A5064900627- Salivary Gland Tumors Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Chromatin Remodeling and Cancer
- Cancer Immunotherapy and Biomarkers
- Ovarian cancer diagnosis and treatment
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- Protein Tyrosine Phosphatases
- Endometrial and Cervical Cancer Treatments
- Tracheal and airway disorders
- Lymphoma Diagnosis and Treatment
- Ear and Head Tumors
- Viral-associated cancers and disorders
- Lipoproteins and Cardiovascular Health
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer therapeutics and mechanisms
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- Cancer and Skin Lesions
- 14-3-3 protein interactions
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- Uterine Myomas and Treatments
Sungkyunkwan University
2006-2024
Samsung Medical Center
2006-2024
CrystalGenomics (South Korea)
2024
Chung-Ang University Hospital
2015
The purpose of this randomised phase III trial was to evaluate whether the addition simvastatin, a synthetic 3-hydroxy-3methyglutaryl coenzyme A reductase inhibitor, XELIRI/FOLFIRI chemotherapy regimens confers clinical benefit patients with previously treated metastatic colorectal cancer. We undertook double-blind, placebo-controlled 269 for cancer and enrolled in 5 centres South Korea. Patients were randomly assigned (1 : 1) one following groups: FOLFIRI/XELIRI plus simvastatin (40 mg) or...
Nuclear protein in testis (NUT) carcinoma is a rare tumor associated with NUT rearrangement that can present as poorly differentiated to undifferentiated carcinoma, or without abrupt squamous differentiation. It often misdiagnosed if not suspected. In this study, we retrospectively analyzed pulmonary cases diagnosed immunohistochemical staining and discuss the differential diagnosis provide information for aggressive entity.Cases, "NUT carcinoma" lung pleura "metastatic from lung" lymph...
Background: Recurrence in pleomorphic adenoma (PA) has been debated as a risk factor for malignant transformation (MT). In this study, we investigated whether recurrence is MT, by longitudinally analyzing cases with recurrent PA (RPA), and carcinomas from (CXPA) or RPA (CXRPA). Methods: The study population included 24 CXPA, RPA, 6 CXRPA, 386 (study period 2010–2018). Time event data were collected the medical documents to identify time–event sequences. Results: time interval MT CXRPA was...
Neural stem cells (NSCs) in the adult hippocampus divide infrequently; endogenous molecules modulating hippocampal neurogenesis (AHN) remain largely unknown.Here, we show that ErbB3 binding protein 1 (Ebp1), which plays important roles embryonic neurodevelopment, acts as an essential modulator of neurogenic factors.In vivo analysis Ebp1 neuron depletion mice showed impaired AHN with a low number NSCs and neuroblasts.Ebp1 leads to transcriptional repression Bmp4 suppression Ascl1 promoter...
The ARID1A gene is pivotal in chromatin remodeling and genomic integrity frequently mutated various cancer types. mutation the second most tumor suppressor has been suggested as a predictor of immunotherapeutic responsiveness gastric carcinoma (GC). Despite its significance, relationship among somatic mutations, RNA expression levels, protein remains unclear, particularly GC. For this purpose, we performed comparative study two cohorts. Cohort 1 used next-generation sequencing (NGS) to...
Irinotecan and cisplatin demonstrated promising outcomes in extensive-stage small-cell lung cancer. According to the dosage schedule of irinotecan, efficacy toxicity profiles showed subtle differences. This study was designed evaluate 3-week irinotecan/cisplatin patients with previously untreated The primary objective response rate secondary objectives were overall survival progression-free survival. Patients cancer enrolled. 65 mg m-2 administered on days 1 8 60 day 1. Treatment repeated...
Metastatic leiomyosarcoma to the thyroid is an extremely rare occurrence, and only 18 cases have been reported. Here, we report a case of 37-year-old woman who presented with multiple masses on scalp. Excisional biopsy was done mass revealed fascicles smooth muscle fibers which showed positive staining for actin, thus confirming diagnosis leiomyosarcoma. The patient also found 0.9 cm within left thyroid. Fine-needle aspiration cytological smear hypercellular spindle cell clusters...
Abstract Single-cell RNA transcriptomics has revealed the intricate heterogeneity of both tumors and their microenvironment. However, a notable limitation is its inability to retain spatial context, crucial aspect understanding cell identity function. In this study, we employed imaging-based single-cell elucidate tumor immunological landscapes two breast cancer samples. By resolving over 400 000 cells per slide, demonstrated that transcriptional differences lead structural disparities within...
The incidence of BRAF V600E mutation in non-small cell lung carcinoma (NSCLC) is lower than 2%, which poses difficulties finding legitimate patients for targeted therapy. We investigated the predictive factors pertaining to and effectiveness VE1 antibody as a screening method patient selection.The study was designed into two steps. In first group, BRAF-mutated NSCLCs were identified from sequencing data determine features mutation. results group helped collection adenocarcinomas with...
<title>Abstract</title> The tumor microenvironment (TME) consists of tumor-associated stroma and infiltrating lymphocytes (TIL). Assessment tumor-stroma ratio (TSR) TIL in the histopathological specimens can provide important prognostic information various diverse solid tumors including gastric cancer (GC). However, implementation as a routine clinical biomarker has not been developed. In 320 GC patients, Generative Adversarial Network (GAN)-based virtual cytokeratin leukocyte common antigen...
Apocrine differentiation and androgen receptor (AR) positivity represent a specific subset of triple-negative breast cancer (TNBC) are often considered potential prognostic or predictive factors.
It remains uncertain how long pure ground-glass nodules (pGGNs) detected on low-dose CT (LDCT) imaging should be followed up. Further studies with longer follow-up periods are needed to determine the optimal duration for pGGNs.
Despite atezolizumab plus bevacizumab being a standard treatment for advanced hepatocellular carcinoma (HCC), significant proportion of patients do not achieve durable benefit. This study aimed to identify predictive biomarkers this therapy by investigating the role immune activation within tumor microenvironment (TME). We characterized intratumoral TME with HCC treated using single cell transcriptomics on pretreatment biopsies from 12 patients. To complement and support these findings, we...
Misdiagnosis of endocervical adenocarcinoma (EAC) as endometrial endometrioid carcinoma (EEC) is one the major concerns when evaluating curettage specimens. It difficult to differentiate EAC involving endometrium from EEC, particularly specimens have only a few small tumor fragments. We report case <i>in situ</i> (AIS) with multifocal microscopic involvement endometrium. The specimen obtained an 82-year-old woman consisted large volume blood and fibrin, tissue fragments showing...
Crohn’s disease (CD) is a type of inflammatory bowel (IBD) characterized by chronic granulomatous inflammation any part the body, primarily gastrointestinal (GI) tract, and increasing in incidence worldwide. As CD systemic disease, features typically manifest GI tract; however, variety extra-intestinal manifestations, such as involvement joints, skin, eyes may also occur. Although pyogenic liver abscess itself rare general population (approximately 3–5 per 100,000 hospital admissions), it an...