A5029443992- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Carbon Nanotubes in Composites
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Advanced Sensor and Energy Harvesting Materials
- Ferroptosis and cancer prognosis
- Oral and gingival health research
- IgG4-Related and Inflammatory Diseases
- Urologic and reproductive health conditions
- Breast Lesions and Carcinomas
- Soft tissue tumor case studies
- Lipid metabolism and biosynthesis
Yonsei University
2016-2025
Severance Hospital
2016-2024
Korea Institute of Science and Technology
2022
Research Institute of Radio
2019
Ajou University
2019
Hesco (United States)
2019
Hanyang University
1997
// Ji-Ye Kim 1, 2 , Hyang Sook Jeong Taek Chung Moonsik Ji Hee Lee Woo Jung and Ja Seung Koo 1 Department of Pathology Translational Genomics, Sungkyunkwan University School Medicine, Samsung Medical Center, Seoul, Republic Korea Pathology, Yonsei College Severance Hospital, Correspondence to: Koo, email: kjs1976@yuhs.ac Keywords: PHH3, invasive breast cancer, proliferation, reproducibility, prognostic value Received: February 26, 2016 Accepted: April 25,...
Background and Aims: Primary liver cancers (LCs), including HCC intrahepatic cholangiocarcinoma (iCCA), are derived from a common developmental lineage, conferring molecular spectrum between them. To elucidate the spectrum, we performed an integrative analysis of transcriptome profiles associated with patients’ radiopathologic features. Approach Results: We identified four LC subtypes (LC1–LC4) RNA‐sequencing profiles, revealing intermediate iCCA. LC1 is typical characterized by active bile...
Recently, anti-programmed cell death-1/anti-programmed death ligand-1 (anti-PD1/L1) immunotherapy has been demonstrated for its efficacy when combined with cytotoxic chemotherapy in randomized phase 3 trials advanced biliary tract cancer (BTC). However, no biomarker predictive of benefit established anti-PD1/L1 BTC. Here, we evaluated tumor-infiltrating lymphocytes (TIL) using artificial intelligence-powered immune phenotype (AI-IP) analysis BTC treated anti-PD1.
Abstract Background & Aims Intrahepatic cholangiocarcinoma ( iCCA ) is a heterogeneous entity with diverse aetiologies, morphologies and clinical outcomes. Recently, histopathological distinction of cholangiolocellular differentiation CD has been suggested. However, its genome‐wide molecular features significance remain unclear. Methods Based on status, we stratified s into (n=20) without (n=102), performed an integrative analysis using transcriptomic clinicopathological profiles....
629 Background: HER2 overexpression and amplification have been identified as a promising druggable target in biliary tract cancer (BTC). This study aims to characterize the clinical molecular outcomes associated with positivity BTC evaluate prognostic implications of HER2-targeted therapies. Methods: A retrospective was conducted involving patients advanced diagnosed at Yonsei Cancer Center (YCC) University Texas MD Anderson (MDACC) between 2009 2023. Patients were classified HER2-positive...
Intrahepatic cholangiocarcinoma (iCCA) with a ductal plate malformation (DPM) pattern is recently recognized rare variant. The genomic profile of iCCA DPM needs to be elucidated.Cases were retrospectively reviewed based on the medical records, pathology slides, and magnetic resonance imaging (MRI) reports collected between 2010 2019 at single center. Massive parallel sequencing was performed for >500 cancer-related genes.From total 175 iCCAs, five (2.9%) cases identified. All small duct...
Background/Aims: Lysyl oxidase-like 2 (LOXL2), a collagenmodifying enzyme, has been implicated in cancer invasiveness and metastasis.Methods: We evaluated the expression of LOXL2 protein, addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, interleukin 6, 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry. Results: positivity was found 14.3% (15/105) HCCs, it significantly associated with high serum α-fetoprotein levels, poor...
Gastric-type mucinous carcinoma (MC-G) of the uterine cervix displays distinct morphological features and an aggressive clinical course. The expression status p16 in stroma has not been investigated adenocarcinoma cervix. Stromal was evaluated endocervical adenocarcinomas, including usual-type (UEA), intestinal-type (MC-I), MC-G. Whether stromal varied significantly according to histological subtype whether is associated with clinicopathological characteristics MC-G also...
Abstract The expression of estrogen receptor alpha (ERα, encoded by ESR1 ) has been shown to be associated with the prognostic outcomes patients in various cancers; however, its and mechanistic significance hepatocellular carcinoma (HCC) remain unclear. Here, we evaluated ERα association clinicopathological features 339 HCC patients. was expressed 9.4% (32/339) HCCs related better overall survival (OS; hazard ratio [HR] = 0.11, p 0.009, 95% C.I. 0.016–0.82) disease-free (DFS, HR 0.4, 0.013,...
Comparable to circumferential resection margin in rectal cancer, radial is a potential prognostic factor colon cancer that has just begun be studied. No previous studies have investigated the influence of context complete mesocolic excision.This study aimed examine impact on oncologic outcomes after excision for cancer.We retrospectively reviewed patients with stage I III who underwent curative from October 2010 March 2013.This was conducted using prospective colorectal registry Severance...
Intermediate cell carcinoma (Int-CA) is a rare and enigmatic primary liver cancer characterized by uniform tumor cells exhibiting mixed features of both HCC intrahepatic cholangiocarcinoma. Despite the unique pathological int-CA, its molecular characteristics remain unclear yet.
We aimed to investigate multimodality imaging findings of intraductal tubulopapillary neoplasms (ITPN) the pancreas.This study was approved by institutional review board with waived informed consent. A total eight patients were histopathologically diagnosed pancreatic ITPN in a single institution over 6-year period. The dynamic contrast-enhanced computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP), endoscopic ultrasonography (EUS), and positron emission...
Accurate classification of well-differentiated hepatocellular neoplasms can be challenging especially in core biopsies. Prostate-specific membrane antigen (PSMA) has been shown to highlight tumor-associated neovasculature many nonprostatic solid tumors including carcinoma (HCC). Archived 164 hepatectomies and explants with 68 HCCs, 31 adenoma (HA), 24 dysplastic nodules (DN), 42 metastases were retrieved, pathologic parameters evaluated. Sensitivity, specificity, accuracy, positive, negative...
We developed a batch-processed, flexible tactile sensor using carbon nanotube (CNT)-polymer composites. The fabricated consists of substrate (polyimide), four sensing parts (CNT-polymer composites) and bump structure (SU-8). CNT-polymer composite was patterned on polyimide through large area screen printing process. proposed has advantages in high sensitivity, mechanical flexibility facile fabrication It showed outstanding piezoresistive characteristics the pressure range up to 2 N.
We have developed a novel three dimensional tactile sensor based on vertically aligned carbon nanotubes. The nanotubes were directly synthesized silicon microstructures and these CNTs-on-microstructures integrated to flexible polydimethylsiloxane layers. Each has four sensing parts the direction of force can be detected by monitoring increase or decrease electrical resistance in each part. High gauge factor up 272 fast response less than 10 ms been experimentally verified from presented...
The methylated SEPT9 DNA ( mSEPT9 ) in plasma is a US Food and Drug Administration (FDA)-approved screening biomarker colorectal cancer emerging as promising diagnostic prognostic hepatocellular carcinoma (HCC). We evaluated the protein expression by immunohistochemistry (IHC) various hepatic tumors from 164 hepatectomies explants. Cases diagnosed HCC (n=68), adenoma (n=31), dysplastic nodule (n=24), metastasis (n=41) were retrieved. stain was performed on representative tissue blocks...
Indeterminate dendritic cell tumor (IDCT) is a that displays histologic features similar to those of Langerhans cells. The origin the indeterminate cells may represent precursors or skin IDCT extremely rare, and progression predictive factors are not well known. Here, we report case 61-year-old man who presented with papule on his back was finally diagnosed based histology immunohistochemistry. recurred three months after surgical excision.