A5021449136- Phytochemicals and Antioxidant Activities
- Phytoestrogen effects and research
- Tea Polyphenols and Effects
- Antioxidant Activity and Oxidative Stress
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Consumer Attitudes and Food Labeling
- Natural Antidiabetic Agents Studies
- Ginkgo biloba and Cashew Applications
- Biochemical Analysis and Sensing Techniques
- Metabolomics and Mass Spectrometry Studies
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Free Radicals and Antioxidants
- Adipose Tissue and Metabolism
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Inflammatory mediators and NSAID effects
- Antiplatelet Therapy and Cardiovascular Diseases
- Vitamin K Research Studies
- Phytase and its Applications
- Microbial Metabolites in Food Biotechnology
- Atherosclerosis and Cardiovascular Diseases
American Geriatrics Society
2021
Wageningen University & Research
2010-2019
TiFN
2009-2018
Food & Nutrition
2015
Unilever (Netherlands)
2015
California Polytechnic State University
2015
Cambridge University Press
2015
New York University Press
2015
National Institute for Public Health and the Environment
2000-2006
University of Helsinki
2004
To determine whether flavonoid intake explains differences in mortality rates from chronic diseases between populations.Cross-cultural correlation study.Sixteen cohorts of the Seven Countries Study whom at baseline around 1960 was estimated by analysis equivalent food composites that represented average diet cohorts.Mortality coronary heart disease, cancer (various sites), and all causes 16 after 25 years follow-up.Average antioxidant flavonoids inversely associated with disease explained...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContent of potentially anticarcinogenic flavonoids 28 vegetables and 9 fruits commonly consumed in the NetherlandsMichael G. L. Hertog, Peter C. H. Hollman, Martijn B. KatanCite this: J. Agric. Food Chem. 1992, 40, 12, 2379–2383Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/jf00024a011https://doi.org/10.1021/jf00024a011research-articleACS...
Abstract Flavonoids are strong antioxidants that occur naturally in foods and can inhibit carcinogenesis rodents. Accurate data on population‐wide intakes of flavonoids not available. Here, using the Dutch National Food Consumption Survey 1987–1988, we report intake potentially anticarcinogenic quercetin, kaempferol, myricetin, apigenin, luteolin among 4,112 adults. The flavonoid content vegetables, fruits, beverages was determined by high‐performance liquid chromatography. In all subjects,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContent of potentially anticarcinogenic flavonoids tea infusions, wines, and fruit juicesMichael G. L. Hertog, Peter C. H. Hollman, Betty. van de PutteCite this: J. Agric. Food Chem. 1993, 41, 8, 1242–1246Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/jf00032a015https://doi.org/10.1021/jf00032a015research-articleACS PublicationsRequest reuse...
Quercetin is a strong antioxidant and major dietary flavonoid. Epidemiological studies suggest that consumption of quercetin protects against cardiovascular disease, but its absorption in man controversial. We fed nine subjects single large dose onions, which contain glucose conjugates quercetin, apples, both non‐glucose glycosides, or pure quercetin‐3‐rutinoside, the glycoside tea. Plasma levels were then measured over 36 h. Bioavailability from apples rutinoside was 30% relative to onions....
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOptimization of a quantitative HPLC determination potentially anticarcinogenic flavonoids in vegetables and fruitsMichael G. L. Hertog, Peter C. H. Hollman, Dini P. VenemaCite this: J. Agric. Food Chem. 1992, 40, 9, 1591–1598Publication Date (Print):September 1, 1992Publication History Published online1 May 2002Published inissue 1 September 1992https://pubs.acs.org/doi/10.1021/jf00021a023https://doi.org/10.1021/jf00021a023research-articleACS...
We report the results of a 28-day oral exposure study in rats, exposed to <20 nm noncoated, or <15 PVP-coated silver nanoparticles ([Ag] = 90 mg/kg body weight (bw)), AgNO(3) 9 bw), carrier solution only. Dissection was performed at day 29, and after wash-out period 1 8 weeks. Silver present all examined organs with highest levels liver spleen for treatments. concentrations were highly correlated amount Ag(+) nanoparticle suspension, indicating that mainly Ag(+), much lesser extent...
Flavonoids are antioxidants present in plant foods. They occur mainly as glycosides, i.e. linked with various sugars. It is uncertain to what extent dietary flavonoid glycosides absorbed from the gut. We investigated how nature of sugar group affected absorption one major flavonoid, quercetin. Quercetin glucose, quercetin glucoside and rutinose, rutinoside, both widely When we fed these compounds nine volunteers, peak concentration (Cmax) plasma was 20 times higher reached (Tmax) more than...
Total flavonol and flavone contents of foods have been determined with validated state-of-the-art methods. Quercetin dominates, levels found in vegetables fruits are below 10 mg kg−1. However, high concentrations onions (300 kg−1), kale (450 broccoli (100 beans (50 apples blackcurrants (40 tea (30 l−1). The dietary intake flavonols varies 10-fold between countries (6–60 day−1). Flavones minor importance the diet. Tea, wine most important sources flavanols, but there gaps our knowledge on...
Enterolignans (enterodiol and enterolactone) can potentially reduce the risk of certain cancers cardiovascular diseases. are formed by intestinal microflora after consumption plant lignans. Until recently, only secoisolariciresinol matairesinol were considered enterolignan precursors, but now several new precursors have been identified, which lariciresinol pinoresinol a high degree conversion. Quantitative data on contents in foods these not available. Thus, aim this study was to compile...
Catechins, compounds that belong to the flavonoid class, are potentially beneficial human health. To enable epidemiological evaluation of these compounds, data on their contents in foods required. HPLC with UV and fluorescence detection was used determine levels (+)-catechin, (-)-epicatechin, (+)-gallocatechin (GC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECg), (EGCg) 24 types fruits, 27 vegetables legumes, some staple foods, processed commonly consumed The Netherlands. Most...
Procyanidins (PCs) are highly abundant phenolic compounds in the human diet and might be responsible for health effects of chocolate wine. Due to low absorption intact PCs, microbial metabolism play an important role. So far, only a few studies, with crude extracts rich PCs but also containing multitude other compounds, have been performed reveal PC metabolites. Therefore, origin metabolites remains questionable. This study included vitro fermentation purified dimers microbiota. The main...
Abstract Plant phenols are mostly products of the phenylpropanoid pathway and comprise a large variety compounds: cinnamic acids, benzoic flavonoids, proanthocyanidins, stilbenes, coumarins, lignans lignins. They strong antioxidants might prevent oxidative damage to biomolecules such as DNA, lipids proteins which play role in chronic diseases cancer cardiovascular disease. may interfere with all stages process, potentially resulting reduction risk. Only flavonols have been investigated...