels of PEDF are elevated in the metabolic syndrome. These observations suggest that may be as a counter‐system against vascular damage However, little is known about regulation patients with diabetes. In order to clarify determinants PEDF, here, we examined relationship between 1‐year changes and those anthropometric variables type 2 diabetic patients. Methods Eighty‐six...
Aldosterone plays a role in hypertension, and hypertension is prevalent patients with insulin resistance. Cross-sectional studies have reported that plasma aldosterone levels are higher However, it not known whether predict the development of Subjects present study were 1235 local residents (490 men 745 women) who participated health screenings Japan 1999. Plasma measured by radioimmunoassay. We investigated cross-sectional relationship between resistance (homeostasis model assessment index...
Although chronic subdural hematoma (CSDH) is one of the most common entities encountered in neurosurgical practice, optimal surgical treatment for CSDH remains controversial. This study retrospectively compared results between burr hole drainage alone and with irrigation. Ninety-two patients underwent surgery at our institution from January 1998 through December 2009. Fifty-eight received (Group A), while 34 were treated using irrigation B). Outcomes, recurrence rates, death rates two groups...